The Contribution of the 20S Proteasome to Proteostasis

Functional regulation of proteins by 20S proteasome proteolytic processing

(2018) Maya A. Olshina et al.   CELL CYCLE

The multiple functions and mechanisms of osteopontin

(2018) Mehmet Arif Icer et al.   CLINICAL BIOCHEMISTRY

Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift

(2018) Jane A. Armstrong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome

(2018) Kapil V. Ramachandran et al.   MOLECULAR CELL

Maintaining a Healthy Proteome during Oxidative Stress

(2018) Dana Reichmann et al.   MOLECULAR CELL

Next-generation proteasome inhibitors for cancer therapy

(2018) Ji Eun Park et al.   Translational Research

The Disordered Landscape of the 20S Proteasome Substrates Reveals Tight Association with Phase Separated Granules

(2018) Nadav Myers et al.   PROTEOMICS

Evidences against vesicle-dependent trafficking and involvement of extracellular proteasomes into cell-to-cell communications

(2018) Egor E. Diakonov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

(2017) Xiaorong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of declining adaptive homeostasis in ageing

(2017) Laura C. D. Pomatto et al.   JOURNAL OF PHYSIOLOGY-LONDON

Circulating proteasomes: circling myeloma with a new potential biomarker

(2017) Tanya M. Spektor et al.   LEUKEMIA & LYMPHOMA

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exosomes as Reconfigurable Therapeutic Systems

(2017) R. Steven Conlan et al.   TRENDS IN MOLECULAR MEDICINE

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

(2017) Kapil V Ramachandran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomic analysis of affinity-purified extracellular proteasomes reveals exclusively 20S complexes

(2017) Valentina A. Kulichkova et al.   Oncotarget

Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis

(2017) Chiara Dianzani et al.   Scientific Reports

The Proteasome Inhibition Model of Parkinson’s Disease

(2017) Eduard Bentea et al.   Journal of Parkinsons Disease

The Proteasome and Oxidative Stress in Alzheimer's Disease

(2016) Vicent Bonet-Costa et al.   ANTIOXIDANTS & REDOX SIGNALING

Mammalian proteasome subtypes: Their diversity in structure and function

(2016) Burkhardt Dahlmann   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome

(2016) Sandra Reeg et al.   FREE RADICAL BIOLOGY AND MEDICINE

KIAA0368-deficiency affects disassembly of 26S proteasome under oxidative stress condition

(2016) Kousuke Haratake et al.   JOURNAL OF BIOCHEMISTRY

Extracellular Proteasomes Are Deficient in 19S Subunits as Revealed by iTRAQ Quantitative Proteomics

(2016) Anna S. Tsimokha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress inC. elegans

(2016) Rachel Raynes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Enzymatic activities of circulating plasma proteasomes in newly diagnosed multiple myeloma patients treated with carfilzomib, lenalidomide and dexamethasone

(2016) Elisabet E. Manasanch et al.   LEUKEMIA & LYMPHOMA

Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways

(2016) Rachel Raynes et al.   MOLECULAR ASPECTS OF MEDICINE

OUP accepted manuscript

(2016)   NUCLEIC ACIDS RESEARCH

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

(2016) Juliane Liepe et al.   SCIENCE

Protein Quality Control under Oxidative Stress Conditions

(2015) Jan-Ulrik Dahl et al.   JOURNAL OF MOLECULAR BIOLOGY

Deciphering preferential interactions within supramolecular protein complexes: the proteasome case

(2015) B. Fabre et al.   Molecular Systems Biology

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The 20 S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

(2015) Mélanie Dieudé et al.   Science Translational Medicine

The Parkinson’s-associated protein DJ-1 regulates the 20S proteasome

(2015) Oren Moscovitz et al.   Nature Communications

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

Circulating 20S Proteasome Is Independently Associated with Abdominal Muscle Mass in Hemodialysis Patients

(2015) Hirotaka Fukasawa et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Regulation of the Proteasome: Evaluating the Lung Proteasome as a New Therapeutic Target

(2014) Silke Meiners et al.   ANTIOXIDANTS & REDOX SIGNALING

Label-Free Quantitative Proteomics Reveals the Dynamics of Proteasome Complexes Composition and Stoichiometry in a Wide Range of Human Cell Lines

(2014) Bertrand Fabre et al.   JOURNAL OF PROTEOME RESEARCH

Polyphosphate Is a Primordial Chaperone

(2014) Michael J. Gray et al.   MOLECULAR CELL

An overview of the progress in the treatment of multiple myeloma

(2014) Robert A Kyle et al.   Expert Review of Hematology

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Assembly of the 20S proteasome

(2013) Mary J. Kunjappu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of proteasome activity in health and disease

(2013) Marion Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes

(2013) Isabel Bochmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells

(2013) Jin-Gu Lee et al.   Nature Communications

Redox Control of 20S Proteasome Gating

(2012) Gustavo M. Silva et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins

(2012) Andrew M. Pickering et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster

(2012) A. M. Pickering et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Redox Control of the Ubiquitin-Proteasome System: From Molecular Mechanisms to Functional Significance

(2011) Franziska Kriegenburg et al.   ANTIOXIDANTS & REDOX SIGNALING

Ubiquitin-independent proteasomal degradation during oncogenic viral infections

(2011) Jiwon Hwang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

(2011) Tilman Grune et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress-Mediated Regulation of Proteasome Complexes

(2011) Charity T. Aiken et al.   MOLECULAR & CELLULAR PROTEOMICS

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

(2011) Fanjun Meng et al.   Molecular Neurodegeneration

Effects of Oxidative Stress on Behavior, Physiology, and the Redox Thiol Proteome of Caenorhabditis elegans

(2010) Caroline Kumsta et al.   ANTIOXIDANTS & REDOX SIGNALING

Processing of autophagic protein LC3 by the 20S proteasome

(2010) Zhonghua Gao et al.   Autophagy

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

The prognostic impact of circulating proteasome concentrations in patients with epithelial ovarian cancer

(2010) Martin Heubner et al.   GYNECOLOGIC ONCOLOGY

Circulating Proteasomes After Burn Injury

(2010) Matthias Majetschak et al.   Journal of Burn Care & Research

Splicing of Distant Peptide Fragments Occurs in the Proteasome by Transpeptidation and Produces the Spliced Antigenic Peptide Derived from Fibroblast Growth Factor-5

(2010) A. Dalet et al.   JOURNAL OF IMMUNOLOGY

Regulation of the 26S Proteasome Complex During Oxidative Stress

(2010) X. Wang et al.   Science Signaling

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Proteasome Enzymatic Activities in Plasma as Risk Stratification of Patients with Acute Myeloid Leukemia and Advanced-Stage Myelodysplastic Syndrome

(2009) W. Ma et al.   CLINICAL CANCER RESEARCH

Proteasomes Can Degrade a Significant Proportion of Cellular Proteins Independent of Ubiquitination

(2009) James M. Baugh et al.   JOURNAL OF MOLECULAR BIOLOGY

Exosomal Secretion of Cytoplasmic Prostate Cancer Xenograft-derived Proteins

(2009) Flip H. Jansen et al.   MOLECULAR & CELLULAR PROTEOMICS

Extracellular, circulating proteasomes and ubiquitin — Incidence and relevance

(2008) Stephan U. Sixt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Circulating 20S Proteasome Levels in Patients with Mixed Connective Tissue Disease and Systemic Lupus Erythematosus

(2008) M. Majetschak et al.   Clinical and Vaccine Immunology

26S proteasome regulatory particle mutants have increased oxidative stress tolerance

(2007) Jasmina Kurepa et al.   PLANT JOURNAL