Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Small-Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System

(2014) Dennis L. Buckley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Dual Small-Molecule Rheostat for Precise Control of Protein Concentration in Mammalian Cells

(2014) Yu Hsuan Lin et al.   CHEMBIOCHEM

A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins

(2013) Taavi K. Neklesa et al.   ACS Chemical Biology

Castration-resistant prostate cancer: Adaptive responses in the androgen axis

(2013) Alison Egan et al.   CANCER TREATMENT REVIEWS

An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)

(2013) M. Korpal et al.   Cancer Discovery

Overcoming mutation-based resistance to antiandrogens with rational drug design

(2013) Minna D Balbas et al.   eLife

Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

(2012) Hyun Seop Tae et al.   CHEMBIOCHEM

Inhibitor Mediated Protein Degradation

(2012) Marcus J.C. Long et al.   CHEMISTRY & BIOLOGY

Fulvestrant

(2011) Jamie D. Croxtall et al.   DRUGS

Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

(2011) Taavi K Neklesa et al.   Nature Chemical Biology

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Targeting the Undruggable Proteome: The Small Molecules of My Dreams

(2010) Craig M. Crews   CHEMISTRY & BIOLOGY

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One

(2008) Timothy W. Corson et al.   ACS Chemical Biology

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

(2008) Ashley R. Schneekloth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven

(2008) Gerhardt Attard et al.   JOURNAL OF CLINICAL ONCOLOGY

Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol

(2008) Paulette R. Dillard et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY