Regulated Necrotic Cell Death in Alternative Tumor Therapeutic Strategies

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

(2020) Ye Yang et al.   BMC CANCER

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells

(2020) Rongjun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis

(2020) Perawatt Akara-amornthum et al.   PLoS One

lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer

(2020) Qingzhu Yang et al.   Molecular Therapy-Nucleic Acids

Potential Applications of NRF2 Modulators in Cancer Therapy

(2020) Emiliano Panieri et al.   Antioxidants

BIX‐01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME‐mediated pyroptosis

(2020) Bei‐Bei Deng et al.   CELL BIOLOGY INTERNATIONAL

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

(2020) Lei Hu et al.   Cell Death & Disease

Role of GSDMB in Pyroptosis and Cancer

(2020) Lisha Li et al.   Cancer Management and Research

SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis

(2020) Rui Guo et al.   GENE

Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo

(2020) Tao Song et al.   INVESTIGATIONAL NEW DRUGS

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Ferroptosis in Cancer Treatment: Another Way to Rome

(2020) Yinan Wu et al.   Frontiers in Oncology

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

(2020) Minlin Jiang et al.   Translational Lung Cancer Research

Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4‑mediated ferroptosis

(2019) Xiaofen Pan et al.   Oncology Letters

Pyroptosis in combinatorial treatment to improve cancer patients' outcome, is that what we want?

(2019) Julia Alejandra Pezuk   EBioMedicine

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

(2019) Ilana Chefetz et al.   Cell Reports

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

The Induction of Ferroptosis by Impairing STAT3/Nrf2/GPx4 Signaling Enhances the Sensitivity of Osteosarcoma Cells to Cisplatin

(2019) Qiang Liu et al.   CELL BIOLOGY INTERNATIONAL

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

(2019) Lu Wang et al.   CANCER LETTERS

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

(2019) Fabrice Collin   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

(2019) Philip A. Harris et al.   ACS Medicinal Chemistry Letters

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

(2019) Yves Dondelinger et al.   Nature Communications

Immunogenic cell death in cancer therapy: Present and emerging inducers

(2019) Jingyi Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

(2019) Annelise G. Snyder et al.   Science Immunology

Cancer Prevention with Nutrition and Lifestyle

(2019) Eva Kerschbaum et al.   Visceral Medicine

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

High SLC7A11 expression in normal skin of melanoma patients

(2019) Ismael Galván et al.   Cancer Epidemiology

Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis

(2019) Masataka Someda et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

(2019) Yiwei Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma

(2019) Jie Wei et al.   Molecular Medicine Reports

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Erastin/sorafenib induces cisplatin‑resistant non‑small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway

(2019) Yu Li et al.   Oncology Letters

Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells

(2019) Yu-Shih Lin et al.   Frontiers in Pharmacology

Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo

(2019) Yuki Shibata et al.   PLoS One

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

(2019) Yunseo Woo et al.   Journal of Oncology

Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe

(2018) Masato Niwa et al.   ACS Chemical Biology

Prognostic and clinicopathological significance of MLKL expression in cancer patients: a meta-analysis

(2018) Binwu Hu et al.   BMC CANCER

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma

(2018) Liang Zhang et al.   Future Oncology

Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

(2018) Fengjiao Wang et al.   International Journal of Biological Sciences

Apoptosis: A Target for Anticancer Therapy

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunogenic Apoptosis as a Novel Tool for Anticancer Vaccine Development

(2018) Barbara Montico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

(2018) Shouya Feng et al.   JOURNAL OF MOLECULAR BIOLOGY

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis

(2018) Qinrui Han et al.   Journal of Translational Medicine

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

(2018) Natascha A. Wolff  et al.   Scientific Reports

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer

(2018) Jianwei Gao et al.   ONCOLOGY REPORTS

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

(2018) Xianbo Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tissue necrosis and its role in cancer progression

(2018) Adi Karsch-Bluman et al.   ONCOGENE

Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma

(2018) Lei Shen et al.   World Journal of Surgical Oncology

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

(2018) Iva Hafner-Bratkovič et al.   Nature Communications

HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer

(2018) Jung Hee Park et al.   CANCER LETTERS

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death

(2017) Naoshad Muhammad et al.   Oncotarget

Near-infrared photothermal therapy using anti-EGFR-gold nanorod conjugates for triple negative breast cancer

(2017) Meihua Zhang et al.   Oncotarget

The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma

(2017) Jeong Hyun Cho et al.   Oncotarget

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

(2017) Uris Ros et al.   Cell Reports

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

(2017) Giulia Fianco et al.   eLife

Gasdermin: A new player to the inflammasome game

(2017) Erivan S. Ramos-Junior et al.   Biomedical Journal

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome

(2016) Kenta Moriwaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

(2016) Deli Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma

(2016) JIAN GAO et al.   ONCOLOGY REPORTS

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

(2016) Xinlei Yu et al.   Scientific Reports

Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis

(2015) Stephan Philipp et al.   Cell Communication and Signaling

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

Regulated Necrotic Cell Death: The Passive Aggressive Side of Bax and Bak

(2015) J. Karch et al.   CIRCULATION RESEARCH

Inhibiting the inflammasome: one domain at a time

(2015) Andrea Dorfleutner et al.   IMMUNOLOGICAL REVIEWS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB

(2015) M Oliver Metzig et al.   ONCOGENE

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

(2015) Stephanie M. Robert et al.   Science Translational Medicine

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

(2015) P Geserick et al.   Cell Death & Disease

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

(2015) K Moriwaki et al.   Cell Death & Disease

A single cut to pyroptosis

(2015) Yoon Lim et al.   Oncotarget

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

Effect of autophagy inhibition on cell viability and cell cycle progression in MDA-MB-231 human breast cancer cells

(2014) QIUJUN LIU et al.   Molecular Medicine Reports

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

(2014) Asima Bhattacharyya et al.   PHYSIOLOGICAL REVIEWS

A Plug Release Mechanism for Membrane Permeation by MLKL

(2014) Lijing Su et al.   STRUCTURE

Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells

(2014) Betty Yuen Kwan Law et al.   Scientific Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

(2013) Zeze Fu et al.   BMC CANCER

RIP1 potentiates BPDE-induced transformation in human bronchial epithelial cells through catalase-mediated suppression of excessive reactive oxygen species

(2013) Qiong Wang et al.   CARCINOGENESIS

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy

(2013) M. Selvakumaran et al.   CLINICAL CANCER RESEARCH

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

(2013) Susannah D. Brydges et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferons as Inducers of Apoptosis in Malignant Cells

(2013) Kevin P. Kotredes et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Cell Death–Stimulated Cell Proliferation: A Tissue Regeneration Mechanism Usurped by Tumors During Radiotherapy

(2013) Mary A. Zimmerman et al.   SEMINARS IN RADIATION ONCOLOGY

Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients

(2013) Fu-fan Zhu et al.   OncoTargets and Therapy

Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells

(2013) V KW Wong et al.   Cell Death & Disease

Regulation of cell death in cancer—possible implications for immunotherapy

(2013) Simone Fulda   Frontiers in Oncology

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Programmed necrosis and autophagy in immune function

(2012) Jennifer V. Lu et al.   IMMUNOLOGICAL REVIEWS

Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells

(2012) Zsuzsanna A. Dunai et al.   PLoS One

A short-term biomarker modulation study of simvastatin in women at increased risk of a new breast cancer

(2011) Michaela J. Higgins et al.   BREAST CANCER RESEARCH AND TREATMENT

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2

(2011) Kerstin Brecht et al.   FASEB JOURNAL

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers

(2011) Matthew A. Nehs et al.   SURGERY

Assessment of the Evolution of Cancer Treatment Therapies

(2011) Manuel Arruebo et al.   Cancers

Inflammation: A driving force speeds cancer metastasis

(2010) Yadi Wu et al.   CELL CYCLE

Stimulation of the endosomal TLR pathway enhances autophagy-induced cell death in radiotherapy of breast cancer

(2010) Su-Jin Kang et al.   Genes & Genomics

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

(2010) L Liu et al.   LEUKEMIA

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

(2009) Donglei Liu et al.   MEDICAL ONCOLOGY

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3

(2008) Kenneth Ndebele et al.   APOPTOSIS

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4

(2008) M Todaro et al.   CELL DEATH AND DIFFERENTIATION

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

(2007) Kirsteen H. Maclean et al.   JOURNAL OF CLINICAL INVESTIGATION