MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death

The role of SIRT1 in diabetic retinopathy

(2018) Hedyieh Karbasforooshan et al.   BIOMEDICINE & PHARMACOTHERAPY

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

(2018) Hao Wu et al.   JOURNAL OF ENDOCRINOLOGY

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

(2017) Weixia Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling

(2017) Ying Lin et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats

(2017) Lingling Zhao et al.   Therapeutics and Clinical Risk Management

0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop

(2017) Caixia Xia et al.   Scientific Reports

Therapeutic effect of pentoxifylline on reproductive parameters in diabetic male mice

(2016) S. A. Feyli et al.   ANDROLOGIA

C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21

(2016) Hao Wu et al.   DIABETOLOGIA

Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway

(2016) Huimin Lu et al.   DIABETOLOGIA

Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway

(2016) Yuping Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation

(2016) Yuguang Zhao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis

(2016) Ala` Abdelali et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis

(2015) Guohua Lou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

MicroRNA-34 Family and Its Role in Cardiovascular Disease

(2015) Na Li et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The Protective Effect of FGF21 on Diabetes-Induced Male Germ Cell Apoptosis Is Associated With Up-Regulated Testicular AKT and AMPK/Sirt1/PGC-1α Signaling

(2015) Xin Jiang et al.   ENDOCRINOLOGY

Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2

(2015) Hao Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin and metabolic kidney disease

(2015) Shu Wakino et al.   KIDNEY INTERNATIONAL

Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats

(2015) Iman Faid et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice

(2015) Hao Wu et al.   TOXICOLOGY LETTERS

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function

(2014) Yonggang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

(2014) Arun Baksi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

TBHP-induced oxidative stress alters microRNAs expression in mouse testis

(2014) Nayeralsadat Fatemi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much?

(2014) Sih Min Tan et al.   REDOX REPORT

Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function

(2014) Xin Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The p53/miR-34 axis in development and disease

(2014) M. Rokavec et al.   Journal of Molecular Cell Biology

Altering β-cell number through stable alteration of miR-21 and miR-34a expression

(2014) Marie Balslev Backe et al.   Islets

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Molecular mechanisms beyond glucose transport in diabetes-related male infertility

(2013) M.G. Alves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers

(2013) Sowmya Venkatasubramanian et al.   Journal of the American Heart Association

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

(2012) Ethan Hoffmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Laser-induced thrombus formation in mouse brain microvasculature: effect of clopidogrel

(2012) Takuya Fukuoka et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

(2012) Vincenzo Libri et al.   PLoS One

MicroRNAs in  -Cell Biology, Insulin Resistance, Diabetes and Its Complications

(2011) S. L. Fernandez-Valverde et al.   DIABETES

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice

(2010) Yuguang Zhao et al.   TOXICOLOGY LETTERS

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

(2009) M Lizé et al.   CELL DEATH AND DIFFERENTIATION

Inactivation of GSK-3  by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

(2009) Y. Wang et al.   DIABETES

Erectile Dysfunction in Diabetes Mellitus

(2009) Lasantha S. Malavige et al.   Journal of Sexual Medicine

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA