Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

Intestinal fungi contribute to development of alcoholic liver disease

(2017) An-Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The link between inflammation, bugs, the intestine and the brain in alcohol dependence

(2017) S Leclercq et al.   Translational Psychiatry

Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model

(2016) Ana Rubio-Araiz et al.   ADDICTION BIOLOGY

Microbiota and Alcoholic Liver Disease

(2016) Peng Chen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Metabolomics Analysis Revealed Distinct Cyclic Changes of Metabolites Altered by Chronic Ethanol-Plus-Binge andShpDeficiency

(2016) Melanie Tran et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease

(2016) Irina A. Kirpich et al.   AMERICAN JOURNAL OF PATHOLOGY

Involvement of TLR4 in the long-term epigenetic changes, rewarding and anxiety effects induced by intermittent ethanol treatment in adolescence

(2016) Jorge Montesinos et al.   BRAIN BEHAVIOR AND IMMUNITY

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

(2016) Lirui Wang et al.   Cell Host & Microbe

Expression of Pro-Inflammatory and Hepatoprotective Factors at Early Stages of Alcoholic Liver Disease in Humans and the Impact of Short Term Abstinence

(2016) P. Stärkel et al.   JOURNAL OF HEPATOLOGY

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents

(2016) R. Adron Harris et al.   JOURNAL OF NEUROSCIENCE

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

High resolution metabolomics technology reveals widespread pathway changes of alcoholic liver disease

(2016) Aihua Zhang et al.   Molecular BioSystems

Bidirectional Communication between Liver and Gut during Alcoholic Liver Disease

(2016) Peter Stärkel et al.   SEMINARS IN LIVER DISEASE

Lactobacillus rhamnosus GG supernatant promotes intestinal barrier function, balances T reg and T H 17 cells and ameliorates hepatic injury in a mouse model of chronic-binge alcohol feeding

(2016) Rui-Cong Chen et al.   TOXICOLOGY LETTERS

Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury

(2015) Peng Chen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

(2015) Peng Chen et al.   GASTROENTEROLOGY

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

(2015) M Llopis et al.   GUT

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice

(2015) Peng Chen et al.   HEPATOLOGY

Trends in the management and burden of alcoholic liver disease

(2015) Philippe Mathurin et al.   JOURNAL OF HEPATOLOGY

Lactobacillus rhamnosus CCFM1107 treatment ameliorates alcohol-induced liver injury in a mouse model of chronic alcohol feeding

(2015) Fengwei Tian et al.   JOURNAL OF MICROBIOLOGY

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

(2015) Robin D. Couch et al.   PLoS One

Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men

(2015) Sei Harada et al.   Environmental Health and Preventive Medicine

Tributyrin Supplementation Protects Mice from Acute Ethanol-Induced Gut Injury

(2014) Gail A. Cresci et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Review article: fungal microbiota and digestive diseases

(2014) Z. K. Wang et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol Dependence

(2014) Sophie Leclercq et al.   BIOLOGICAL PSYCHIATRY

Neurologic Manifestations of Gastrointestinal and Liver Diseases

(2014) José M. Ferro et al.   Current Neurology and Neuroscience Reports

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals

(2014) Jacob Tveiten Bjerrum et al.   Metabolomics

Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction-associated proteins

(2014) YING WANG et al.   Molecular Medicine Reports

Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene

(2014) Rana Al-Sadi et al.   PLoS One

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

(2014) Sophie Leclercq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Striking a balance: fungal commensalism versus pathogenesis

(2013) Iliyan D Iliev et al.   CURRENT OPINION IN MICROBIOLOGY

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

(2013) Phillipp Hartmann et al.   HEPATOLOGY

Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

(2013) Dora Lippai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury

(2013) Yuhua Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

(2013) Guoxiang Xie et al.   JOURNAL OF PROTEOME RESEARCH

Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment

(2013) Lara Bull-Otterson et al.   PLoS One

The Associations between Self-Consciousness, Depressive State and Craving to Drink among Alcohol Dependent Patients Undergoing Protracted Withdrawal

(2013) Philippe de Timary et al.   PLoS One

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

Alcohol-induced metabolomic differences in humans

(2013) M Jaremek et al.   Translational Psychiatry

Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism

(2012) Mitzi Dunagan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury

(2012) Yuhua Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

(2012) Sophie Leclercq et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Effects of Ethanol and Acetaldehyde on Tight Junction Integrity: In Vitro Study in a Three Dimensional Intestinal Epithelial Cell Culture Model

(2012) Elhaseen Elamin et al.   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Microbiology of regressive autism

(2011) Sydney M. Finegold et al.   ANAEROBE

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics

(2011) Mark Lyte   BIOESSAYS

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

(2011) James B Adams et al.   BMC GASTROENTEROLOGY

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice

(2011) Y.A. Blednov et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of innate immune genes in brain create the neurobiology of addiction

(2011) F.T. Crews et al.   BRAIN BEHAVIOR AND IMMUNITY

Characterization of fecal microbial communities in patients with liver cirrhosis

(2011) Yanfei Chen et al.   HEPATOLOGY

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

(2011) Ekihiro Seki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Distinct Effects of Protracted Withdrawal on Affect, Craving, Selective Attention and Executive Functions among Alcohol-Dependent Patients

(2010) M. Cordovil De Sousa Uva et al.   ALCOHOL AND ALCOHOLISM

Inactivation of hepatocyte nuclear factor-4α mediates alcohol-induced downregulation of intestinal tight junction proteins

(2010) Wei Zhong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

(2010) Arthur W. Yan et al.   HEPATOLOGY

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis

(2009) Christopher B. Forsyth et al.   ALCOHOL

Intestinal Dysbiosis: A Possible Mechanism of Alcohol-Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

(2009) Ece Mutlu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Suppression of neuro-inflammatory signaling cascade by tocotrienol can prevent chronic alcohol-induced cognitive dysfunction in rats

(2009) Vinod Tiwari et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanism of cytokine modulation of epithelial tight junction barrier

(2009) Rana Al-Sadi   Frontiers in Bioscience-Landmark

Toll-like receptor 2 is critical for induction of Reg3  expression and intestinal clearance of Yersinia pseudotuberculosis

(2009) R Dessein et al.   GUT

Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol

(2009) S. Fernandez-Lizarbe et al.   JOURNAL OF IMMUNOLOGY

Circulating Cytokines as Biomarkers of Alcohol Abuse and Alcoholism

(2009) Rajeshwara N. Achur et al.   Journal of Neuroimmune Pharmacology

Oats Supplementation Prevents Alcohol-Induced Gut Leakiness in Rats by Preventing Alcohol-Induced Oxidative Tissue Damage

(2009) Y. Tang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization

(2009) Ingrid C. McCall et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study

(2008) Irina A. Kirpich et al.   ALCOHOL

Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis

(2008) Vanessa Stadlbauer et al.   JOURNAL OF HEPATOLOGY

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

(2008) Ali Keshavarzian et al.   JOURNAL OF HEPATOLOGY

Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment

(2008) Liya Qin et al.   Journal of Neuroinflammation

Effect of Colonic Bacterial Metabolites on Caco-2 Cell Paracellular Permeability In Vitro

(2008) Roisin Hughes et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Neurobiological mechanisms for opponent motivational processes in addiction

(2008) G. F Koob et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mucin Dynamics in Intestinal Bacterial Infection

(2008) Sara K. Lindén et al.   PLoS One

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY