Structural Insights into Substrate Recognition and Processing by the 20S Proteasome

Exploring long-range cooperativity in the 20S proteasome core particle from Thermoplasma acidophilum using methyl-TROSY–based NMR

(2020) Enrico Rennella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond cells: The extracellular circulating 20S proteasomes

(2020) Vandita Dwivedi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms of substrate recognition by the 26S proteasome

(2020) Caroline Davis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intracellular Peptides in Cell Biology and Pharmacology

(2019) de Araujo et al.   Biomolecules

The Contribution of the 20S Proteasome to Proteostasis

(2019) Fanindra Kumar Deshmukh et al.   Biomolecules

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

(2019) Ana Toste Rêgo et al.   MOLECULAR CELL

Proteasomes: unfoldase-assisted protein degradation machines

(2019) Parijat Majumder et al.   BIOLOGICAL CHEMISTRY

New addiction to the NRF2‐related factor NRF3 in cancer cells: Ubiquitin‐independent proteolysis through the 20S proteasome

(2019) Akira Kobayashi et al.   CANCER SCIENCE

Understanding the 26S proteasome molecular machine from a structural and conformational dynamics perspective

(2019) Eric R Greene et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Small Molecule Modulation of Proteasome Assembly

(2018) Evert Njomen et al.   BIOCHEMISTRY

Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

(2018) Richard S Marshall et al.   eLife

The physiological role of the free 20S proteasome in protein degradation: A critical review

(2018) Marilene Demasi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Disordered Landscape of the 20S Proteasome Substrates Reveals Tight Association with Phase Separated Granules

(2018) Nadav Myers et al.   PROTEOMICS

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle

(2018) Parijat Majumder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

Proteasome Structure and Assembly

(2017) Lauren Budenholzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase

(2017) L E Giono et al.   ONCOGENE

Tuning the proteasome to brighten the end of the journey

(2016) Thibault Mayor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The proteasome subunit RPN10 functions as a specific receptor for degradation of the 26S proteasome by macroautophagy inArabidopsis

(2016) Xin Wen et al.   Autophagy

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

Analysis of the Yeast Peptidome and Comparison with the Human Peptidome

(2016) Sayani Dasgupta et al.   PLoS One

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

(2016) Victoria Cohen-Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

(2016) Eva M. Huber et al.   Nature Communications

Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

(2016) Won Hoon Choi et al.   Nature Communications

Nanomechanics of Protein Unfolding Outside a Generic Nanopore

(2015) Binquan Luan et al.   ACS Nano

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Evolution of Proteasome Regulators in Eukaryotes

(2015) Philippe Fort et al.   Genome Biology and Evolution

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

(2015) Richard S. Marshall et al.   MOLECULAR CELL

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

(2015) Peter Tsvetkov et al.   eLife

Harnessing Proteasome Dynamics and Allostery in Drug Design

(2014) Maria Gaczynska et al.   ANTIOXIDANTS & REDOX SIGNALING

20S proteasome activity is modified via S-glutathionylation based on intracellular redox status of the yeast Saccharomyces cerevisiae: Implications for the degradation of oxidized proteins

(2014) Marilene Demasi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Proteasome assembly

(2014) Zhu Chao Gu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PA28αβ Reduces Size and Increases Hydrophilicity of 20S Immunoproteasome Peptide Products

(2014) Mary Raule et al.   CHEMISTRY & BIOLOGY

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

(2014) H. C. Besche et al.   EMBO JOURNAL

Label-Free Quantitative Proteomics Reveals the Dynamics of Proteasome Complexes Composition and Stoichiometry in a Wide Range of Human Cell Lines

(2014) Bertrand Fabre et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial dysfunction and oxidative stress in CHF

(2014) Darlington O. Okonko et al.   Nature Reviews Cardiology

Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells

(2014) Sayani Dasgupta et al.   PLoS One

Architecture and assembly of the archaeal Cdc48*20S proteasome

(2014) D. Barthelme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible 26S Proteasome Disassembly upon Mitochondrial Stress

(2014) Nurit Livnat-Levanon et al.   Cell Reports

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Molecular Architecture and Assembly of the Eukaryotic Proteasome

(2013) Robert J. Tomko et al.   Annual Review of Biochemistry

Impaired Assembly and Post-translational Regulation of 26S Proteasome in Human End-Stage Heart Failure

(2013) Sharlene M. Day et al.   Circulation-Heart Failure

Formation and dissociation of proteasome storage granules are regulated by cytosolic pH

(2013) Lee Zeev Peters et al.   JOURNAL OF CELL BIOLOGY

System-wide Analysis Reveals Intrinsically Disordered Proteins Are Prone to Ubiquitylation after Misfolding Stress

(2013) Alex H. M. Ng et al.   MOLECULAR & CELLULAR PROTEOMICS

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

(2013) Tobias Jung et al.   Redox Biology

Redox regulation of the proteasome via S-glutathionylation

(2013) Marilene Demasi et al.   Redox Biology

Redox Control of 20S Proteasome Gating

(2012) Gustavo M. Silva et al.   ANTIOXIDANTS & REDOX SIGNALING

A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster

(2012) A. M. Pickering et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Identification of the Cdc48bullet20S Proteasome as an Ancient AAA+ Proteolytic Machine

(2012) D. Barthelme et al.   SCIENCE

Proteasome Activator 200: The HEAT is on…

(2011) Anca F. Savulescu et al.   MOLECULAR & CELLULAR PROTEOMICS

Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates

(2011) Peter Tsvetkov et al.   Molecular BioSystems

Context-dependent resistance to proteolysis of intrinsically disordered proteins

(2011) Marcin J. Suskiewicz et al.   PROTEIN SCIENCE

Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions

(2010) Tilman Grune et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ubiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies

(2010) Jaime M. Predmore et al.   CIRCULATION

The C Terminus of Rpt3, an ATPase Subunit of PA700 (19 S) Regulatory Complex, Is Essential for 26 S Proteasome Assembly but Not for Activation

(2010) Brajesh Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

(2010) Kianoush Sadre-Bazzaz et al.   MOLECULAR CELL

Regulation of the 26S Proteasome Complex During Oxidative Stress

(2010) X. Wang et al.   Science Signaling

The 20S Proteasome as an Assembly Platform for the 19S Regulatory Complex

(2009) Klavs B. Hendil et al.   JOURNAL OF MOLECULAR BIOLOGY

The nanny model for IDPs

(2009) Peter Tsvetkov et al.   Nature Chemical Biology

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel

(2009) Pawel A. Osmulski et al.   STRUCTURE

The proteasome and its role in the degradation of oxidized proteins

(2008) Tobias Jung et al.   IUBMB LIFE

Structure of the Human 26S Proteasome

(2008) Paula C. A. da Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Roles of the COOH Termini of AAA Subunits of PA700 (19 S Regulator) in Asymmetric Assembly and Activation of the 26 S Proteasome

(2008) Thomas G. Gillette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28 -Dependent Mechanism

(2008) R. Suzuki et al.   JOURNAL OF VIROLOGY

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking

(2008) Véronique Baldin et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism of Gate Opening in the 20S Proteasome by the Proteasomal ATPases

(2008) Julius Rabl et al.   MOLECULAR CELL