Intracellular Peptides in Cell Biology and Pharmacology

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

(2019) Julio C. B. Ferreira et al.   Nature Communications

Pep5, a fragment of cyclin D2, shows antiparasitic effects in different stages of the Trypanosoma cruzi life cycle and blocks parasite infectivity

(2019) Christiane Bezerra de Araujo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain

(2019) Caio Matheus Manzi Teixeira et al.   Zebrafish

CB 1 cannabinoid receptor agonist mouse VD-hemopressin(α) produced supraspinal analgesic activity in the preclinical models of pain

(2018) Ting Zheng et al.   BRAIN RESEARCH

Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice

(2018) Pei Wang et al.   BRAIN RESEARCH BULLETIN

Effects of central RVD-hemopressin(α) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat

(2018) Lucia Recinella et al.   Pharmacological Reports

Correction: Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states

(2018) Andrea S. Heimann et al.   PLoS One

The immunoproteasome and thymoproteasome: functions, evolution and human disease

(2018) Shigeo Murata et al.   NATURE IMMUNOLOGY

Identification of intracellular peptides associated with thermogenesis in human brown adipocytes

(2018) Yun Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells

(2017) Lilian C. Russo et al.   Journal of Proteomics

Peptidomic analysis of the anterior temporal lobe and corpus callosum from schizophrenia patients

(2017) C.C. Café-Mendes et al.   Journal of Proteomics

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats

(2017) Sheila Leone et al.   Pharmacological Reports

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel peptide that improves metabolic parameters without adverse central nervous system effects

(2017) Patrícia Reckziegel et al.   Scientific Reports

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Emerging biological roles of Cl−intracellular channel proteins

(2016) Elisabetta Argenzio et al.   JOURNAL OF CELL SCIENCE

Cyclin D1, cancer progression, and opportunities in cancer treatment

(2016) Shuo Qie et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Analysis of the Yeast Peptidome and Comparison with the Human Peptidome

(2016) Sayani Dasgupta et al.   PLoS One

Further Characterization of Hemopressin Peptide Fragments in the Opioid and Cannabinoid Systems

(2015) Eszter Szlavicz et al.   ANESTHESIA AND ANALGESIA

Specific pools of endogenous peptides are present in gametophore, protonema, and protoplast cells of the moss Physcomitrella patens

(2015) Igor A Fesenko et al.   BMC PLANT BIOLOGY

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

Site-specific Substitutions Eliminate Aggregation Properties of Hemopressin

(2015) Benben Song et al.   Chemical Biology & Drug Design

Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice

(2015) Jia-Xin Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Analysis of Major Histocompatibility Complex (MHC) Immunopeptidomes Using Mass Spectrometry

(2015) Etienne Caron et al.   MOLECULAR & CELLULAR PROTEOMICS

Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors

(2015) Sahar El Swefy et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla

(2015) Stefanie C. Hofer et al.   NEUROPHARMACOLOGY

Intracellular postsynaptic cannabinoid receptors link thyrotropin-releasing hormone receptors to TRPC-like channels in thalamic paraventricular nucleus neurons

(2015) L. Zhang et al.   NEUROSCIENCE

Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model

(2015) Alex Straiker et al.   PHARMACOLOGICAL RESEARCH

Anxiogenic-like effects induced by hemopressin in rats

(2015) Manoela V. Fogaça et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions

(2015) Lei Ma et al.   Scientific Reports

Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington’s Disease

(2015) Sayani Dasgupta et al.   PLoS One

Chloride Intracellular Channel 1 Regulates Prostate Cancer Cell Proliferation and Migration Through the MAPK/ERK Pathway

(2014) Yudong Tian et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress

(2014) F Vallelian et al.   CELL DEATH AND DIFFERENTIATION

Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats

(2014) Mona F. Mahmoud et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Novel Intracellular Peptide Derived from G1/S Cyclin D2 Induces Cell Death

(2014) Christiane B. de Araujo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurolysin Knockout Mice Generation and Initial Phenotype Characterization

(2014) Diogo M. L. P. Cavalcanti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidomic analysis of the neurolysin-knockout mouse brain

(2014) Leandro M. Castro et al.   Journal of Proteomics

Early phytocannabinoid chemistry to endocannabinoids and beyond

(2014) Raphael Mechoulam et al.   NATURE REVIEWS NEUROSCIENCE

Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice

(2014) Jia-Xin Pan et al.   NEUROSCIENCE LETTERS

Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats

(2014) Elaine F. Toniolo et al.   PEPTIDES

The hypotensive effect of intrathecally injected (m)VD-hemopressin(α) in urethane-anesthetized rats

(2014) Xu-hui Li et al.   PEPTIDES

Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells

(2014) Sayani Dasgupta et al.   PLoS One

Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway

(2014) Pan Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

(2014) Sara Xapelli et al.   Frontiers in Cellular Neuroscience

Analysis of peptides secreted from cultured mouse brain tissue

(2013) Julia S. Gelman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat

(2013) Kenjiro Tanaka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcriptome study of differential expression in schizophrenia

(2013) Alan R. Sanders et al.   HUMAN MOLECULAR GENETICS

Efficient computation of root mean square deviations under rigid transformations

(2013) Anna K. Hildebrandt et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

HLA Peptide Length Preferences Control CD8+ T Cell Responses

(2013) M. J. Rist et al.   JOURNAL OF IMMUNOLOGY

Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain

(2013) Mamoon Rashid et al.   JOURNAL OF NEUROCHEMISTRY

HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B*57 That Is Distinct from HLA-B*58:01

(2013) H. N. Kloverpris et al.   JOURNAL OF VIROLOGY

Central functional response to the novel peptide cannabinoid, hemopressin

(2013) Garron T. Dodd et al.   NEUROPHARMACOLOGY

AGH is a new hemoglobin alpha-chain fragment with antinociceptive activity

(2013) Natalia M. Ribeiro et al.   PEPTIDES

Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib

(2013) Julia S. Gelman et al.   PLoS One

The Effects of Peptide and Lipid Endocannabinoids on Arthritic Pain at the Spinal Level

(2012) Zita Petrovszki et al.   ANESTHESIA AND ANALGESIA

Hemopressin Forms Self-Assembled Fibrillar Nanostructures under Physiologically Relevant Conditions

(2012) Martha G. Bomar et al.   BIOMACROMOLECULES

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction

(2012) Lilian C. Russo et al.   FEBS LETTERS

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1Receptors

(2012) Mark Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical ubiquitin-based signals for proteasomal degradation

(2012) Y. Kravtsova-Ivantsiv et al.   JOURNAL OF CELL SCIENCE

Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides

(2012) Lloyd D. Fricker et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of the cannabinoid receptors by hemopressin peptides

(2012) Martha G. Bomar et al.   LIFE SCIENCES

Effects of endokinin A/B and endokinin C/D on the antinociception properties of hemopressin in mice

(2012) Lanxia Zhou et al.   PEPTIDES

Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance

(2012) Denise A. Berti et al.   PROTEOMICS

Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3ε and calmodulin

(2012) Lilian C. Russo et al.   PROTEOMICS

Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain

(2011) Aldric Hama et al.   BRAIN RESEARCH

Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery

(2011) Harsh Pawar et al.   CANCER BIOLOGY & THERAPY

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands

(2011) Brian P. Dolan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inverse agonism and its therapeutic significance

(2011) Gurudas Khilnani et al.   INDIAN JOURNAL OF PHARMACOLOGY

Peptidomic Analysis of Human Cell Lines

(2011) Julia S. Gelman et al.   JOURNAL OF PROTEOME RESEARCH

Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma

(2011) Koji Katada et al.   Journal of Proteomics

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

An asymmetric interface between the regulatory and core particles of the proteasome

(2011) Geng Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Centrally mediated antinociceptive effects of cannabinoid receptor ligands in rat models of nociception

(2011) Aldric Hama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Hemoglobin-derived Peptides as Novel Type of Bioactive Signaling Molecules

(2010) Ivone Gomes et al.   AAPS Journal

Hemopressin and Other Bioactive Peptides from Cytosolic Proteins: Are These Non-Classical Neuropeptides?

(2010) Julia S. Gelman et al.   AAPS Journal

Binding of the Hemopressin Peptide to the Cannabinoid CB1Receptor: Structural Insights

(2010) Mario Scrima et al.   BIOCHEMISTRY

Development of selective inhibitors of necrosis

(2010) Mikiko Sodeoka et al.   CHEMICAL RECORD

Plectin-1 as a Novel Biomarker for Pancreatic Cancer

(2010) D. Bausch et al.   CLINICAL CANCER RESEARCH

CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice

(2010) Iryna Berezniuk et al.   FASEB JOURNAL

Hemopressins and other hemoglobin-derived peptides in mouse brain: comparison between brain, blood, and heart peptidome and regulation inCpefat/fatmice

(2010) Julia S. Gelman et al.   JOURNAL OF NEUROCHEMISTRY

The Peptide Hemopressin Acts through CB1 Cannabinoid Receptors to Reduce Food Intake in Rats and Mice

(2010) G. T. Dodd et al.   JOURNAL OF NEUROSCIENCE

Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins

(2010) Lloyd D. Fricker   Molecular BioSystems

Novel endogenous peptide agonists of cannabinoid receptors

(2009) Ivone Gomes et al.   FASEB JOURNAL

Analysis of Intracellular Substrates and Products of Thimet Oligopeptidase in Human Embryonic Kidney 293 Cells

(2009) Denise A. Berti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plectin-1 is a Biomarker of Malignant Pancreatic Intraductal Papillary Mucinous Neoplasms

(2009) Dirk Bausch et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

(2009) N. A. Jones et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Intracellular Peptides as Natural Regulators of Cell Signaling

(2008) Fernanda M. Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition

(2007) Jacqueline M. Burrows et al.   MOLECULAR IMMUNOLOGY