The role of water in the primary nucleation of protein amyloid aggregation

Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

(2020) Yi-Ping Chiu et al.   Nature Communications

WT and A53T α-Synuclein Systems: Melting Diagram and Its New Interpretation

(2020) Mónika Bokor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

Computational insights into the role of α-strand/sheet in aggregation of α-synuclein

(2019) Anand Balupuri et al.   Scientific Reports

Hyperosmotic stress induces cell-dependent aggregation of α-synuclein

(2019) Alexandra M. C. Fragniere et al.   Scientific Reports

The role of liquid-liquid phase separation in aggregation of the TDP-43 low complexity domain

(2019) W. Michael Babinchak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

(2019) Yanxian Lin et al.   eLife

Temperature, Hydrostatic Pressure, and Osmolyte Effects on Liquid-Liquid Phase Separation in Protein Condensates: Physical Chemistry and Biological Implications

(2019) Roland Hermann Alfons Winter et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tau local structure shields an amyloid-forming motif and controls aggregation propensity

(2019) Dailu Chen et al.   Nature Communications

The synergic effect of water and biomolecules in intracellular phase separation

(2019) Sara S. Ribeiro et al.   Nature Reviews Chemistry

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment

(2019) Liang Qu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Effect of Osmolytes on Conformational Behavior of Intrinsically Disordered Protein α-Synuclein

(2019) Ishrat Jahan et al.   BIOPHYSICAL JOURNAL

The role of water in amyloid aggregation kinetics

(2019) Amberley D Stephens et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles

(2018) Boris Y. Zaslavsky et al.   BIOCHEMISTRY

Femtosecond Hydration Map of Intrinsically Disordered α -Synuclein

(2018) Shruti Arya et al.   BIOPHYSICAL JOURNAL

Secondary nucleation in amyloid formation

(2018) Mattias Törnquist et al.   CHEMICAL COMMUNICATIONS

Hydration Water Distribution around Intrinsically Disordered Proteins

(2018) Leena Aggarwal et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

Physical basis of amyloid fibril polymorphism

(2018) William Close et al.   Nature Communications

Ganglioside lipids accelerate α-synuclein amyloid formation

(2018) Ricardo Gaspar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Molecular Dynamics Study to Investigate the Dimeric Structure of the Full-Length α-Synuclein in Aqueous Solution

(2017) Tingting Zhang et al.   Journal of Chemical Information and Modeling

Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium

(2017) Ryan Barnes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of solvent properties of water in crowding effects induced by macromolecular agents and osmolytes

(2017) L. A. Ferreira et al.   Molecular BioSystems

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct observation of structure and dynamics during phase separation of an elastomeric protein

(2017) Sean E. Reichheld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion protein dynamics before aggregation

(2017) Kinshuk Raj Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Signature of an aggregation-prone conformation of tau

(2017) Neil A. Eschmann et al.   Scientific Reports

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Molecular Shape and the Hydrophobic Effect

(2016) Matthew B. Hillyer et al.   Annual Review of Physical Chemistry

Intramolecular diffusion controls aggregation of the PAPf39 peptide

(2016) Kinshuk R. Srivastava et al.   BIOPHYSICAL CHEMISTRY

Water Determines the Structure and Dynamics of Proteins

(2016) Marie-Claire Bellissent-Funel et al.   CHEMICAL REVIEWS

Confined Water in Amyloid-Competent Oligomers of the Prion Protein

(2016) Vijit Dalal et al.   CHEMPHYSCHEM

Water Rearrangements upon Disorder-to-Order Amyloid Transition

(2016) Shruti Arya et al.   Journal of Physical Chemistry Letters

Dynamics of Seeded Aβ40-Fibril Growth from Atomistic Molecular Dynamics Simulations: Kinetic Trapping and Reduced Water Mobility in the Locking Step

(2016) Nadine Schwierz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phase behavior of lysozyme solutions in the liquid–liquid phase coexistence region at high hydrostatic pressures

(2016) Julian Schulze et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes

(2016) Hermann Broder Schmidt et al.   Cell Reports

Distinct Role of Hydration Water in Protein Misfolding and Aggregation Revealed by Fluctuating Thermodynamics Analysis

(2015) Song-Ho Chong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Local Structure and Dynamics of Hydration Water in Intrinsically Disordered Proteins

(2015) Pooja Rani et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau

(2015) Anna Pavlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydration water mobility is enhanced around tau amyloid fibers

(2015) Yann Fichou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins

(2015) Giorgio Schirò et al.   Nature Communications

Early Sodium Dodecyl Sulfate Induced Collapse of α-Synuclein Correlates with Its Amyloid Formation

(2014) Sujit Basak et al.   ACS Chemical Neuroscience

Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins

(2014) Song-Ho Chong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

(2014) Francois-Xavier Theillet et al.   CHEMICAL REVIEWS

Role of water in protein folding, oligomerization, amyloidosis and miniprotein

(2014) Tamás Vajda et al.   JOURNAL OF PEPTIDE SCIENCE

Ordered Water within the Collapsed Globules of an Amyloidogenic Intrinsically Disordered Protein

(2014) Shruti Arya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Presence of an Air–Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

(2014) Silvia Campioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Water Molecular System Dynamics Associated with Amyloidogenic Nucleation as Revealed by Real Time Near Infrared Spectroscopy and Aquaphotomics

(2014) Eri Chatani et al.   PLoS One

Dynamic hydration shell restores Kauzmann's 1959 explanation of how the hydrophobic factor drives protein folding

(2014) R. L. Baldwin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature-dependent solvation modulates the dimensions of disordered proteins

(2014) R. Wuttke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel β-Sheet Fibril and Antiparallel β-Sheet Oligomer: New Insights into Amyloid Formation of Hen Egg White Lysozyme under Heat and Acidic Condition from FTIR Spectroscopy

(2013) Ye Zou et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crowding Induced Collective Hydration of Biological Macromolecules over Extended Distances

(2013) John T. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth

(2012) Alexander K. Buell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Dynamical Coupling of Intrinsically Disordered Proteins and Their Hydration Water: Comparison with Folded Soluble and Membrane Proteins

(2012) F.-X. Gallat et al.   BIOPHYSICAL JOURNAL

A Desolvation Model for Trifluoroethanol-Induced Aggregation of Enhanced Green Fluorescent Protein

(2012) Valerie L. Anderson et al.   BIOPHYSICAL JOURNAL

Toward a Molecular Understanding of Protein Solubility: Increased Negative Surface Charge Correlates with Increased Solubility

(2012) Ryan M. Kramer et al.   BIOPHYSICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Interplay between desolvation and secondary structure in mediating cosolvent and temperature induced alpha-synuclein aggregation

(2012) V L Anderson et al.   PHYSICAL BIOLOGY

Aggregation of  -synuclein is kinetically controlled by intramolecular diffusion

(2012) B. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved features of intermediates in amyloid assembly determine their benign or toxic states

(2012) R. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Water in Protein Aggregation and Amyloid Polymorphism

(2011) D. Thirumalai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

(2011) Andrew J. Baldwin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein in α-helical conformation at air–water interface: implication of conformation and orientation changes during its accumulation/aggregation

(2010) Chengshan Wang et al.   CHEMICAL COMMUNICATIONS

Characterizing amyloid-beta protein misfolding from molecular dynamics simulations with explicit water

(2010) Chewook Lee et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

In Vitro Formation of Amyloid from α-Synuclein Is Dominated by Reactions at Hydrophobic Interfaces

(2010) Jeremy Pronchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires

(2010) G. Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide

(2009) Emilie Cerf et al.   BIOCHEMICAL JOURNAL

Importance of Translational Entropy of Water in Biological Self-Assembly Processes like Protein Folding

(2009) Masahiro Kinoshita   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Examining Polyglutamine Peptide Length: A Connection between Collapsed Conformations and Increased Aggregation

(2009) Robert H. Walters et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures and Thermodynamics of Alzheimer’s Amyloid-β Aβ(16−35) Monomer and Dimer by Replica Exchange Molecular Dynamics Simulations: Implication for Full-Length Aβ Fibrillation

(2009) Yassmine Chebaro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Dynamics of locking of peptides onto growing amyloid fibrils

(2009) G. Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Dynamics at the Protein-Water Interface from 17O Spin Relaxation in Deeply Supercooled Solutions

(2008) Carlos Mattea et al.   BIOPHYSICAL JOURNAL

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS

Amyloid β Conformation in Aqueous Environment

(2008) K. Takano   Current Alzheimer Research

Effect of Dehydration on the Aggregation Kinetics of Two Amyloid Peptides

(2008) Smita Mukherjee et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomerization and Aggregation of Bovine Pancreatic Ribonuclease A:Backbone Hydration Probed by Infrared Band-Shift

(2008) Jun Zhang et al.   PROTEIN AND PEPTIDE LETTERS