Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery

Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis

(2020) Ze-Xu Wei et al.   NEUROPSYCHOPHARMACOLOGY

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microRNA-26a expression

(2020) Huirong Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

(2020) Dongping Li et al.   Journal of Neuroinflammation

Mesocortical BDNF signaling mediates antidepressive-like effects of lithium

(2020) Di Liu et al.   NEUROPSYCHOPHARMACOLOGY

Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance

(2020) Carla Nasca et al.   MOLECULAR PSYCHIATRY

Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression

(2020) Wessel A. van Eeden et al.   Translational Psychiatry

Differential serum exosome microRNA profile in a stress-induced depression rat model

(2020) Ke Fang et al.   JOURNAL OF AFFECTIVE DISORDERS

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

(2019) Dorian A. Rosen et al.   Science Translational Medicine

Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway

(2019) Yun Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A-Kinase Anchoring Protein 150-PKA Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress

(2019) Hai-Yun Zhou et al.   BIOLOGICAL PSYCHIATRY

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway

(2019) Chao-jun Han et al.   ACTA PHARMACOLOGICA SINICA

Ketamine improved depressive-like behaviors via hippocampal glucocorticoid receptor in chronic stress induced- susceptible mice

(2019) Wei Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors

(2019) Rafaela Carneiro Cordeiro et al.   Frontiers in Psychiatry

Exosomes Derived From Septic Mouse Serum Modulate Immune Responses via Exosome-Associated Cytokines

(2019) Kun Gao et al.   Frontiers in Immunology

Effects of immunomodulatory drugs on depressive symptoms: A mega-analysis of randomized, placebo-controlled clinical trials in inflammatory disorders

(2019) Gayle M. Wittenberg et al.   MOLECULAR PSYCHIATRY

Circulating exosomal microRNAs in bipolar disorder

(2019) Deniz Ceylan et al.   JOURNAL OF AFFECTIVE DISORDERS

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

(2018) Jing Jing Li et al.   Journal of Neuroinflammation

Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

(2018) Jia Jia et al.   Frontiers in Cellular Neuroscience

Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes

(2018) Toru Hosoi et al.   Frontiers in Physiology

Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

(2017) Zhaoxiang Ren et al.   PSYCHOPHARMACOLOGY

Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress

(2016) Soshi Kanemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity

(2016) Yun Wang et al.   CNS Neuroscience & Therapeutics

Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

(2015) Zhuang Wu et al.   JOURNAL OF NEUROCHEMISTRY

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

(2012) Michiko Fujimoto et al.   SYNAPSE

Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue

(2011) J. C. Felger et al.   PSYCHOLOGICAL MEDICINE

Sigma receptors suppress multiple aspects of microglial activation

(2008) Aaron A. Hall et al.   GLIA

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus

(2008) Kazue Kikuchi-Utsumi et al.   NEUROSCIENCE LETTERS