Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma

Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)

(2020) Deborah Quaglio et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

(2020) Francesca Mastrotto et al.   MOLECULAR PHARMACEUTICS

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

(2019) Francesca Bufalieri et al.   Nature Communications

Pharmacokinetics, Biodistribution, and Anti-Angiogenesis Efficacy of Diamino Propane Tetraiodothyroacetic Acid-conjugated Biodegradable Polymeric Nanoparticle

(2019) Weikun Li et al.   Scientific Reports

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

(2019) Giuseppina D’Alessandro et al.   Cell Communication and Signaling

Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies

(2018) Jun Wang et al.   Annual Review of Neuroscience

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

(2018) Simone Berardozzi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Control of Peptide Aggregation and Fibrillation by Physical PEGylation

(2018) Elena Ambrosio et al.   BIOMACROMOLECULES

Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

(2018) Maja Sabol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic delivery of siRNA by aminated poly( α )glutamate for the treatment of solid tumors

(2017) Dina Polyak et al.   JOURNAL OF CONTROLLED RELEASE

Pluronic F127 as a suitable carrier for preparing the imatinib base solid dispersions and its potential in development of a modified release dosage forms

(2017) Bożena Karolewicz et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapyin vitro

(2017) Cinzia Ingallina et al.   Nanomedicine

A novel combined strategy for the physical PEGylation of polypeptides

(2016) Elena Ambrosio et al.   JOURNAL OF CONTROLLED RELEASE

Pharmacokinetic drug interactions in liver disease: An update

(2016) Pietro Palatini   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

(2016) Paola Infante et al.   Cell Death & Disease

A novel performing PEG-cholane nanoformulation for Amphotericin B delivery

(2015) Claudia Luengo-Alonso et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeting GLI factors to inhibit the Hedgehog pathway

(2015) Paola Infante et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs

(2015) Bina Gidwani et al.   Biomed Research International

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

(2014) P. Infante et al.   EMBO JOURNAL

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

(2014) Chong Wang et al.   Nature Communications

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Self‐assembling nanocomposites for protein delivery: Supramolecular interactions between PEG‐cholane and rh‐G‐CSF

(2012) Stefano Salmaso et al.   JOURNAL OF CONTROLLED RELEASE

Molecular imaging of nuclear factor-Y transcriptional activity maps proliferation sites in live animals

(2012) Frauke Goeman et al.   MOLECULAR BIOLOGY OF THE CELL

Improving anti-tumor activity with polymeric micelles entrapping paclitaxel in pulmonary carcinoma

(2012) Changyang Gong et al.   Nanoscale

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

(2010) Elspeth M. Beauchamp et al.   JOURNAL OF CLINICAL INVESTIGATION

Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side Chain Chirality and Michael Acceptor Group for Maximal Potency

(2010) Chia-Hsien Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluvoxamine pharmacokinetics in healthy elderly subjects and elderly patients with chronic heart failure

(2009) Rocco Orlando et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen

(2009) Xinru Li et al.   Nanoscale Research Letters

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy

(2008) W.-Y. Au et al.   BLOOD

Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure

(2008) Hiromichi Kimura et al.   CANCER CELL

Secondary Structural Change of Bovine Serum Albumin in Thermal Denaturation up to 130 °C and Protective Effect of Sodium Dodecyl Sulfate on the Change

(2008) Yoshiko Moriyama et al.   JOURNAL OF PHYSICAL CHEMISTRY B