A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family

Genetic variability of T cell responses in Hypersensitivity Pneumonitis identified using the BXD genetic reference panel

(2020) Jin Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Facilitating Complex Trait Analysis via Reduced Complexity Crosses

(2020) Camron D. Bryant et al.   TRENDS IN GENETICS

Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family

(2020) Jose Vladimir Sandoval-Sierra et al.   AGING CELL

Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

(2019) Megan K. Mulligan et al.   Frontiers in Genetics

Identification of Pre-symptomatic Gene Signatures That Predict Resilience to Cognitive Decline in the Genetically Diverse AD-BXD Model

(2019) Sarah M. Neuner et al.   Frontiers in Genetics

A longitudinal big data approach for precision health

(2019) Sophia Miryam Schüssler-Fiorenza Rose et al.   NATURE MEDICINE

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

(2019) Alexandra M Stafford et al.   eLife

Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population

(2019) Maria Elisa Perez-Munoz et al.   PLoS One

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

(2018) Evan Graehl Williams et al.   MOLECULAR & CELLULAR PROTEOMICS

A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor

(2018) Cheryl Reed et al.   Frontiers in Pharmacology

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

(2018) Hao Li et al.   Cell Systems

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

(2018) Pooja Jha et al.   Cell Systems

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

(2018) Pooja Jha et al.   Cell Systems

Systems genetics of sensation seeking

(2018) Price E. Dickson et al.   GENES BRAIN AND BEHAVIOR

A systems genetics resource and analysis of sleep regulation in the mouse

(2018) Shanaz Diessler et al.   PLOS BIOLOGY

Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice

(2018) Megan K. Mulligan et al.   Frontiers in Genetics

Genetic Influences on the Amount of Cell Death in the Neural Tube of BXD Mice Exposed to Acute Ethanol at Mid-Gestation

(2018) Emilie T. Théberge et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

R/qtl2: Software for Mapping Quantitative Trait Loci with High-Dimensional Data and Multi-parent Populations

(2018) Karl W. Broman et al.   GENETICS

Tissue-Specific Trans Regulation of the Mouse Epigenome

(2018) Christopher L. Baker et al.   GENETICS

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine

(2018) Sarah M. Neuner et al.   NEURON

Born to Cry: A Genetic Dissection of Infant Vocalization

(2018) David George Ashbrook et al.   Frontiers in Behavioral Neuroscience

Ethanol’s Effect on Coq7 Expression in the Hippocampus of Mice

(2018) Diana Zhou et al.   Frontiers in Genetics

Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits

(2017) A. T. Knoll et al.   GENES BRAIN AND BEHAVIOR

Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice

(2017) Bárbara de A. Rodrigues et al.   Frontiers in Cellular Neuroscience

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

(2017) Sumana R. Chintalapudi et al.   Nature Communications

High-Resolution Maps of Mouse Reference Populations

(2017) Petr Simecek et al.   G3-Genes Genomes Genetics

Genetic Variation in the Social Environment Contributes to Health and Disease

(2017) Amelie Baud et al.   PLoS Genetics

Divergence in Morris Water Maze-Based Cognitive Performance under Chronic Stress Is Associated with the Hippocampal Whole Transcriptomic Modification in Mice

(2017) Seung H. Jung et al.   Frontiers in Molecular Neuroscience

Gene-by-Diet Interactions Affect Serum 1,25-Dihydroxyvitamin D Levels in Male BXD Recombinant Inbred Mice

(2016) James C. Fleet et al.   ENDOCRINOLOGY

Novel Genetic Loci Control Calcium Absorption and Femur Bone Mass as Well as Their Response to Low Calcium Intake in Male BXD Recombinant Inbred Mice

(2016) Perla C Reyes Fernandez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging

(2016) Sarah M. Neuner et al.   NEUROBIOLOGY OF AGING

Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci – A None-Experimental Solution

(2016) Lishi Wang et al.   PLoS One

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

Joint mouse–human phenome-wide association to test gene function and disease risk

(2016) Xusheng Wang et al.   Nature Communications

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models

(2016) Jae Hoon Sul et al.   PLoS Genetics

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse

(2016) Karthickeyan Chella Krishnan et al.   PLoS Pathogens

The FAIR Guiding Principles for scientific data management and stewardship

(2016) Mark D. Wilkinson et al.   Scientific Data

Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function

(2016) Xiao Shi et al.   PLoS One

Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice

(2015) Lisa M. Russo et al.   BMC GENOMICS

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

(2015) Evan G. Williams et al.   CELL

Informatics resources for the Collaborative Cross and related mouse populations

(2015) Andrew P. Morgan et al.   MAMMALIAN GENOME

Integrative network analysis reveals molecular mechanisms of blood pressure regulation

(2015) T. Huan et al.   Molecular Systems Biology

Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel

(2015) Price E. Dickson et al.   PSYCHOPHARMACOLOGY

A random forest approach to capture genetic effects in the presence of population structure

(2015) Johannes Stephan et al.   Nature Communications

A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder

(2015) David G. Ashbrook et al.   Frontiers in Behavioral Neuroscience

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping

(2015) Christoph D. Rau et al.   G3-Genes Genomes Genetics

The Mouse Universal Genotyping Array: From Substrains to Subspecies

(2015) Andrew P. Morgan et al.   G3-Genes Genomes Genetics

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

(2015) Brian J. Bennett et al.   PLoS Genetics

Linking traits based on their shared molecular mechanisms

(2015) Yael Oren et al.   eLife

Genetic variation in offspring indirectly influences the quality of maternal behaviour in mice

(2015) David George Ashbrook et al.   eLife

Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease

(2014) David G Ashbrook et al.   BMC GENOMICS

Sex-dependent genetic effects on immune responses to a parasitic nematode

(2014) Kelly S Hayes et al.   BMC GENOMICS

A novel genetic locus linked to pro-inflammatory cytokines after virulent H5N1 virus infection in mice

(2014) Adrianus CM Boon et al.   BMC GENOMICS

Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

(2014) Yibo Wu et al.   CELL

Fine-mapping QTLs in advanced intercross lines and other outbred populations

(2014) Natalia M. Gonzales et al.   MAMMALIAN GENOME

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Efficient multivariate linear mixed model algorithms for genome-wide association studies

(2014) Xiang Zhou et al.   NATURE METHODS

Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains

(2014) John T. Heiker et al.   PHYSIOLOGICAL GENOMICS

Strains and Stressors: An Analysis of Touchscreen Learning in Genetically Diverse Mouse Strains

(2014) Carolyn Graybeal et al.   PLoS One

Unique genetic loci identified for emotional behavior in control and chronic stress conditions

(2014) Kimberly A. K. Carhuatanta et al.   Frontiers in Behavioral Neuroscience

An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement

(2014) Evan G. Williams et al.   PLoS Genetics

Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus

(2014) David G. Ashbrook et al.   Frontiers in Neuroscience

Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations

(2013) L.S. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response

(2013) V. Kumar et al.   SCIENCE

Empirical testing of hypotheses about the evolution of genomic imprinting in mammals

(2013) David G. Ashbrook et al.   Frontiers in Neuroanatomy

Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease

(2013) Megan K. Mulligan et al.   Frontiers in Genetics

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

(2012) Pénélope A. Andreux et al.   CELL

Bilateral Subcortical Heterotopia with Partial Callosal Agenesis in a Mouse Mutant

(2012) G. D. Rosen et al.   CEREBRAL CORTEX

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

(2012) Anatole Ghazalpour et al.   MAMMALIAN GENOME

Bayesian refinement of association signals for 14 loci in 3 common diseases

(2012) Julian B Maller et al.   NATURE GENETICS

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Host Genetics and Chlamydia Disease: Prediction and Validation of Disease Severity Mechanisms

(2012) Isao Miyairi et al.   PLoS One

Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits

(2012) Autumn M. McKnite et al.   PLoS One

Genetic architecture supports mosaic brain evolution and independent brain–body size regulation

(2012) Reinmar Hager et al.   Nature Communications

Genome-Wide Association Mapping of Quantitative Traits in Outbred Mice

(2012) Weidong Zhang et al.   G3-Genes Genomes Genetics

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Predictive, personalized, preventive, participatory (P4) cancer medicine

(2011) Leroy Hood et al.   Nature Reviews Clinical Oncology

R/qtl: high-throughput multiple QTL mapping: Fig. 1.

(2010) Danny Arends et al.   BIOINFORMATICS

A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice

(2010) Zhengsheng Li et al.   PLoS One

Predictive, preventive, personalized and participatory medicine: back to the future

(2010) Charles Auffray et al.   Genome Medicine

Herding cats: the sociology of data integration

(2010) Robert W. Williams   Frontiers in Neuroscience

Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice

(2009) G. D. Rosen et al.   GENES BRAIN AND BEHAVIOR

High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains

(2009) V. M. Philip et al.   GENES BRAIN AND BEHAVIOR

Identification of the UBP1 Locus as a Critical Blood Pressure Determinant Using a Combination of Mouse and Human Genetics

(2009) Hana Koutnikova et al.   PLoS Genetics

Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains

(2008) M. K. Mulligan et al.   GENES BRAIN AND BEHAVIOR

Reporting and interpretation in genome-wide association studies

(2008) Jon Wakefield   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Variation in Mouse Basolateral Amygdala Volume is Associated With Differences in Stress Reactivity and Fear Learning

(2008) Rebecca J Yang et al.   NEUROPSYCHOPHARMACOLOGY

Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels

(2008) Renhua Li et al.   PHYSIOLOGICAL GENOMICS

Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression

(2008) Khyobeni Mozhui et al.   PLoS Genetics