CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

(2020) Isabel R Schlaepfer et al.   ENDOCRINOLOGY

Lipid droplet‐mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib

(2020) Bernhard Englinger et al.   INTERNATIONAL JOURNAL OF CANCER

Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity

(2020) Shashank Shrishrimal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Fatty Acid Oxidation to Promote Anoikis and Inhibit Ovarian Cancer Progression

(2020) Brandon T. Sawyer et al.   MOLECULAR CANCER RESEARCH

Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K

(2019) Hanan B. Elajaili et al.   Jove-Journal of Visualized Experiments

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

(2019) Miguel Reina-Campos et al.   CANCER CELL

Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer

(2019) Xia Gao et al.   CANCER CELL

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis

(2019) Eduardo Balsa et al.   MOLECULAR CELL

Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

(2019) Yi‐Hsiang Wang et al.   EMBO REPORTS

CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions

(2019) Joshi et al.   Cells

Sex Hormones and Prostate Cancer

(2019) Richard J. Auchus et al.   Annual Review of Medicine

Clinical features of neuroendocrine prostate cancer

(2019) Vincenza Conteduca et al.   EUROPEAN JOURNAL OF CANCER

Recent Advances in Prostate Cancer Treatment and Drug Discovery

(2018) Ekaterina Nevedomskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle

(2018) Anand Kumar Bachhawat et al.   IUBMB LIFE

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

(2018) Xia Gao et al.   Cell Reports

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

(2018) Cong-Hui Yao et al.   PLOS BIOLOGY

Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination

(2018) Kimberley D. Bruce et al.   Frontiers in Molecular Neuroscience

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

(2018) Adam Sharp et al.   JOURNAL OF CLINICAL INVESTIGATION

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

(2017) Martina Schweiger et al.   Nature Communications

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

(2017) Meng-Shian Chen et al.   Oncotarget

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

(2017) Thomas W. Flaig et al.   Oncotarget

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

(2016) Himisha Beltran et al.   NATURE MEDICINE

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

(2015) Rebecca R. Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake in Prostate Cancer Mouse Xenografts

(2015) Isabel R. Schlaepfer et al.   MOLECULAR IMAGING AND BIOLOGY

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

(2015) Isabel R. Schlaepfer et al.   Oncotarget

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

(2012) Akhilesh Kumar et al.   EMBO REPORTS

Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel

(2012) Isabel R. Schlaepfer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Prostate Cancer, Androgen Deprivation Therapy, Obesity, the Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

(2011) Andrew Collier et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients

(2011) G Goebel et al.   BRITISH JOURNAL OF CANCER

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features

(2011) V. Tzelepi et al.   CLINICAL CANCER RESEARCH

Alternatively spliced androgen receptor variants

(2011) Scott M Dehm et al.   ENDOCRINE-RELATED CANCER

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

(2011) Jianguo Xia et al.   Nature Protocols

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

(2011) S. K. Das et al.   SCIENCE

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

(2008) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA