Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

Evolutionary history, potential intermediate animal host, and cross‐species analyses of SARS‐CoV‐2

(2020) Xingguang Li et al.   JOURNAL OF MEDICAL VIROLOGY

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

(2020) Lirong Zou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China

(2020) Zhiliang Hu et al.   Science China-Life Sciences

Influenza A viruses are transmitted via the air from the nasal respiratory epithelium of ferrets

(2020) Mathilde Richard et al.   Nature Communications

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Development of SARS-CoV-2 vaccines: should we focus on mucosal immunity?

(2020) Leticia Moreno-Fierros et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Isolation and rapid sharing of the 2019 novel coronavirus ( SARS ‐CoV‐2) from the first patient diagnosed with COVID ‐19 in Australia

(2020) Leon Caly et al.   MEDICAL JOURNAL OF AUSTRALIA

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

(2020) Jianzhong Shi et al.   SCIENCE

Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets

(2020) Su-Jin Park et al.   mBio

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

(2020) Neeltje van Doremalen et al.   NATURE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice

(2019) Eunice E. To et al.   Scientific Reports

Metagenomic Nanopore Sequencing of Influenza Virus Direct from Clinical Respiratory Samples

(2019) Kuiama Lewandowski et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Temporal cytokine and lymphoid responses to an inhaled TLR7 antedrug agonist in the cynomolgus monkey demonstrates potential safety and tolerability of this approach

(2018) John Bell et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Recent clinical trends in Toll-like receptor targeting therapeutics

(2018) Muhammad Ayaz Anwar et al.   MEDICINAL RESEARCH REVIEWS

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Advances in Antiviral Therapies Targeting Toll-like Receptors

(2016) Masaud Shah et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease

(2016) Tracy A. Delaney et al.   JOURNAL OF IMMUNOLOGY

Ferret models of viral pathogenesis

(2015) T. Enkirch et al.   VIROLOGY

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

(2015) Brendon Y. Chua et al.   mBio

Mapping influenza transmission in the ferret model to transmission in humans

(2015) Michael G Buhnerkempe et al.   eLife

Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam2Cys

(2015) Edin Jessica Mifsud et al.   Frontiers in Immunology

Novel drugs targeting Toll-like receptors for antiviral therapy

(2014) Mira C Patel et al.   Future Virology

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

Intranasal Administration of the TLR2 Agonist Pam2Cys Provides Rapid Protection against Influenza in Mice

(2012) Amabel C. L. Tan et al.   MOLECULAR PHARMACEUTICS

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

The current state of H5N1 vaccines and the use of the ferret model for influenza therapeutic and prophylactic development

(2012) Alyson Ann Kelvin et al.   Journal of Infection in Developing Countries

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Targeting of Toll-like receptors: a decade of progress in combating infectious diseases

(2011) Mona Hedayat et al.   LANCET INFECTIOUS DISEASES

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

The Synthetic Bacterial Lipopeptide Pam3CSK4 Modulates Respiratory Syncytial Virus Infection Independent of TLR Activation

(2010) D. Tien Nguyen et al.   PLoS Pathogens

Pathology of Experimental SARS Coronavirus Infection in Cats and Ferrets

(2008) J. M. A. van den Brand et al.   VETERINARY PATHOLOGY