Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling

Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice

(2019) Eglantine Balland et al.   Cell Reports

Smad7 and Colorectal Carcinogenesis: A Double-Edged Sword

(2019) Edoardo Troncone et al.   Cancers

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

(2018) Garron T. Dodd et al.   DIABETES

Hypothalamic AMPK and energy balance

(2018) Miguel López   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus

(2018) Yuki Yasumoto et al.   MOLECULAR NEUROBIOLOGY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection

(2018) Macarena Pozo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity

(2018) Hyun-A Seong et al.   Cell Death & Disease

Transforming Growth Factor-β1/Smad7 in Intestinal Immunity, Inflammation, and Cancer

(2018) Edoardo Troncone et al.   Frontiers in Immunology

Serine-threonine protein phosphatases: Lost in translation

(2018) Victoria Kolupaeva   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin regulates POMC neuronal plasticity to control glucose metabolism

(2018) Garron T Dodd et al.   eLife

TGF-β signaling regulates p-Akt levels via PP2A during diapause entry in the cotton bollworm, Helicoverpa armigera

(2017) Hai-Yin Li et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insulin action in the brain: Roles in energy and glucose homeostasis

(2017) G. T. Dodd et al.   JOURNAL OF NEUROENDOCRINOLOGY

Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis

(2017) Weiyi Chen et al.   NEUROENDOCRINOLOGY

Toward a Wiring Diagram Understanding of Appetite Control

(2017) Mark L. Andermann et al.   NEURON

Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

(2017) Yi Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A central neural circuit for itch sensation

(2017) Di Mu et al.   SCIENCE

Neuronal control of peripheral insulin sensitivity and glucose metabolism

(2017) Johan Ruud et al.   Nature Communications

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

(2016) Suyong Choi et al.   NATURE CELL BIOLOGY

Mongersen, an oral Smad7 antisense oligonucleotide, in patients with active Crohn’s disease

(2016) Sandro Ardizzone et al.   Therapeutic Advances in Gastroenterology

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

(2015) Mark A. Smith et al.   Cell Reports

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Tissue-specific insulin signaling in the regulation of metabolism and aging

(2014) Jingjing Zhang et al.   IUBMB LIFE

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response

(2014) Jingqi Yan et al.   NATURE MEDICINE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve

(2013) Q. Zhang et al.   DIABETES

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition

(2012) Woo-Kwang Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid

(2012) T. Xia et al.   DIABETES

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

(2011) Xiaohua Yan et al.   BIOCHEMICAL JOURNAL

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice

(2008) H. Tsuneki et al.   DIABETOLOGIA

Smad7 Is Required for the Development and Function of the Heart

(2008) Qian Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY