Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity

Allosteric modulation of sigma-1 receptors elicits anti-seizure activities

(2015) Lin Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model

(2015) Zhi-Min Long et al.   CNS Neuroscience & Therapeutics

Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study

(2014) Shang-lin Zhou et al.   ACTA PHARMACOLOGICA SINICA

Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis

(2014) Hui Kong et al.   CNS Neuroscience & Therapeutics

The Effects of Dehydroepiandrosterone (DHEA) in the Treatment of Depression and Depressive Symptoms in Other Psychiatric and Medical Illnesses: A Systematic Review

(2014) Clayton Peixoto et al.   CURRENT DRUG TARGETS

Structural manipulation on the catecholic fragment of dopamine D1 receptor agonist 1-phenyl-N-methyl-benzazepines

(2014) Jing Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antidepressant-like effect of PRE-084, a selective σ1 receptor agonist, in Albino Swiss and C57BL/6J mice

(2014) Grażyna Skuza et al.   Pharmacological Reports

SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity

(2013) Xing Fang et al.   ACTA PHARMACOLOGICA SINICA

The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors

(2013) L Zvejniece et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain Sigma-1 Receptor Stimulation Improves Mental Disorder and Cardiac Function in Mice With Myocardial Infarction

(2013) Koji Ito et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Steroid hormones and BDNF

(2013) N. Pluchino et al.   NEUROSCIENCE

Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice

(2013) Shigeki Moriguchi et al.   PLoS One

Sigma-1 Receptor Enhances Neurite Elongation of Cerebellar Granule Neurons via TrkB Signaling

(2013) Yuriko Kimura et al.   PLoS One

Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression

(2012) Maha Elsayed et al.   BIOLOGICAL PSYCHIATRY

Chronic inhibition of glycogen synthase kinase-3 protects against rotenone-induced cell death in human neuron-like cells by increasing BDNF secretion

(2012) Alfredo Giménez-Cassina et al.   NEUROSCIENCE LETTERS

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression

(2012) Kenji Hashimoto   PROGRESS IN NEUROBIOLOGY

Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor

(2012) Michiko Fujimoto et al.   SYNAPSE

The sigma-1 receptor: roles in neuronal plasticity and disease

(2012) Saïd Kourrich et al.   TRENDS IN NEUROSCIENCES

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression

(2011) K. Ito et al.   CARDIOVASCULAR RESEARCH

Functional significance of glycogen synthase kinase-3 regulation by serotonin

(2011) Abigail M. Polter et al.   CELLULAR SIGNALLING

Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders

(2011) Teruo Hayashi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism

(2011) Hong-Yuan Chu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pharmacological Interaction With the Sigma1 (σ1)-Receptor in the Acute Behavioral Effects of Antidepressants

(2011) Vanessa Villard et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

(2010) Naoto Omata et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant-Like Effect of Venlafaxine Is Abolished in μ-Opioid Receptor–Knockout Mice

(2010) Soichiro Ide et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Association analysis of SIGMAR1 with major depressive disorder and SSRI response

(2010) Taro Kishi et al.   NEUROPHARMACOLOGY

Sigma receptors: Potential targets for a new class of antidepressant drug

(2010) James A. Fishback et al.   PHARMACOLOGY & THERAPEUTICS

Electrophysiological Effects of SKF83959 on Hippocampal CA1 Pyramidal Neurons: Potential Mechanisms for the Drug's Neuroprotective Effects

(2010) Hong-Yuan Chu et al.   PLoS One

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids

(2009) Subramaniam Ramachandran et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects

(2009) Xue-Qin Chen et al.   PLoS One

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

(2009) Shang-Yi Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sigma-1 receptor knockout mice display a depressive-like phenotype

(2008) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus

(2008) Kazue Kikuchi-Utsumi et al.   NEUROSCIENCE LETTERS

Glycogen synthase kinase-3β gene is associated with antidepressant treatment response in Chinese major depressive disorder

(2008) S-J Tsai et al.   PHARMACOGENOMICS JOURNAL