Genetic and epigenetic factors associated with increased severity of Covid‐19

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Coronavirus Disease 2019 (COVID-19): A Perspective from China

(2020) Zi Yue Zu et al.   RADIOLOGY

Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

(2020) Hannah Kleine-Weber et al.   Emerging Microbes & Infections

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

Why does COVID-19 disproportionately affect older people?

(2020) Amber L. Mueller et al.   Aging-US

Is global BCG vaccination‐induced trained immunity relevant to the progression of SARS‐CoV‐2 pandemic?

(2020) Mayda Gursel et al.   ALLERGY

COVID-19 pandemic, coronaviruses, and diabetes mellitus

(2020) Ranganath Muniyappa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rising to the Challenge of COVID-19: Advice for Pulmonary and Critical Care and an Agenda for Research

(2020) Michael S. Niederman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COVID-19 with Different Severities: A Multicenter Study of Clinical Features

(2020) Yun Feng et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Case Report: Death Due to Novel Coronavirus Disease (COVID-19) in Three Brothers

(2020) Sedigheh Yousefzadegan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?

(2020) Ahmed S. Abouhashem et al.   ANTIOXIDANTS & REDOX SIGNALING

A hypothesis for pathobiology and treatment of COVID‐19 : The centrality of ACE1 / ACE2 imbalance

(2020) Krishna Sriram et al.   BRITISH JOURNAL OF PHARMACOLOGY

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

(2020) Mihai G. Netea et al.   CELL

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

(2020) Jean-Laurent Casanova et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

COVID-19 infections are also affected by human ACE1 D/I polymorphism

(2020) Joris R. Delanghe et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

(2020)   EUROPEAN JOURNAL OF HUMAN GENETICS

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

COVID-19 pandemic: is a gender-defined dosage effect responsible for the high mortality rate among males?

(2020) Natasja G. de Groot et al.   IMMUNOGENETICS

COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations

(2020) Alireza Paniri et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

TMPRSS2: Potential Biomarker for COVID‐19 Outcomes

(2020) Jonathan D. Strope et al.   JOURNAL OF CLINICAL PHARMACOLOGY

CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China

(2020) Heng Meng et al.   JOURNAL OF INFECTION

Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

(2020) Yonghong Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

(2020) Mushtaq Hussain et al.   JOURNAL OF MEDICAL VIROLOGY

Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19

(2020) Hao Cheng et al.   JOURNAL OF MEDICAL VIROLOGY

ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome

(2020) Christian A. Devaux et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Human leukocyte antigen susceptibility map for SARS-CoV-2

(2020) Austin Nguyen et al.   JOURNAL OF VIROLOGY

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

(2020) Chia-Ling Kuo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Collapsing glomerulopathy in a COVID-19 patient

(2020) Sébastien Kissling et al.   KIDNEY INTERNATIONAL

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Does apolipoprotein E genotype predict COVID-19 severity?

(2020) M R Goldstein et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

(2020) Konrad H. Stopsack et al.   Cancer Discovery

Racial Variations in COVID‐19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti‐Androgens a Potential Treatment for COVID‐19?

(2020) John McCoy et al.   Journal of Cosmetic Dermatology

The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues

(2020) Behrooz Darbani   International Journal of Environmental Research and Public Health

The lethal sex gap: COVID-19

(2020) Eladio J. Márquez et al.   Immunity & Ageing

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections

(2020) Patricio L. Acosta et al.   Journal of Immunology Research

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease‐2019

(2020) Wei Wang et al.   HLA

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

ACE gene polymorphism and severe lung injury in patients with COVID-19

(2020) Haoyi Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Prevalence of Asymptomatic SARS-CoV-2 Infection

(2020) Daniel P. Oran et al.   ANNALS OF INTERNAL MEDICINE

Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents

(2020) Lalu Muhammad Irham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EZH2-mediated H3K27me3 inhibits ACE2 expression

(2020) Yuanyuan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

(2020) Yuan Hou et al.   BMC Medicine

ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population

(2020) Abhijit Pati et al.   CLINICA CHIMICA ACTA

The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections

(2020) Joris R. Delanghe et al.   CLINICA CHIMICA ACTA

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

(2020) Amr H. Sawalha et al.   CLINICAL IMMUNOLOGY

ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

(2020) Elisa Benetti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interleukin 6 polymorphisms as an indicator of COVID-19 severity in humans

(2020) Nikhil Kirtipal et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human

(2020) Sabyasachi Senapati et al.   JOURNAL OF GENETICS

ACE2, TMPRSS2 , and Furin variants and SARS‐CoV‐2 infection in Madrid, Spain

(2020) Laura Torre‐Fuentes et al.   JOURNAL OF MEDICAL VIROLOGY

''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?''

(2020) Hande Ikitimur et al.   JOURNAL OF MEDICAL VIROLOGY

Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank

(2020) Zahra Raisi-Estabragh et al.   JOURNAL OF PUBLIC HEALTH

AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL1 High-Risk Genotype

(2020) Huijuan Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank

(2020) Chia-Ling Kuo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The ApoE locus and COVID-19: are we going where we have been?

(2020) Caleb E Finch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Two hits to the renin‐angiotensin system may play a key role in severe COVID ‐19

(2020) Yu‐Hsin Tseng et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2

(2020) Anwar Mohammad et al.   LIFE SCIENCES

Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’

(2020) Enrico Lavezzo et al.   NATURE

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Venous thromboembolism in patients with COVID-19: Systematic review and meta-analysis

(2020) Angelo Porfidia et al.   THROMBOSIS RESEARCH

Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection

(2020) Soudeh Ghafouri-Fard et al.   VASCULAR PHARMACOLOGY

Targeting SARS-CoV-2 using polycomb inhibitors as antiviral agents

(2020) Sameer Ayaz et al.   Epigenomics

Management of epigenomic networks entailed in coronavirus infections and COVID-19

(2020) Ranim El Baba et al.   Clinical Epigenetics

The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients

(2020) Loris Zamai   Cells

ACE2 expression and sex disparity in COVID-19

(2020) Maria Cristina Gagliardi et al.   Cell Death Discovery

Acute Kidney Injury Due to Collapsing Glomerulopathy Following COVID-19 Infection

(2020) Yonatan Peleg et al.   Kidney International Reports

Collapsing Glomerulopathy in a Patient With COVID-19

(2020) Christopher P. Larsen et al.   Kidney International Reports

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19

(2020) Yuqin Wu et al.   CLINICA CHIMICA ACTA

Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19

(2020) Lucia Gabriele et al.   CYTOKINE & GROWTH FACTOR REVIEWS

SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype

(2020) Naoki Yamamoto et al.   GENE

Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection

(2020) Kristel Klaassen et al.   INFECTION GENETICS AND EVOLUTION

Identification of destabilizing SNPs in SARS-CoV2-ACE2 protein and spike glycoprotein: implications for virus entry mechanisms

(2020) Zoya Khalid et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

(2020) Xingyi Guo et al.   Journal of Translational Medicine

COVID-19: Thinking about further mental and neurological disorders

(2020) Renato Sobral Monteiro-Junior   MEDICAL HYPOTHESES

Genetic predisposition models to COVID-19 infection

(2020) Farzaneh Darbeheshti et al.   MEDICAL HYPOTHESES

Trained Innate Immunity, Epigenetics, and Covid-19

(2020) Alberto Mantovani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

ABO blood group, glycosyltransferase activity and risk of venous thromboembolism

(2020) Manal Ibrahim-Kosta et al.   THROMBOSIS RESEARCH

COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells

(2020) Andrea Latini et al.   Genes

Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome

(2020) C. Foresta et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

(2020) Daniel E Leisman et al.   Lancet Respiratory Medicine

Commentary: APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort

(2020) Kyle Kasparian et al.   Frontiers in Immunology

Angiotensin converting enzyme genotypes and mortality from COVID-19: An ecological study

(2020) Ar K Aung et al.   JOURNAL OF INFECTION

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

IFITM3: How genetics influence influenza infection demographically

(2019) Dannielle Wellington et al.   Biomedical Journal

CXCL16/CXCR6 is involved in LPS‐induced acute lung injury via P38 signalling

(2019) Guo‐wei Tu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Severe influenza pneumonitis in children with inherited TLR3 deficiency

(2019) Hye Kyung Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways

(2019) Alexander N. Wein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

(2018) Rob J.W. Arts et al.   Cell Host & Microbe

Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

(2018) C. Fernandez et al.   JOURNAL OF INTERNAL MEDICINE

HLA alleles modulate EBV viral load in multiple sclerosis

(2018) Simone Agostini et al.   Journal of Translational Medicine

X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation

(2018) Rafael Galupa et al.   Annual Review of Genetics

Epigenetic regulation of EC-SOD expression in aging lung fibroblasts: Role of histone acetylation

(2017) Jesse Roman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites

(2017) Y. Y. Chen et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Human IFNAR2 deficiency: Lessons for antiviral immunity

(2015) Christopher J. A. Duncan et al.   Science Translational Medicine

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

(2014) Raphael N. Vuille-dit-Bille et al.   AMINO ACIDS

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

Toll-Like Receptor Signaling

(2013) K.-H. Lim et al.   Cold Spring Harbor Perspectives in Biology

Population genetics of chronic kidney disease: The evolving story of APOL1

(2012) Walter G. Wasser et al.   JOURNAL OF NEPHROLOGY

Possession of HLA Class II DRB1*1303 Associates with Reduced Viral Loads in Chronic HIV-1 Clade C and B Infection

(2011) Boris Julg et al.   JOURNAL OF INFECTIOUS DISEASES