Article
Oncology
Zhiwei He, Jie Wang, Changhao Zhu, Jian Xu, Peng Chen, Xueyi Jiang, Yankun Chen, Jianxin Jiang, Chengyi Sun
Summary: In this study, it was found that PC cells generate exosomes rich in FGD5-AS1, which promote M2 macrophage polarization and malignant behaviors of PC cells. FGD5-AS1 activates the STAT3/ NF-Kappa B pathway and interacts with p300, leading to STAT3 acetylation and nuclear localization. These findings highlight the important role of exosomal FGD5-AS1 in PC.
Article
Oncology
Ming Xiao, Qi Bian, Yimin Lao, Jing Yi, Xueqing Sun, Xuxu Sun, Jie Yang
Summary: Deletion of SUMO-specific protease 3 in macrophages promotes polarization towards the M2 subtype and accelerates breast cancer malignancy. The deficiency of SENP3 leads to increased SUMOylation of Akt1, resulting in hyper-phosphorylation and activation of Akt1, thus facilitating M2 polarization and tumor progression.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Min Yao, Xuhua Mao, Zherui Zhang, Yue Xi, Haining Gan, Feilun Cui, Shihe Shao
Summary: CircRNA_102191 promotes the progression of gastric cancer cells by regulating the miR-493-3p/XPR1 axis and M2 macrophage polarization.
Article
Pharmacology & Pharmacy
Heng Yang, Wanqi Lan, Wu Liu, Tingtao Chen, Yanhua Tang
Summary: Our study demonstrates that dapagliflozin significantly accelerates blood flow recovery and reduces limb necrosis in a mouse model of hindlimb ischemia. This effect is mediated through enhanced angiogenesis, reduced muscle fibrosis, and induction of macrophage phenotypic shift from M1 to M2 and decreased expression of inflammatory factors. Dapagliflozin may exert these effects partially through modulation of the NF-κB signaling pathway. Furthermore, dapagliflozin enhances endothelial cell proliferation, migration, and tube formation in vitro.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Renqiang Sun, Zhiyong Zhang, Ruoxuan Bao, Xiaozhen Guo, Yuan Gu, Wenjing Yang, Jinsong Wei, Xinyu Chen, Lingfeng Tong, Jian Meng, Chen Zhong, Cheng Zhang, Jinye Zhang, Yiping Sun, Chen Ling, Xuemei Tong, Fa-Xing Yu, Hongxiu Yu, Weifeng Qu, Bing Zhao, Wei Guo, Maoxiang Qian, Hexige Saiyin, Ying Liu, Rong-Hua Liu, Cen Xie, Weiren Liu, Yue Xiong, Kun-Liang Guan, Yinghong Shi, Pu Wang, Dan Ye
Summary: This study uncovers a new function of SIRT5 in regulating bile acid metabolism to prevent tumor immune evasion and suppress HCC development.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Yang Ge, Xiaona Fan, Xuying Huang, Nathaniel Weygant, Zeru Xiao, Rui Yan, Heshu Liu, Jian Liu, Guangyu An, Jiannan Yao
Summary: DCLK1-S expression is significantly increased in human esophageal squamous cell carcinoma (ESCC) tissues and is associated with malignant progression and poor prognosis. Functional studies showed that DCLK1-S plays a role in promoting ESCC cell proliferation, migration, and invasion, potentially through the MAPK/ERK/MMP2 pathway. These findings suggest that DCLK1-S may serve as a biomarker or therapeutic target for improving outcomes in patients with ESCC.
MOLECULAR CANCER RESEARCH
(2021)
Article
Microbiology
Xinyue Wang, Bin Yang, Shuangshuang Ma, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang
Summary: Lactate promotes Salmonella intracellular replication and systemic infection by driving macrophage M2 polarization.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Cell Biology
Chunjuan Yang, Biao Ni, Chaoran Li, Wenchang Sun, Zhangxue Wang, Hui Wang, Xinyue Hou, Shushan Yan, Xiaodong Wang, Donghua Xu
Summary: Accumulating studies have shown that circRNAs play crucial roles in the development of RA. However, the effects and mechanisms of circRNAs on macrophage polarization and immune homeostatic balance in RA are not well understood. This study aimed to investigate the role of circRNA_17725 in RA.
MEDIATORS OF INFLAMMATION
(2023)
Article
Immunology
Minni Zhang, Kun Liu, Qiuyue Zhang, Junnv Xu, Jinchen Liu, Haifeng Lin, Bo Lin, Mingyue Zhu, Mengsen Li
Summary: The role of AFP in regulating macrophage function and phagocytosis is still unclear. This study explored the correlation between AFP regulation of macrophages and the possible regulatory mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yujiao Zhang, Yizeng Fan, Xin Jing, Lin Zhao, Tianjie Liu, Lu Wang, Lifen Zhang, Shanzhi Gu, Xinhan Zhao, Yan Teng
Summary: Studies have shown that the activation of YAP increases macrophage recruitment, but its role in macrophage polarization, especially in TNBC progression, is still unclear. TNBC cells were found to increase YAP expression in macrophages via OTUD5-mediated deubiquitination and stabilization, leading to polarization towards the M2-like phenotype. Additionally, high expression of YAP in M2-like macrophages was associated with pro-metastatic potential of TNBC cells through the MCP-1/CCR2 pathway, and negatively related to survival. This suggests that targeting YAP(+) M2 macrophages could be a novel therapeutic strategy for TNBC treatment.
Article
Immunology
Tao Liu, Liqiu Wang, Puping Liang, Xiaojuan Wang, Yukun Liu, Jing Cai, Yuanchu She, Dan Wang, Zhi Wang, Zhiyong Guo, Samuel Bates, Xiaojun Xia, Junjiu Huang, Jun Cui
Summary: The study reveals that USP19 acts as an anti-inflammatory switch promoting M2-like macrophage polarization and inhibiting inflammatory responses by affecting NLRP3 activity through various mechanisms.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jinling Zhang, Fangyue Cheng, Genxiang Rong, Zhi Tang, Binjie Gui
Summary: The study revealed that overexpression of hsa_circ_0005567 promoted M2 macrophage polarization through the miR-492/SOCS2 axis, reducing chondrocyte apoptosis and inhibiting the progression of osteoarthritis.
Article
Biochemistry & Molecular Biology
Jung Bae Seong, Bokyung Kim, Soyoon Kim, Mi Hye Kim, Young-Ho Park, Youngjeon Lee, Hong Jun Lee, Chang-Won Hong, Dong-Seok Lee
Summary: This study revealed that deficiency of the antioxidant enzyme peroxiredoxin 5 (Prx5) in macrophages induced M2 macrophage polarization, promoting lung cancer progression. However, suppression of ROS generation by N-acetyl cysteine (NAC) inhibited the M2-like polarization of Prx5-deficient macrophages, leading to inhibition of lung cancer cell proliferation and migration, and suppression of tumor growth. These findings suggest that blocking the M2 polarization of macrophages may promote lung cancer regression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yaowei Xuan, Lin Li, Muzhi Ma, Junkai Cao, Zhen Zhang
Summary: Mineralized collagen is a promising barrier membrane material for guided bone regeneration (GBR). In this study, hierarchical intrafibrillarly mineralized collagen (HIMC) membrane was fabricated, which showed preferable physicochemical properties and promoted cell adhesion, proliferation, and osteogenic differentiation. HIMC membrane also induced macrophage polarization and enhanced bone regeneration. Therefore, HIMC membrane represents a promising material for GBR.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Zeyu Wang, Guanhua Su, Ziyu Dai, Ming Meng, Hao Zhang, Fan Fan, Zhengzheng Liu, Longbo Zhang, Nathaniel Weygant, Fengqiong He, Ning Fang, Liyang Zhang, Quan Cheng
Summary: Circadian clock gene expression in glioma is associated with disease progression, affecting the tumor immune landscape and cell cycle, potentially impacting survival outcomes. A risk model can predict glioma survival outcomes and may be applicable to other types of cancer.
CELL PROLIFERATION
(2021)
Article
Gastroenterology & Hepatology
Allyson J. Merrell, Tao Peng, Jinyang Li, Kathryn Sun, Bin Li, Takeshi Katsuda, Markus Grompe, Kai Tan, Ben Z. Stanger
Summary: Hepatocytes undergo extensive chromatin and transcriptional changes during biliary reprogramming, resulting in altered gene expression profiles including robust induction of biliary genes and weaker repression of hepatocyte genes. Single-cell analysis revealed that Smad4 mutation can significantly increase reprogramming.
Article
Gastroenterology & Hepatology
Nathaniel Weygant, Karen Chang, Christian S. Jackson, Kenneth J. Vega
Summary: This study used the TCGA EC dataset to analyze whether survival rates vary by sex in esophageal cancer patients, finding that male patients have lower survival rates, and some genetic alterations are dysregulated in patients of different sexes.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Oncology
Liyang Zhang, Fangkun Liu, Nathaniel Weygant, Junxia Zhang, Ping Hu, Zailong Qin, Jingxuan Yang, Quan Cheng, Fan Fan, Yu Zeng, Yongjian Tang, Yusheng Li, Anliu Tang, Fengqiong He, Jun Peng, Weihua Liao, Zhongliang Hu, Min Li, Zhixiong Liu
Summary: Researchers developed an integrated system using patient-derived glioma cerebral organoids and xenograft models to understand glioma biology and predict response to chemotherapy drugs, providing a new strategy for personalized treatment of this deadly disease.
Article
Oncology
Chinthalapally V. Rao, Chao Xu, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Summary: Genomic instability plays a crucial role in the evolution and treatment of lung adenocarcinoma, with genes associated with survival potentially serving as future therapeutic targets. The immune system has been identified as a key player in suppressing genomic instability and cancer development in the lungs, suggesting potential avenues for chemotherapy, chemoprevention, and immunomodulation approaches.
Review
Oncology
Ling Ding, Yuning Yang, Qin Lu, Zhiyun Cao, Nathaniel Weygant
Summary: This review summarizes the application of human colorectal cancer patient-derived organoids (PDOs) in the study of cancer stem cells (CSCs) and the cancer stem cell niche. It focuses on the relevance of PDOs in understanding CSC-related signaling, interactions between CSCs and the tumor microenvironment, and the modeling of CSC-driven resistance to therapies.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Oncology
Yang Ge, Xiaona Fan, Xuying Huang, Nathaniel Weygant, Zeru Xiao, Rui Yan, Heshu Liu, Jian Liu, Guangyu An, Jiannan Yao
Summary: DCLK1-S expression is significantly increased in human esophageal squamous cell carcinoma (ESCC) tissues and is associated with malignant progression and poor prognosis. Functional studies showed that DCLK1-S plays a role in promoting ESCC cell proliferation, migration, and invasion, potentially through the MAPK/ERK/MMP2 pathway. These findings suggest that DCLK1-S may serve as a biomarker or therapeutic target for improving outcomes in patients with ESCC.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Ling Ding, Yuning Yang, Yang Ge, Qin Lu, Zixing Yan, Xuzheng Chen, Jian Du, Sassan Hafizi, Xiaohui Xu, Jiannan Yao, Jian Liu, Zhiyun Cao, Nathaniel Weygant
Summary: This study demonstrates that the small molecule kinase inhibitor DCLK1-IN-1 effectively inhibits DCLK1 phosphorylation and stemness related properties of RCC cells, showing potential as an immunotherapy agent and in combination therapy with anti-PD1. Clinical analysis suggests that DCLK1 predicts RCC survival and its expression is correlated with immune cell infiltration and immunosuppressive macrophage populations.
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Article
Multidisciplinary Sciences
Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, Eric J. Brown, Ben Z. Stanger, Joshua D. Rabinowitz, Xiaolu Yang
Summary: Metastasizing cancer cells can withstand oxidative stress by expanding their NADPH and NADP(+) pools. This expansion is achieved through up-regulation of G6PD and activation of the NADK1 pathway. The transcription factor TAp73 plays a role in activating G6PD, which is regulated by multiple pathways. Elevated levels of G6PD and its activators are found in metastatic pancreatic cancer.
Article
Gastroenterology & Hepatology
Takeshi Katsuda, Hector Cure, Jonathan Sussman, Kamen P. Simeonov, Christopher Krapp, Zoltan Arany, Markus Grompe, Ben Z. Stanger
Summary: This study introduces a rapid in vivo multiplexed editing (RIME) method that enables the efficient inactivation of one or more genes in the mouse liver. The method is quick, efficient, and cost-effective, making it a valuable tool for analyzing multiple genes in vivo.
Article
Biochemistry & Molecular Biology
Ling Ding, Yuning Yang, Qin Lu, Dongfeng Qu, Parthasarathy Chandrakesan, Hailan Feng, Hong Chen, Xuzheng Chen, Zhuhui Liao, Jian Du, Zhiyun Cao, Nathaniel Weygant
Summary: This study investigates the function and mechanism of bufalin against colorectal cancer stemness. The results demonstrate that bufalin inhibits CRC stemness by targeting the C-Kit/Slug signaling axis, leading to inhibited CRC growth and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Venkateshwar Madka, Jagan M. R. Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Chinthalapally V. Rao
Summary: Colon cancer is a significant health problem that is increasing in occurrence, especially among young adults. Previous studies have shown promising preventive effects of drugs like Sulindac and DFMO, but long-term use at high doses can cause side effects. This study explores alternative strategies for preventing colon cancer using low-dose combinations of these drugs, as well as testing the efficacy of Sulindac derivatives. The results suggest that these treatment regimens can effectively inhibit tumor progression without causing toxicity, making them a promising approach for colon cancer prevention.
Article
Medicine, General & Internal
Ling Zhang, Qiaoyan Cai, Shan Lin, Bin Chen, Beibei Jia, Renzhi Ye, Nathaniel Weygant, Jianfeng Chu, Jun Peng
Summary: The study demonstrates that Qingda granule has a significant neuroprotective effect on ischemic stroke, improving neurobehavioral deficits, reducing neuron loss, and inhibiting apoptosis. Furthermore, Qingda granule acts through modulating the lncRNA GAS5/miR-137 signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)