Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics
Authors
Keywords
-
Journal
Science Advances
Volume 5, Issue 4, Pages eaaw1567
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-04-18
DOI
10.1126/sciadv.aaw1567
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Biochemical autoregulatory gene therapy for focal epilepsy
- (2018) Andreas Lieb et al. NATURE MEDICINE
- A randomized, 13-week study assessing the efficacy and metabolic effects of paliperidone palmitate injection and olanzapine in first-episode schizophrenia patients
- (2018) Manli Huang et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice
- (2018) Daniel F. Manvich et al. Scientific Reports
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Chemogenetics revealed: DREADD occupancy and activation via converted clozapine
- (2017) Juan L. Gomez et al. SCIENCE
- Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers
- (2017) Fei Tang et al. Frontiers in Neurology
- Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures
- (2016) Evan Wicker et al. EXPERIMENTAL NEUROLOGY
- DREADDs for Neuroscientists
- (2016) Bryan L. Roth NEURON
- The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs
- (2015) Xin Chen et al. ACS Chemical Neuroscience
- Changing channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitability
- (2015) Albert Snowball et al. FEBS LETTERS
- An analysis of the attrition of drug candidates from four major pharmaceutical companies
- (2015) Michael J. Waring et al. NATURE REVIEWS DRUG DISCOVERY
- ChEMBL web services: streamlining access to drug discovery data and utilities
- (2015) Mark Davies et al. NUCLEIC ACIDS RESEARCH
- Epilepsy surgery in children and adults
- (2014) Philippe Ryvlin et al. LANCET NEUROLOGY
- Chemical–genetic attenuation of focal neocortical seizures
- (2014) Dennis Kätzel et al. Nature Communications
- Classics in Chemical Neuroscience: Clozapine
- (2013) Cody J. Wenthur et al. ACS Chemical Neuroscience
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Metabolic Side-Effects of the Novel Second-Generation Antipsychotic Drugs Asenapine and Iloperidone: A Comparison with Olanzapine
- (2013) Heidi N. Boyda et al. PLoS One
- Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy
- (2012) R. C. Wykes et al. Science Translational Medicine
- Drug-Resistant Epilepsy
- (2011) Patrick Kwan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats
- (2010) Katrina Weston-Green et al. BEHAVIOURAL BRAIN RESEARCH
- Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures
- (2010) David P. D. Woldbye et al. BRAIN
- Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database
- (2010) Paul C. D. Hawkins et al. Journal of Chemical Information and Modeling
- Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates
- (2009) Patricia A Lawlor et al. MOLECULAR THERAPY
- Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
- (2008) Francesco Noè et al. BRAIN
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started