Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

Mutation of the inhibitory ethanol site in GABA A ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

(2017) Yuri A. Blednov et al.   NEUROPHARMACOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Joint mouse–human phenome-wide association to test gene function and disease risk

(2016) Xusheng Wang et al.   Nature Communications

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

(2016) Nicole A. Hawkins et al.   PLoS Genetics

GABRA2Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAASubunit Genes in Human Neural Cultures

(2015) Richard Lieberman et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

WGE: a CRISPR database for genome engineering: Fig. 1.

(2015) Alex Hodgkins et al.   BIOINFORMATICS

Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

(2014)   LANCET NEUROLOGY

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

A meta-analysis of gene expression quantitative trait loci in brain

(2014) Y Kim et al.   Translational Psychiatry

A GABRA2 Variant Is Associated with Increased Stimulation and ‘High’ Following Alcohol Administration

(2013) Albert J. Arias et al.   ALCOHOL AND ALCOHOLISM

Impulsiveness mediates the association betweenGABRA2SNPs and lifetime alcohol problems

(2013) S. Villafuerte et al.   GENES BRAIN AND BEHAVIOR

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder

(2013) Dawei Li et al.   NEUROPSYCHOPHARMACOLOGY

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System

(2013) Andrew R. Bassett et al.   Cell Reports

GABRA2markers moderate the subjective effects of alcohol

(2012) Magdalena Uhart et al.   ADDICTION BIOLOGY

Linking GABAA receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication

(2012) Y.A. Blednov et al.   NEUROPHARMACOLOGY

Complex Control of GABA(A) Receptor Subunit mRNA Expression: Variation, Covariation, and Genetic Regulation

(2012) Megan K. Mulligan et al.   PLoS One

Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence

(2011) G.J. Lydall et al.   NEUROSCIENCE LETTERS

Evaluating Gene Expression in C57BL/6J and DBA/2J Mouse Striatum Using RNA-Seq and Microarrays

(2011) Daniel Bottomly et al.   PLoS One

Binge alcohol drinking is associated with GABAA  2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of GABRA2 in Moderating Subjective Responses to Alcohol

(2010) Sungwon Roh et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Antidepressant-like properties of α2-containing GABAA receptors

(2010) Isabel Vollenweider et al.   BEHAVIOURAL BRAIN RESEARCH

Expression Quantitative Trait Loci: Replication, Tissue- and Sex-Specificity in Mice

(2010) A. van Nas et al.   GENETICS

Loss of Ethanol Conditioned Taste Aversion and Motor Stimulation in Knockin Mice with Ethanol-Insensitive  2-Containing GABAA Receptors

(2010) Y. A. Blednov et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Whole-genome association mapping of gene expression in the human prefrontal cortex

(2010) C Liu et al.   MOLECULAR PSYCHIATRY

A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice

(2010) Zhengsheng Li et al.   PLoS One

Cocaine effects on mouse incentive-learning and human addiction are linked to  2 subunit-containing GABAA receptors

(2010) C. I. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

(2010) J. Raphael Gibbs et al.   PLoS Genetics

Role of GABRA2 in Trajectories of Externalizing Behavior Across Development and Evidence of Moderation by Parental Monitoring

(2009) Danielle M. Dick et al.   ARCHIVES OF GENERAL PSYCHIATRY

The Influence of GABRA2, Childhood Trauma, and Their Interaction on Alcohol, Heroin, and Cocaine Dependence

(2009) Mary-Anne Enoch et al.   BIOLOGICAL PSYCHIATRY

Copy number variation influences gene expression and metabolic traits in mice

(2009) Luz D. Orozco et al.   HUMAN MOLECULAR GENETICS

Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource

(2009) Rupert Overall   Frontiers in Neuroscience

The Role ofGABRA2in Alcohol Dependence, Smoking, and Illicit Drug Use in an Australian Population Sample

(2008) Penelope A. Lind et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Targeted deletion of the GABRA2 gene encoding α2-subunits of GABAA receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates

(2008) C.I. Dixon et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Alpha2-containing GABAA receptors are involved in mediating stimulant effects of cocaine

(2008) H.V. Morris et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The role of GABAA receptors in the development of alcoholism

(2008) Mary-Anne Enoch   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of GABRA2 Variation on Physiological, Psychomotor and Subjective Responses in the Alcohol Challenge Twin Study

(2008) Penelope A. Lind et al.   Twin Research and Human Genetics

Tissue-Specific Genetic Control of Splicing: Implications for the Study of Complex Traits

(2008) Erin L Heinzen et al.   PLOS BIOLOGY

GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence

(2007) M. Soyka et al.   JOURNAL OF PSYCHIATRIC RESEARCH