Role of A‐ and B‐type lamins in nuclear structure–function relationships

Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model

(2020) Jennifer C. Harr et al.   GENES & DEVELOPMENT

A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin

(2020) Oren Wintner et al.   Advanced Science

Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9

(2020) Mei-Yu Zhang et al.   EXPERIMENTAL CELL RESEARCH

Structure and unique mechanical aspects of nuclear lamin filaments

(2020) Rafael Tenga et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Interplay of lamin A and lamin B LADs on the radial positioning of chromatin

(2019) Frida Forsberg et al.   Nucleus

Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina

(2019) Bruce Nmezi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome–lamina interactions are established de novo in the early mouse embryo

(2019) Máté Borsos et al.   NATURE

The transcription factor Hey and nuclear lamins specify and maintain cell identity

(2019) Naama Flint Brodsly et al.   eLife

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

(2019) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

(2019) Natalie Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery

(2018) Xiaobin Zheng et al.   MOLECULAR CELL

Emerin modulates spatial organization of chromosome territories in cells on softer matrices

(2018) Roopali Pradhan et al.   NUCLEIC ACIDS RESEARCH

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

(2018) Simona Graziano et al.   Nucleus

Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

(2018) Simona Graziano et al.   Nucleus

Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

(2018) Laura Pascual-Reguant et al.   Nature Communications

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

(2017) Michael I. Robson et al.   GENOME RESEARCH

Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells

(2017) Sandra Vidak et al.   JOURNAL OF CELL SCIENCE

Lamins in the nuclear interior − life outside the lamina

(2017) Nana Naetar et al.   JOURNAL OF CELL SCIENCE

Lamin B1 regulates somatic mutations and progression of B-cell malignancies

(2017) T Klymenko et al.   LEUKEMIA

Lamin B2 Modulates Nucleolar Morphology, Dynamics, and Function

(2017) Ayantika Sen Gupta et al.   MOLECULAR AND CELLULAR BIOLOGY

Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

(2017) Amnon Buxboim et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

(2017) Rasmus Siersbæk et al.   MOLECULAR CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Identifying Novel Transcriptional and Epigenetic Features of Nuclear Lamina-associated Genes

(2017) Feinan Wu et al.   Scientific Reports

Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis

(2016) Callinice D. Capo-chichi et al.   BMC CELL BIOLOGY

Chromosomal aneuploidies induced upon Lamin B2 depletion are mislocalized in the interphase nucleus

(2016) Devika Ranade et al.   CHROMOSOMA

A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations

(2016) Wei Xie et al.   CURRENT BIOLOGY

Mechanotransduction and nuclear function

(2016) David M Graham et al.   CURRENT OPINION IN CELL BIOLOGY

Causes and consequences of nuclear envelope alterations in tumour progression

(2016) Emily S. Bell et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Nucleus and nucleus-cytoskeleton connections in 3D cell migration

(2016) Lingling Liu et al.   EXPERIMENTAL CELL RESEARCH

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Making the LINC: SUN and KASH protein interactions

(2015) Dae In Kim et al.   BIOLOGICAL CHEMISTRY

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

(2015) Christelle Lenain et al.   CARCINOGENESIS

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos

(2015) Adriana Gonzalez-Sandoval et al.   CELL

Networking in the nucleus: a spotlight on LEM-domain proteins

(2015) Lacy J Barton et al.   CURRENT OPINION IN CELL BIOLOGY

Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B

(2015) Torunn Rønningen et al.   GENOME RESEARCH

The lamin-A/C-LAP2 -BAF1 protein complex regulates mitotic spindle assembly and positioning

(2015) R. Qi et al.   JOURNAL OF CELL SCIENCE

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Lamins position the nuclear pores and centrosomes by modulating dynein

(2015) Yuxuan Guo et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis

(2015) Guanghui Gong et al.   PATHOLOGY RESEARCH AND PRACTICE

Loss of lamin A function increases chromatin dynamics in the nuclear interior

(2015) I. Bronshtein et al.   Nature Communications

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Nuclear envelope and genome interactions in cell fate

(2015) Jessica A. Talamas et al.   Frontiers in Genetics

Systems Mechanobiology: Tension-Inhibited Protein Turnover Is Sufficient to Physically Control Gene Circuits

(2014) P.C. Dave P. Dingal et al.   BIOPHYSICAL JOURNAL

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

(2014) Haiyang Chen et al.   CELL

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories

(2014) Jordi Camps et al.   FASEB JOURNAL

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Role of Lamin B1 in Chromatin Instability

(2014) Veronika Butin-Israeli et al.   MOLECULAR AND CELLULAR BIOLOGY

Mapping of protein- and chromatin-interactions at the nuclear lamina

(2014) Nard Kubben et al.   Nucleus

Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation

(2014) T Kuga et al.   Oncogenesis

Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila

(2013) Minoree Kohwi et al.   CELL

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes

(2013) E. Lund et al.   GENOME RESEARCH

Nuclear Structures Surrounding Internal Lamin Invaginations

(2013) Soňa Legartová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Nuclear lamins

(2013) Eivind Lund et al.   Nucleus

Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency

(2012) Lenka Stixová et al.   BIOLOGY OF THE CELL

Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway

(2012) Lu Kong et al.   CARCINOGENESIS

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

(2012) W. Meuleman et al.   GENOME RESEARCH

Lamin B Receptor Recognizes Specific Modifications of Histone H4 in Heterochromatin Formation

(2012) Yasuhiro Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

(2012) Laure Crabbe et al.   Cell Reports

The nuclear envelope proteome differs notably between tissues

(2012) Nadia Korfali et al.   Nucleus

A dual role for A-type lamins in DNA double-strand break repair

(2011) Abena B. Redwood et al.   CELL CYCLE

Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence

(2011) E.J.Th. Belt et al.   EUROPEAN JOURNAL OF CANCER

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

(2011) Catherine Coffinier et al.   MOLECULAR BIOLOGY OF THE CELL

Post-natal myogenic and adipogenic developmental

(2011) Nard Kubben et al.   Nucleus

Inheriting nuclear organization: can nuclear lamins impart spatial memory during post-mitotic nuclear assembly?

(2010) Catherine Martin et al.   CHROMOSOME RESEARCH

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Novel roles for A-type lamins in telomere biology and the DNA damage response pathway

(2009) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

A-type nuclear lamins act as transcriptional repressors when targeted to promoters

(2009) Damian C. Lee et al.   EXPERIMENTAL CELL RESEARCH

Lamin B1 controls oxidative stress responses via Oct-1

(2009) Ashraf N. Malhas et al.   JOURNAL OF CELL BIOLOGY

Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma

(2009) Zhengrong Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Barrier-to-autointegration factor (BAF) condenses DNA by looping

(2009) D. Skoko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The B-type lamin is required for somatic repression of testis-specific gene clusters

(2009) Y. Y. Shevelyov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lamin A: a putative colonic epithelial stem cell biomarker which identifies colorectal tumours with a more aggressive phenotype

(2008) Naomi D. Willis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?

(2008) Ishita S. Mehta et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope

(2008) José María González et al.   JOURNAL OF CELL BIOLOGY

Filaments made from A- and B-type lamins differ in structure and organization

(2008) M. W. Goldberg et al.   JOURNAL OF CELL SCIENCE

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

(2008) K. L. Reddy et al.   NATURE

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY