Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance

Childhood trauma and insulin resistance in patients suffering from depressive disorders

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Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

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Pioglitazone reduces mortality, prevents depressive-like behavior, and impacts hippocampal neurogenesis in the 6-OHDA model of Parkinson's disease in rats

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Insulin resistance, an unmasked culprit in depressive disorders: Promises for interventions

(2018) Kathleen Watson et al.   NEUROPHARMACOLOGY

Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts

(2018) Carrie R. Ferrario et al.   NEUROPHARMACOLOGY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

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Acetyl-l-carnitine deficiency in patients with major depressive disorder

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An emerging epigenetic framework of systemic and central mechanisms underlying stress-related disorders

(2018) Carla Nasca et al.   NEUROPSYCHOPHARMACOLOGY

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress

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Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome

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Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

(2017) Maja Mustapic et al.   Frontiers in Neuroscience

Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant

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Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

(2016) Benedetta Bigio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

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Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity

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Association between insulin resistance and cognition in patients with depressive disorders: Exploratory analyses into age-specific effects

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Tumour exosome integrins determine organotropic metastasis

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Hippocampal insulin resistance and cognitive dysfunction

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Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice

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Adjuvant pioglitazone for unremitted depression: Clinical correlates of treatment response

(2015) Kathleen Watson Lin et al.   PSYCHIATRY RESEARCH

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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

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How does brain insulin resistance develop in Alzheimer's disease?

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The Epidemiology of Depression Across Cultures

(2013) Ronald C. Kessler et al.   Annual Review of Public Health

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine

(2013) Bruna Cuccurazzu et al.   NEUROPSYCHOPHARMACOLOGY

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

(2013) C. Nasca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuroprotective effects of GLP-1: Possible treatments for cognitive deficits in individuals with mood disorders

(2012) Roger S. McIntyre et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanisms for Insulin Resistance: Common Threads and Missing Links

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5′ end–centered expression profiling using cap-analysis gene expression and next-generation sequencing

(2012) Hazuki Takahashi et al.   Nature Protocols

Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease

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Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats

(2011) Claudia A. Grillo et al.   BEHAVIOURAL BRAIN RESEARCH

Rosiglitazone Add-On in Treatment of Depressed Patients with Insulin Resistance: a Pilot Study

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Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

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Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease

(2009) Natalie L. Rasgon et al.   NEUROBIOLOGY OF AGING

L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

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