Selectively Targeting the DNA-binding Domain of the Androgen Receptor as a Prospective Therapy for Prostate Cancer

Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor

(2014) Huifang Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Independent and Tissue-Selective Androgen Receptor Inhibition by Pyrvinium

(2013) Minyoung Lim et al.   ACS Chemical Biology

Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer

(2013) Dana Rathkopf et al.   CANCER JOURNAL

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

(2013) Nada Lallous et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Novel Androgen Receptor Antagonists Using Structure- and Ligand-Based Methods

(2013) Huifang Li et al.   Journal of Chemical Information and Modeling

Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole Derivatives

(2013) Ravi Shashi Nayana Munuganti et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth In Vitro and In Vivo

(2013) H. Kuruma et al.   MOLECULAR CANCER THERAPEUTICS

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer

(2013) M. D. Nyquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment options in castration-resistant prostate cancer: Current therapies and emerging docetaxel-based regimens

(2013) Fred Saad et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Interplay Between Genomic Alterations and Androgen Receptor Signaling During Prostate Cancer Development and Progression

(2013) Michael D. Nyquist et al.   Hormones & Cancer

Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer

(2012) R. Ferraldeschi et al.   Annual Review of Medicine

Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines

(2012) Y. Li et al.   CANCER RESEARCH

Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

(2012) Siu Chiu Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stepwise androgen receptor dimerization

(2012) M. E. van Royen et al.   JOURNAL OF CELL SCIENCE

Beyond the Ligand-Binding Pocket: Targeting Alternate Sites in Nuclear Receptors

(2012) Laura Caboni et al.   MEDICINAL RESEARCH REVIEWS

Androgen action and metabolism in prostate cancer

(2012) Sean M. Green et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Unexpected Binding Orientation of Bulky-B-Ring Anti-Androgens and Implications for Future Drug Targets

(2011) Charles B. Duke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

(2011) Nathan A. Lack et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

(2010) Raymond J. Andersen et al.   CANCER CELL

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

(2010) Shihua Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

(2010) P. A. Watson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells

(2009) K-x Zhang et al.   CANCER GENE THERAPY

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth

(2009) Z. Guo et al.   CANCER RESEARCH

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGICAL SCIENCES

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

(2008) S. M. Dehm et al.   CANCER RESEARCH

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH

In vivo Knockdown of the Androgen Receptor Results in Growth Inhibition and Regression of Well-Established, Castration-Resistant Prostate Tumors

(2008) R. Snoek et al.   CLINICAL CANCER RESEARCH

Structural basis for the nuclear import of the human androgen receptor

(2008) M. L. Cutress et al.   JOURNAL OF CELL SCIENCE

Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts

(2007) Heath E. Klock et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS