Animal and translational models of SARS-CoV-2 infection and COVID-19

Critical role for iron accumulation in the pathogenesis of fibrotic lung disease

(2020) Md Khadem Ali et al.   JOURNAL OF PATHOLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age

(2020) Katarzyna Bilinska et al.   ACS Chemical Neuroscience

Why does COVID-19 disproportionately affect older people?

(2020) Amber L. Mueller et al.   Aging-US

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

(2020) Junwen Luan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

(2020) Ren-Di Jiang et al.   CELL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

(2020) Jean-Laurent Casanova et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

(2020) Young-Il Kim et al.   Cell Host & Microbe

A Dynamic Immune Response Shapes COVID-19 Progression

(2020) Eugenia Ziying Ong et al.   Cell Host & Microbe

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion

(2020) Xinling Wang et al.   Cellular & Molecular Immunology

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein

(2020) Hong Zhou et al.   CURRENT BIOLOGY

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

(2020) Joan C. Smith et al.   DEVELOPMENTAL CELL

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

(2020) Rong-Hui Du et al.   EUROPEAN RESPIRATORY JOURNAL

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

(2020) Jing Yang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

(2020) Xiaochen Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Severe Covid-19

(2020) David A. Berlin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

(2020) Mandeep R. Mehra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transmission of SARS-CoV-2 in Domestic Cats

(2020) Peter J. Halfmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevalence, Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis

(2020) Jaber S. Alqahtani et al.   PLoS One

Pathogen reduction of SARS-CoV-2 virus in plasma and whole blood using riboflavin and UV light

(2020) Izabela Ragan et al.   PLoS One

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

(2020) Jingyou Yu et al.   SCIENCE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Covid-19: risk factors for severe disease and death

(2020) Rachel E Jordan et al.   BMJ-British Medical Journal

Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study

(2020) Christopher M Petrilli et al.   BMJ-British Medical Journal

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

(2020) Tao Chen et al.   BMJ-British Medical Journal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

(2020) Peter M George et al.   Lancet Respiratory Medicine

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020

(2020) Shikha Garg et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

An Extensive Meta-Metagenomic Search Identifies SARS-CoV-2-Homologous Sequences in Pangolin Lung Viromes

(2020) Lamia Wahba et al.   mSphere

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Diabetes increases the mortality of patients with COVID-19: a meta-analysis

(2020) Zeng-hong Wu et al.   ACTA DIABETOLOGICA

Coronavirus surveillance of wildlife in the Lao People’s Democratic Republic detects viral RNA in rodents

(2020) David J. McIver et al.   ARCHIVES OF VIROLOGY

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

SARS-CoV-2 and diabetes: New challenges for the disease

(2020) Cecília Cristelo et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020

(2020) Nadia Oreshkova et al.   Eurosurveillance

Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis

(2020) Qianwen Zhao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Early evidence of pronounced brain involvement in fatal COVID-19 outcomes

(2020) Claus Hann von Weyhern et al.   LANCET

COVID ‐19 acute respiratory distress syndrome ( ARDS ): clinical features and differences from typical pre‐ COVID ‐19 ARDS

(2020) Peter G Gibson et al.   MEDICAL JOURNAL OF AUSTRALIA

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

(2020) Neeltje van Doremalen et al.   NATURE

New-Onset Diabetes in Covid-19

(2020) Francesco Rubino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID‐19

(2020) Natasha N. Pettit et al.   Obesity

Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions

(2020) Yingjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

First detection and genome sequencing of SARS‐CoV‐2 in an infected cat in France

(2020) Corinne Sailleau et al.   Transboundary and Emerging Diseases

Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study

(2020) Andrew Clark et al.   Lancet Global Health

First Reported Cases of SARS-CoV-2 Infection in Companion Animals — New York, March–April 2020

(2020) Alexandra Newman et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis

(2020) Ian Huang et al.   Journal of Intensive Care

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities

(2020) Louis Maximilian Buja et al.   CARDIOVASCULAR PATHOLOGY

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in Chronic Obstructive Pulmonary Disease

(2019) Alen Faiz et al.   EUROPEAN RESPIRATORY JOURNAL

The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions

(2019) Kelsey E. Noll et al.   Cell Host & Microbe

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

(2019) MengJie Hu et al.   eLife

Syrian Hamster as an Animal Model for the Study on Infectious Diseases

(2019) Jinxin Miao et al.   Frontiers in Immunology

Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica)

(2019) Ping Liu et al.   Viruses-Basel

Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets

(2018) Emmie de Wit et al.   ANTIVIRAL RESEARCH

MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

(2018) Waleed H. Mahallawi et al.   CYTOKINE

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9

(2018) Jinxin Miao et al.   Viruses-Basel

Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

(2017) Philip M. Hansbro et al.   IMMUNOLOGICAL REVIEWS

Characterization of ACE and ACE2 Expression within Different Organs of the NOD Mouse

(2017) Heleia Roca-Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

(2017) Gang Liu et al.   JOURNAL OF PATHOLOGY

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

(2017) Kun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

(2017) Lukasz Kedzierski et al.   eLife

Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?

(2017) Katina D. Hulme et al.   Frontiers in Microbiology

Protecting Poultry Workers from Exposure to Avian Influenza Viruses

(2017) Kathleen L. MacMahon et al.   PUBLIC HEALTH REPORTS

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to  -adrenoceptor agonists in mouse lung

(2016) C. Donovan et al.   CLINICAL SCIENCE

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of COPD: What do they tell us?

(2016) Bernadette Jones et al.   RESPIROLOGY

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

(2016) Adam S. Cockrell et al.   Nature Microbiology

Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)

(2016) Vincent J. Munster et al.   Scientific Reports

Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease

(2015) Alan Chen-Yu Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Anurodh Shankar Agrawal et al.   JOURNAL OF VIROLOGY

Ferret models of viral pathogenesis

(2015) T. Enkirch et al.   VIROLOGY

Animal models for SARS and MERS coronaviruses

(2015) Lisa M Gretebeck et al.   Current Opinion in Virology

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

(2015) Lisa E. Gralinski et al.   PLoS Genetics

Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung

(2015) Hock L. Tay et al.   PLoS Pathogens

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

(2015) Karoly Toth et al.   PLoS Pathogens

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Influenza Virus Propagation in Embryonated Chicken Eggs

(2015) Rena Brauer et al.   Jove-Journal of Visualized Experiments

Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis

(2014) Philip M. Hansbro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronaviruses: Important Emerging Human Pathogens

(2014) C. M. Coleman et al.   JOURNAL OF VIROLOGY

Host Species Restriction of Middle East Respiratory Syndrome Coronavirus through Its Receptor, Dipeptidyl Peptidase 4

(2014) N. van Doremalen et al.   JOURNAL OF VIROLOGY

Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. Barlan et al.   JOURNAL OF VIROLOGY

Mouse Dipeptidyl Peptidase 4 Is Not a Functional Receptor for Middle East Respiratory Syndrome Coronavirus Infection

(2014) A. S. Cockrell et al.   JOURNAL OF VIROLOGY

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset

(2014) Darryl Falzarano et al.   PLoS Pathogens

Rho-Associated Protein Kinase Inhibition Enhances Airway Epithelial Basal-Cell Proliferation and Lentivirus Transduction

(2013) Amjad Horani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus

(2013) Y. Yao et al.   JOURNAL OF INFECTIOUS DISEASES

Complete Protection against Severe Acute Respiratory Syndrome Coronavirus-Mediated Lethal Respiratory Disease in Aged Mice by Immunization with a Mouse-Adapted Virus Lacking E Protein

(2013) C. Fett et al.   JOURNAL OF VIROLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Pneumonia from Human Coronavirus in a Macaque Model

(2013) Vincent J. Munster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

(2013) E. de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population

(2012)   GENETICS

Critical Role of Constitutive Type I Interferon Response in Bronchial Epithelial Cell to Influenza Infection

(2012) Alan C-Y. Hsu et al.   PLoS One

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

(2012) Marco Schlepütz et al.   PLoS One

Transcriptome Sequencing and Annotation for the Jamaican Fruit Bat (Artibeus jamaicensis)

(2012) Timothy I. Shaw et al.   PLoS One

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

(2011) Chenggang Li et al.   CELL RESEARCH

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus Macaques

(2011) Barry Rockx et al.   PLoS One

Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

(2010) Jason Netland et al.   VIROLOGY

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

(2010) Saskia L. Smits et al.   PLoS Pathogens

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

(2010) Matthew B. Frieman et al.   PLoS Pathogens

House Dust Mite–Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium

(2009) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

(2009) Craig W. Day et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

Effect of Perinatal secondhand tobacco smoke exposure on in vivo and intrinsic airway structure/function in non-human primates

(2008) Jesse P. Joad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pathology of Experimental SARS Coronavirus Infection in Cats and Ferrets

(2008) J. M. A. van den Brand et al.   VETERINARY PATHOLOGY

An immunosuppressed Syrian golden hamster model for SARS-CoV infection

(2008) Scott R. Schaecher et al.   VIROLOGY

The SARS-CoV ferret model in an infection–challenge study

(2008) Yong-Kyu Chu et al.   VIROLOGY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL