Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020

(2020) Jantien A Backer et al.   Eurosurveillance

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

LPS-binding IgG arrests actively motile Salmonella Typhimurium in gastrointestinal mucus

(2020) Holly A. Schroeder et al.   Mucosal Immunology

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

(2020) Xiaolong Tian et al.   Emerging Microbes & Infections

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

(2020) Xiangyu Chen et al.   Cellular & Molecular Immunology

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications

(2020) Joseph A. Roche et al.   FASEB JOURNAL

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

(2020) Tobias Herold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019

(2020) Qing-Lei Zeng et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Human neutralizing antibodies elicited by SARS-CoV-2 infection

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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine

(2020) Anna Z. Wec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Pulmonary fibrosis secondary to COVID-19: a call to arms?

(2020) Paolo Spagnolo et al.   Lancet Respiratory Medicine

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients

(2020) Christoph Kreer et al.   CELL

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike

(2020) Susmita Roy et al.   Journal of Physical Chemistry Letters

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

(2020) Antoni G. Wrobel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

(2020) Jiangdong Huo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

(2020) Johanna Hansen et al.   SCIENCE

Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination

(2020) Carl W. Davis et al.   SCIENCE

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

(2020) Philip J. M. Brouwer et al.   SCIENCE

Broad neutralization of SARS-related viruses by human monoclonal antibodies

(2020) Anna Z. Wec et al.   SCIENCE

The COVID-19 Cytokine Storm; What We Know So Far

(2020) Dina Ragab et al.   Frontiers in Immunology

Weathering the Cytokine Storm in Susceptible Patients with Severe SARS-CoV-2 Infection

(2020) Brian Lipworth et al.   Journal of Allergy and Clinical Immunology-In Practice

Future Trends in Nebulized Therapies for Pulmonary Disease

(2020) Sean D. McCarthy et al.   Journal of Personalized Medicine

Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID19 Patients

(2020) Larry L. Luchsinger et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Animal and translational models of SARS-CoV-2 infection and COVID-19

(2020) M. D. Johansen et al.   Mucosal Immunology

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

(2020) Donald J. Benton et al.   NATURE

Animal models for COVID-19

(2020) César Muñoz-Fontela et al.   NATURE

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

(2020) Bruce C. Trapnell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

(2020) Xiaojing Chi et al.   Nature Communications

Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding

(2020) James R. Byrnes et al.   mSphere

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura

(2019) Marie Scully et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study

(2019) Ellie Hershberger et al.   EBioMedicine

Antibody responses to viral infections: a structural perspective across three different enveloped viruses

(2019) Charles D. Murin et al.   Nature Microbiology

Exploring the fate of inhaled monoclonal antibody in the lung parenchyma by microdialysis

(2019) Antoine Guillon et al.   mAbs

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection

(2019) Carl W. Davis et al.   CELL

Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs

(2019) Worth Longest et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Efficacy and safety of inhaled alpha-1-antitrypsin in patients with severe alpha-1-antitrypsin deficiency and frequent exacerbations of Chronic Obstructive Pulmonary Disease

(2019) Jan Stolk et al.   EUROPEAN RESPIRATORY JOURNAL

The Therapeutic Potential of Nanobodies

(2019) Ivana Jovčevska et al.   BIODRUGS

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

(2019) Aimin Tang et al.   Nature Communications

901. MEDI8897 Prevents Serious RSV Disease in Healthy Preterm Infants

(2019) Mary Pamela Griffin et al.   Open Forum Infectious Diseases

Efficacy of an Inhaled Interleukin-13 Antibody Fragment in a Model of Chronic Asthma

(2018) Daniel Lightwood et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes

(2018) Jens Markus Borghardt et al.   Canadian Respiratory Journal

Designing inhaled protein therapeutics for topical lung delivery: what are the next steps?

(2018) Elsa Bodier-Montagutelli et al.   Expert Opinion on Drug Delivery

ZMapp Reinforces the Airway Mucosal Barrier Against Ebola Virus

(2018) Bing Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence and Significance of Substitutions in the Fusion Protein of Respiratory Syncytial Virus Resulting in Neutralization Escape From Antibody MEDI8897

(2018) Qing Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs

(2018) Alejandro Larios Mora et al.   mAbs

Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

(2018) Holly A. Schroeder et al.   Mucosal Immunology

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

(2018) Yanjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct cell-to-cell transmission of respiratory viruses: The fast lanes

(2018) Nicolás Cifuentes-Muñoz et al.   PLoS Pathogens

Evaluation of MEDI8852, an Anti-Influenza A Monoclonal Antibody, in Treating Acute Uncomplicated Influenza

(2018) S. Omar Ali et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intra-season Waning of Influenza Vaccine Effectiveness

(2018) G Thomas Ray et al.   CLINICAL INFECTIOUS DISEASES

Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2

(2018) Wenfei Song et al.   PLoS Pathogens

Randomized study of the safety and pharmacodynamics of inhaled interleukin-13 monoclonal antibody fragment VR942

(2018) Gary Burgess et al.   EBioMedicine

The micromechanics of lung alveoli: structure and function of surfactant and tissue components

(2018) Lars Knudsen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

(2017) Gino Van Heeke et al.   PHARMACOLOGY & THERAPEUTICS

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

(2017) Alexandra C. Walls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants

(2017) Qing Zhu et al.   Science Translational Medicine

A blueprint for robust crosslinking of mobile species in biogels with weakly adhesive molecular anchors

(2017) Jay Newby et al.   Nature Communications

Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus

(2016) Christine E. Henry et al.   Acta Biomaterialia

The formulation of nanomedicines for treating tuberculosis

(2016) Ana Costa et al.   ADVANCED DRUG DELIVERY REVIEWS

The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome

(2016) Tatiana Baranovich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding

(2016) Miao Gui et al.   CELL RESEARCH

Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections

(2016) Kimberly E. Hanson et al.   CLINICAL INFECTIOUS DISEASES

Influenza-binding antibodies immobilise influenza viruses in fresh human airway mucus

(2016) Ying-Ying Wang et al.   EUROPEAN RESPIRATORY JOURNAL

Protein stability in pulmonary drug delivery via nebulization

(2015) Sebastian P. Hertel et al.   ADVANCED DRUG DELIVERY REVIEWS

Direct Administration in the Respiratory Tract Improves Efficacy of Broadly Neutralizing Anti-Influenza Virus Monoclonal Antibodies

(2015) Victor H. Leyva-Grado et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nebulization as a delivery method for mAbs in respiratory diseases

(2015) Renaud Respaud et al.   Expert Opinion on Drug Delivery

Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients

(2015) Gregory S. Sawicki et al.   Journal of Cystic Fibrosis

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

(2015) Kristen E. Pascal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral Monoclonal Antibodies: Can They Be More Than Simple Neutralizing Agents?

(2015) Mireia Pelegrin et al.   TRENDS IN MICROBIOLOGY

The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial

(2014) Ratko Djukanović et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Broadly Neutralizing Influenza Hemagglutinin Stem-Specific Antibody CR8020 Targets Residues that Are Prone to Escape due to Host Selection Pressure

(2014) Kannan Tharakaraman et al.   Cell Host & Microbe

Fate of inhaled monoclonal antibodies after the deposition of aerosolized particles in the respiratory system

(2014) L. Guilleminault et al.   JOURNAL OF CONTROLLED RELEASE

Effect of formulation on the stability and aerosol performance of a nebulized antibody

(2014) Renaud Respaud et al.   mAbs

IgG in cervicovaginal mucus traps HSV and prevents vaginal Herpes infections

(2014) Y-Y Wang et al.   Mucosal Immunology

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

(2013) Gerald Nakamura et al.   Cell Host & Microbe

Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness

(2013) Octavio Ramilo et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Human Metapneumovirus

(2013) J. E. Schuster et al.   PEDIATRICS IN REVIEW

Sensitive Detection Assays for Influenza RNA Do Not Reveal Viremia in US Blood Donors

(2012) Susan L. Stramer et al.   JOURNAL OF INFECTIOUS DISEASES

The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation

(2012) Daniel Lightwood et al.   JOURNAL OF MOLECULAR BIOLOGY

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

(2012) D. R. Burton et al.   SCIENCE

What the pulmonary specialist should know about the new inhalation therapies

(2011) B. L. Laube et al.   EUROPEAN RESPIRATORY JOURNAL

Influence of particle size on regional lung deposition – What evidence is there?

(2011) Thiago C. Carvalho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Apical Transport of Influenza A Virus Ribonucleoprotein Requires Rab11-positive Recycling Endosome

(2011) Fumitaka Momose et al.   PLoS One

Clinical and Virological Factors Associated with Viremia in Pandemic Influenza A/H1N1/2009 Virus Infection

(2011) Herman Tse et al.   PLoS One

Correction: FilmArray, an Automated Nested Multiplex PCR System for Multi-Pathogen Detection: Development and Application to Respiratory Tract Infection

(2011) Mark A. Poritz et al.   PLoS One

The I-neb Adaptive Aerosol Delivery System Enhances Delivery of α1-Antitrypsin with Controlled Inhalation

(2010) David E. Geller et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Mode of Breathing—Tidal or Slow and Deep—through the I-neb Adaptive Aerosol Delivery (AAD) System Affects Lung Deposition of 99mTc-DTPA

(2010) Kurt Nikander et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

The Rab11 Pathway Is Required for Influenza A Virus Budding and Filament Formation

(2010) E. A. Bruce et al.   JOURNAL OF VIROLOGY

Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures

(2010) K. Pyrc et al.   JOURNAL OF VIROLOGY

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

Lung Deposition of a Liposomal Cyclosporine A Inhalation Solution in Patients after Lung Transplantation

(2009) Juergen Behr et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk Children: A Noninferiority Trial

(2009) X. Carbonell-Estrany et al.   PEDIATRICS

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Vaccines: Correlates of Vaccine‐Induced Immunity

(2008) Stanley A. Plotkin   CLINICAL INFECTIOUS DISEASES

Rapid pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: A pilot project

(2008) Allan L Coates et al.   PEDIATRIC PULMONOLOGY

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Pulmonary Drug Delivery System for inhalation therapy in mechanically ventilated patients

(2007) Rajiv Dhand et al.   Expert Review of Medical Devices