Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

(2014) I. N. Mungrue et al.   JOURNAL OF IMMUNOLOGY

RNA Sequence Reveals Mouse Retinal Transcriptome Changes Early after Axonal Injury

(2014) Masayuki Yasuda et al.   PLoS One

Botch Is a γ-Glutamyl Cyclotransferase that Deglycinates and Antagonizes Notch

(2014) Zhikai Chi et al.   Cell Reports

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

(2014) Satoshi Tsunoda et al.   eLife

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis

(2013) Linn-Karina M Selvik et al.   BMC GENOMICS

ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice

(2013) Guozhi Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional and post-translational regulation of mouse cation transport regulator homolog 1

(2013) Kentaro Oh-hashi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Transcriptome Analysis of Genes Regulated by Cholesterol Loading in Two Strains of Mouse Macrophages Associates Lysosome Pathway and ER Stress Response with Atherosclerosis Susceptibility

(2013) Stela Z. Berisha et al.   PLoS One

Transcriptome Analysis of Duck Liver and Identification of Differentially Expressed Transcripts in Response to Duck Hepatitis A Virus Genotype C Infection

(2013) Cheng Tang et al.   PLoS One

Botch Promotes Neurogenesis by Antagonizing Notch

(2012) Zhikai Chi et al.   DEVELOPMENTAL CELL

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

(2012) Akhilesh Kumar et al.   EMBO REPORTS

ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation

(2012) Jixiu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response

(2012) Lingchen Fu et al.   PHYSIOLOGICAL GENOMICS

Induction of Endoplasmic Reticulum Stress Response by the Indole-3-Carbinol Cyclic Tetrameric Derivative CTet in Human Breast Cancer Cell Lines

(2012) Luca Galluzzi et al.   PLoS One

Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1

(2012) Nam E. Joo et al.   Cancer Medicine

Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients

(2011) G Goebel et al.   BRITISH JOURNAL OF CANCER

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids

(2011) Casey E. Romanoski et al.   CIRCULATION RESEARCH

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells

(2010) Casey E. Romanoski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes

(2010) Laurent Magne et al.   JOURNAL OF HEPATOLOGY

Changes to Euchromatin on LAT and ICP4 Following Reactivation Are More Prevalent in an Efficiently Reactivating Strain of HSV-1

(2010) Clinton C. Creech et al.   PLoS One

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

(2009) Tatsuya Yoshizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Differential Control of the CCAAT/Enhancer-binding Protein β (C/EBPβ) Products Liver-enriched Transcriptional Activating Protein (LAP) and Liver-enriched Transcriptional Inhibitory Protein (LIP) and the Regulation of Gene Expression during the Response to Endoplasmic Reticulum Stress

(2008) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene

(2008) Nan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Avian influenza virus infection induces differential expression of genes in chicken kidney

(2007) Wanpo Zhang et al.   RESEARCH IN VETERINARY SCIENCE