Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade

(2016) Zhengle Zhang et al.   CANCER LETTERS

Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells

(2016) Bal Krishan Sharma et al.   FASEB JOURNAL

Cancer stem cells, metabolism, and therapeutic significance

(2016) Mengqi Yang et al.   TUMOR BIOLOGY

Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine

(2016) Tao Yin et al.   Oncotarget

Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis

(2016) Hiromitsu Ito et al.   PLoS One

ROS and energy metabolism in cancer cells: alliance for fast growth

(2015) Sang Won Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Metabolic control of cancer cell stemness: Lessons from iPS cells

(2015) Javier A Menendez   CELL CYCLE

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma

(2015) Nathaniel Weygant et al.   Oncotarget

Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism

(2015) Shuqiang Yuan et al.   Stem Cell Research & Therapy

New insights into pancreatic cancer stem cells

(2015) Chinthalapally V Rao   World Journal of Stem Cells

Metabolic Regulation of Redox Status in Stem Cells

(2014) Ester Perales-Clemente et al.   ANTIOXIDANTS & REDOX SIGNALING

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

(2014) Yao-An Shen et al.   CELL CYCLE

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype

(2013) Michael S. Schieber et al.   CANCER CELL

Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model

(2013) Jingjia Ye et al.   CANCER SCIENCE

DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

(2013) Jennifer M. Bailey et al.   GASTROENTEROLOGY

Identification of a Novel Subpopulation of Tumor-Initiating Cells from Gemcitabine-Resistant Pancreatic Ductal Adenocarcinoma Patients

(2013) Kazuya Shimizu et al.   PLoS One

Energy metabolism plasticity enables stemness programs

(2012) Clifford D.L. Folmes et al.   Annals of the New York Academy of Sciences

Pancreatic cancer stem cells: Emerging target for designing novel therapy

(2012) Yiwei Li et al.   CANCER LETTERS

Pancreatic cancer cells surviving gemcitabine treatment express markers of stem cell differentiation and epithelial-mesenchymal transition

(2012) KARL QUINT et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

DCAMKL-1 Regulates Epithelial-Mesenchymal Transition in Human Pancreatic Cells through a miR-200a-Dependent Mechanism

(2011) S. M. Sureban et al.   CANCER RESEARCH

Regulation of reactive oxygen species in stem cells and cancer stem cells

(2011) Chiharu I. Kobayashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in “Stem-Cell-Like” Tumor Cells

(2010) Zhiyong Du et al.   DIGESTIVE DISEASES AND SCIENCES

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

(2009) Z. Wang et al.   CANCER RESEARCH

Cancer Stem Cells: A New Paradigm for Understanding Tumor Growth and Progression and Drug Resistance

(2009) Rosaria Gangemi et al.   CURRENT MEDICINAL CHEMISTRY

Glucose deprivation-induced metabolic oxidative stress and cancer therapy

(2009) DouglasR Spitz et al.   Journal of Cancer Research and Therapeutics

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

(2008) Kazuhito Naka et al.   ANTIOXIDANTS & REDOX SIGNALING

2-Deoxy-d-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer

(2007) Mitchell C. Coleman et al.   FREE RADICAL BIOLOGY AND MEDICINE