Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

(2020) William Binning et al.   BRAIN BEHAVIOR AND IMMUNITY

Chemogenetic Regulation of CX3CR1-Expressing Microglia Using Gi-DREADD Exerts Sex-Dependent Anti-Allodynic Effects in Mouse Models of Neuropathic Pain

(2020) Fumihiro Saika et al.   Frontiers in Pharmacology

Microglia: Lifelong patrolling immune cells of the brain

(2019) Ukpong B. Eyo et al.   PROGRESS IN NEUROBIOLOGY

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

(2019) Mikail Weston et al.   Science Advances

Designer receptor technology for the treatment of epilepsy

(2019) Andreas Lieb et al.   EBioMedicine

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

(2019) Jiyun Peng et al.   Molecular Brain

Identifying the variables that drive tamoxifen‐independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions

(2019) Hannah Van Hove et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

(2018) Peter M. Grace et al.   EXPERIMENTAL NEUROLOGY

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience

(2018) Ann-Kathrin Ilg et al.   Frontiers in Behavioral Neuroscience

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

(2017) Gang Chen et al.   Neuroscience Bulletin

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

(2017) Keisuke Koga et al.   Scientific Reports

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

(2016) Nan Gu et al.   BRAIN BEHAVIOR AND IMMUNITY

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

(2016) Hu Zhu et al.   GENESIS

Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons

(2016) Jami L. Saloman et al.   JOURNAL OF NEUROSCIENCE

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

(2016) Yong Liu et al.   JOURNAL OF NEUROSCIENCE

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

(2016) Yuji Nagai et al.   Nature Communications

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

(2016) Ryoichi Tashima et al.   Scientific Reports

Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types

(2016) Natale R. Sciolino et al.   Cell Reports

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

(2016) Nan Gu et al.   Cell Reports

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Selective Activation of Microglia Facilitates Synaptic Strength

(2015) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Modulation of the autonomic nervous system and behaviour by acute glial cell Gqprotein-coupled receptor activationin vivo

(2013) Cendra Agulhon et al.   JOURNAL OF PHYSIOLOGY-LONDON

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Neuronal and microglial mechanisms of neuropathic pain

(2011) Min Zhuo et al.   Molecular Brain

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Microglia and neuropathic pain

(2009) Kazuhide Inoue et al.   GLIA

Etodolac Attenuates Mechanical Allodynia in a Mouse Model of Neuropathic Pain

(2009) Naoki Inoue et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Selective Activation of Microglia in Spinal Cord but Not Higher Cortical Regions Following Nerve Injury in Adult Mouse

(2008) Fuxing Zhang et al.   Molecular Pain