Toll-Like Receptors, Associated Biological Roles, and Signaling Networks in Non-Mammals

Toll-like receptor (TLR) 22, a non-mammalian TLR in Asian seabass, Lates calcarifer : Characterisation, ontogeny and inductive expression upon exposure with bacteria and ligands

(2018) Anutosh Paria et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A conserved Toll-like receptor-to-NF-κB signaling pathway in the endangered coral Orbicella faveolata

(2018) Leah M. Williams et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification and functional characterization of Toll-like receptor 13 from orange-spotted grouper ( Epinephelus coioides )

(2018) Yaosi Liang et al.   FISH & SHELLFISH IMMUNOLOGY

TLR3 gene in Japanese sea perch ( Lateolabrax japonicus ): Molecular cloning, characterization and expression analysis after bacterial infection

(2018) Pengfei Wang et al.   FISH & SHELLFISH IMMUNOLOGY

SNPs in the Toll1 receptor of Litopenaeus vannamei are associated with immune response

(2018) Defu Yao et al.   FISH & SHELLFISH IMMUNOLOGY

Intracellular TLR22 acts as an inflammation equalizer via suppression of NF-κB and selective activation of MAPK pathway in fish

(2018) Xu Ding et al.   FISH & SHELLFISH IMMUNOLOGY

Toll-receptor 9 gene in the black tiger shrimp ( Penaeus monodon ) induced the activation of the TLR–NF-κB signaling pathway

(2018) Qian Liu et al.   GENE

Endogenous ligands of TLR4 promote unresolving tissue fibrosis: Implications for systemic sclerosis and its targeted therapy

(2018) Swati Bhattacharyya et al.   IMMUNOLOGY LETTERS

SNP-based susceptibility-resistance association and mRNA expression regulation analyses of tlr7 to grass carp Ctenopharyngodon idella reovirus

(2018) J. J. Su et al.   JOURNAL OF FISH BIOLOGY

Evolutionary Origins of Toll-like Receptor Signaling

(2018) Joseph J Brennan et al.   MOLECULAR BIOLOGY AND EVOLUTION

Toll-Like Receptors: Regulators of the Immune Response in the Human Gut

(2018) Hubert Hug et al.   Nutrients

Tlr22 structure and expression characteristic of barbel chub, Squaliobarbus curriculus provides insights into antiviral immunity against infection with grass carp reovirus

(2017) Rong-hua Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Expression analysis of nine Toll-like receptors in yellow catfish ( Pelteobagrus fulvidraco ) responding to Aeromonas hydrophila challenge

(2017) Xiao-Ting Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

Protective immunity against rock bream iridovirus (RBIV) infection and TLR3-mediated type I interferon signaling pathway in rock bream ( Oplegnathus fasciatus ) following poly (I:C) administration

(2017) Myung-Hwa Jung et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular identification and expression analysis of TLR5M and TLR5S from orange-spotted grouper ( Epinepheluscoioides )

(2017) Jian-Shan Bai et al.   FISH & SHELLFISH IMMUNOLOGY

The TLR13-MyD88-NF-κB signalling pathway of Cyclina sinensis plays vital roles in innate immune responses

(2017) Yipeng Ren et al.   FISH & SHELLFISH IMMUNOLOGY

Identification, characterization and expression analysis of TLR5 in the mucosal tissues of turbot ( Scophthalmus maximus L.) following bacterial challenge

(2017) Fengqiao Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Identification, molecular evolution of toll-like receptors in a Tibetan schizothoracine fish ( Gymnocypris eckloni ) and their expression profiles in response to acute hypoxia

(2017) Delin Qi et al.   FISH & SHELLFISH IMMUNOLOGY

Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals

(2017) Mallenahally Kusha Vidya et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Teleost-Specific TLR19 Localizes to Endosome, Recognizes dsRNA, Recruits TRIF, Triggers both IFN and NF-κB Pathways, and Protects Cells from Grass Carp Reovirus Infection

(2017) Jianfei Ji et al.   JOURNAL OF IMMUNOLOGY

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development

(2017) Joseph J. Brennan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schistosomiasis from a Snail’s Perspective: Advances in Snail Immunity

(2017) Emmanuel A. Pila et al.   TRENDS IN PARASITOLOGY

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

(2017) Coen M. Adema et al.   Nature Communications

Activation of Toll Pathway Is Different between Kuruma Shrimp and Drosophila

(2017) Jie-Jie Sun et al.   Frontiers in Immunology

Host species adaptation of TLR5 signalling and flagellin recognition

(2017) Amin Tahoun et al.   Scientific Reports

Cloning, Characterization, and Expression Analysis of MyD88 in Rana dybowskii

(2016) Shudong Niu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Structurally diverse genes encode Tlr2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro

(2016) Andreas Brietzke et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

An LRR-only protein representing a new type of pattern recognition receptor in Chlamys farreri

(2016) Mengqiang Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification and characteristic analysis of TLR28: A novel member of the TLR1 family in teleost

(2016) Yanjin Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Discovery of toll-like receptor 13 exists in the teleost fish: Miiuy croaker (Perciformes, Sciaenidae)

(2016) Yanjin Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Molecular and functional characterization of Toll-like receptor (Tlr)1 and Tlr2 in common carp ( Cyprinus carpio )

(2016) Inge R. Fink et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and expression analysis of toll-like receptor genes (TLR8 and TLR9) in mucosal tissues of turbot ( Scophthalmus maximus L.) following bacterial challenge

(2016) Xiaoyu Dong et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterization of a novel Toll-like receptor 2 homologue in the large yellow croaker Larimichthys crocea

(2016) Jingqun Ao et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and functional characterization of three TLR signaling pathway genes in Cyclina sinensis

(2016) Yipeng Ren et al.   FISH & SHELLFISH IMMUNOLOGY

Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii

(2016) James M Battisti et al.   Innate Immunity

Characterization, expression analysis and localization pattern of toll-like receptor 1 (tlr1) and toll-like receptor 2 (tlr2) genes in grass carpCtenopharyngodon idella

(2016) L. B. He et al.   JOURNAL OF FISH BIOLOGY

A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens

(2016) K. J. Rangan et al.   SCIENCE

A Novel Toll-Like Receptor (TLR) Influences Compatibility between the Gastropod Biomphalaria glabrata, and the Digenean Trematode Schistosoma mansoni

(2016) Emmanuel A. Pila et al.   PLoS Pathogens

TheCaenorhabditis elegansp38 MAPK Gene plays a key role in protection from mycobacteria

(2016) Thushara Galbadage et al.   MicrobiologyOpen

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cloning, sequence analysis and expression profiles of Toll-like receptor 7 from Chinese giant salamander Andrias davidianus

(2015) Lili Huang et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior

(2015) Julia P. Brandt et al.   CURRENT BIOLOGY

The broad pattern recognition spectrum of the Toll-like receptor in mollusk Zhikong scallop Chlamys farreri

(2015) Mengqiang Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A member of the Tlr family is involved in dsRNA innate immune response in Paracentrotus lividus sea urchin

(2015) Roberta Russo et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Characterization and expression analysis of Toll-like receptor 2 gene in large yellow croaker, Larimichthys crocea

(2015) Ze-Jun Fan et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterization of the TLR18 gene in grass carp (Ctenopharyngodon idella)

(2015) Wen-Ji Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Structural and evolutionary characteristics of fish-specific TLR19

(2015) Jinlan Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Structural characterization and evolutionary analysis of fish-specific TLR27

(2015) Jinlan Wang et al.   FISH & SHELLFISH IMMUNOLOGY

A novel vertebrates Toll-like receptor counterpart regulating the anti-microbial peptides expression in the freshwater crayfish, Procambarus clarkii

(2015) Zheng Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Novel Toll/IL-1 Receptor Homologous Region Adaptors Act as Negative Regulators in Amphioxus TLR Signaling

(2015) Jian Peng et al.   JOURNAL OF IMMUNOLOGY

The genome ofAiptasia, a sea anemone model for coral symbiosis

(2015) Sebastian Baumgarten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech

(2015) F. Rodet et al.   Scientific Reports

Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway

(2015) Shuang Zhang et al.   Scientific Reports

Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)

(2015) Madhubanti Basu et al.   3 Biotech

Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)

(2015) Madhubanti Basu et al.   3 Biotech

Massive expansion and functional divergence of innate immune genes in a protostome

(2015) Linlin Zhang et al.   Scientific Reports

Regulation of innate immune responses by transmembrane interactions: Lessons from the TLR family

(2014) Eliran Moshe Reuven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

First evidence of comparative responses of Toll-like receptor 22 (TLR22) to relatively resistant and susceptible Indian farmed carps to Argulus siamensis infection

(2014) Rudra Prasanna Panda et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

TIR-domain-containing protein repertoire of nine anthozoan species reveals coral–specific expansions and uncharacterized proteins

(2014) Angela Z. Poole et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-κB activation

(2014) Chaozheng Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Toll-pathway in tiger shrimp (Penaeus monodon) responds to white spot syndrome virus infection: Evidence through molecular characterisation and expression profiles of MyD88, TRAF6 and TLR genes

(2014) A. Deepika et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterisation of TLR18-21 genes in Atlantic salmon (Salmo salar)

(2014) P.T. Lee et al.   FISH & SHELLFISH IMMUNOLOGY

TLR and IMD signaling pathways from Caligus rogercresseyi (Crustacea: Copepoda): In silico gene expression and SNPs discovery

(2014) V. Valenzuela-Muñoz et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular cloning and characterization of a Toll receptor gene from Macrobrachium rosenbergii

(2014) Chutima Srisuk et al.   FISH & SHELLFISH IMMUNOLOGY

Pattern recognition receptors in the fly: Lessons we can learn from theDrosophila melanogasterimmune system

(2014) Subhamoy Pal et al.   FLY

A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths

(2014) Pierre Boudinot et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses

(2014) A. Matsuo et al.   JOURNAL OF IMMUNOLOGY

Unique Properties of the Chicken TLR4/MD-2 Complex: Selective Lipopolysaccharide Activation of the MyD88-Dependent Pathway

(2014) A. M. Keestra et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor of mud crab, Scylla serrata: molecular characterisation, ontogeny and functional expression analysis following ligand exposure, and bacterial and viral infections

(2014) R. Vidya et al.   MOLECULAR BIOLOGY REPORTS

Episodic Positive Selection in the Evolution of Avian Toll-Like Receptor Innate Immunity Genes

(2014) Catherine E. Grueber et al.   PLoS One

Transcriptome Profiling Reveals Higher Vertebrate Orthologous of Intra-Cytoplasmic Pattern Recognition Receptors in Grey Bamboo Shark

(2014) Tirumurugaan Krishnaswamy Gopalan et al.   PLoS One

Emergence of the A20/ABIN-mediated inhibition of NF- B signaling via modifying the ubiquitinated proteins in a basal chordate

(2014) S. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ancient defense system eliminates unfit cells from developing tissues during cell competition

(2014) S. N. Meyer et al.   SCIENCE

Innate immune system and tissue regeneration in planarians: An area ripe for exploration

(2014) T. Harshani Peiris et al.   SEMINARS IN IMMUNOLOGY

The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition

(2013) Chris R Gissendanner et al.   BMC DEVELOPMENTAL BIOLOGY

Host–microbe interactions: the difficult yet peaceful coexistence of the microbiota and the intestinal mucosa

(2013) Fermín Sánchez de Medina et al.   BRITISH JOURNAL OF NUTRITION

Two adaptor molecules of MyD88 and TRAF6 in Apostichopus japonicus Toll signaling cascade: Molecular cloning and expression analysis

(2013) Yali Lu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2 genes in Atlantic salmon (Salmo salar)

(2013) P.T. Lee et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Pathogen recognition receptors in channel catfish: III Phylogeny and expression analysis of Toll-like receptors

(2013) Jiaren Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Conventional and non-conventional Drosophila Toll signaling

(2013) Scott A. Lindsay et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Molecular characterization and expression analysis of TLR 7 and TLR 8 homologs in large yellow croaker (Pseudosciaena crocea)

(2013) Tanglong Qian et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular characterization and expression analysis of Toll-like receptor 1 from large yellow croaker (Pseudosciaena crocea)

(2013) Kunru Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Expression profiles of toll-like receptors in channel catfish (Ictalurus punctatus) after infection with Ichthyophthirius multifiliis

(2013) Fei Zhao et al.   FISH & SHELLFISH IMMUNOLOGY

Comprehensive survey and genomic characterization of Toll-like receptors (TLRs) in channel catfish, Ictalurus punctatus: identification of novel fish TLRs

(2013) Sylvie M. A. Quiniou et al.   IMMUNOGENETICS

Toll-like receptors (TLRs) in aquatic animals: Signaling pathways, expressions and immune responses

(2013) Pradipta R. Rauta et al.   IMMUNOLOGY LETTERS

Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga

(2013) Jean-François Flot et al.   NATURE

Characteristic and Functional Analysis of Toll-like Receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, Reveals Ancient Origin of TLR-Mediated Innate Immunity

(2013) Yang Zhang et al.   PLoS One

Identification, Characterization, and Functional Analysis of Tube and Pelle Homologs in the Mud Crab Scylla paramamosain

(2013) Xin-Cang Li et al.   PLoS One

Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology

(2013) Ranjeet Singh Mahla   Frontiers in Immunology

Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans

(2012) V. P. Mancuso et al.   DEVELOPMENT

Isolation and analysis of a novel grass carp toll-like receptor 4 (tlr4) gene cluster involved in the response to grass carp reovirus

(2012) Rong Huang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A novel myeloid differentiation factor 88 homolog, SpMyD88, exhibiting SpToll-binding activity in the mud crab Scylla paramamosain

(2012) Xin-Cang Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

NF-κB is required for cnidocyte development in the sea anemone Nematostella vectensis

(2012) Francis S. Wolenski et al.   DEVELOPMENTAL BIOLOGY

An RNAi Screen Reveals Intestinal Regulators of Branching Morphogenesis, Differentiation, and Stem Cell Proliferation in Planarians

(2012) David J. Forsthoefel et al.   DEVELOPMENTAL CELL

Expression profile of toll-like receptor 2 mRNA in selected tissues of shark (Chiloscyllium sp.)

(2012) C. Anandhakumar et al.   FISH & SHELLFISH IMMUNOLOGY

Aj-rel and Aj-p105, two evolutionary conserved NF-κB homologues in sea cucumber (Apostichopus japonicus) and their involvement in LPS induced immunity

(2012) Tingting Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and expression analysis of two Toll-like receptor genes from sea cucumber (Apostichopus japonicus)

(2012) Hongjuan Sun et al.   FISH & SHELLFISH IMMUNOLOGY

NF-κB: where did it come from and why?

(2012) Thomas D. Gilmore et al.   IMMUNOLOGICAL REVIEWS

Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, poly I:C and zebrafish TRIF

(2012) Bikash R. Sahoo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Evolutionary history of the Tricladida and the Platyhelminthes: an up-to-date phylogenetic and systematic account

(2012) Marta Riutort et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response toCandida albicansInfection

(2012) Sara Gorjestani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and expression profiles of grass carp Ctenopharyngodon idella tlr7 in responses to double-stranded RNA and virus infection

(2012) C. Yang et al.   JOURNAL OF FISH BIOLOGY

Positive selection pressure within teleost toll-like receptors tlr21 and tlr22 subfamilies and their response to temperature stress and microbial components in zebrafish

(2012) Arvind Y. M. Sundaram et al.   MOLECULAR BIOLOGY REPORTS

Insights into bilaterian evolution from three spiralian genomes

(2012) Oleg Simakov et al.   NATURE

Genomic insights into the marine sponge microbiome

(2012) Ute Hentschel et al.   NATURE REVIEWS MICROBIOLOGY

The Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses

(2012) Xiaojun Song et al.   PLoS One

MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers

(2012) S. Franzenburg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards an integrated network of coral immune mechanisms

(2012) C. V. Palmer et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structural Basis of TLR5-Flagellin Recognition and Signaling

(2012) S.-i. Yoon et al.   SCIENCE

Dynamic Evolution of Toll-Like Receptor Multigene Families in Echinoderms

(2012) Katherine M. Buckley et al.   Frontiers in Immunology

Toll-Like Receptors of Deuterostome Invertebrates

(2012) Honoo Satake et al.   Frontiers in Immunology

Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

(2011) Manyi Yang et al.   CELL RESEARCH

Comparative and phylogenetic analyses of three TIR domain-containing adaptors in metazoans: Implications for evolution of TLR signaling pathways

(2011) Baojun Wu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Toll-like receptors in bony fish: From genomics to function

(2011) Yniv Palti   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Molecular cloning and characterization of Toll-like receptor 3 in Japanese flounder, Paralichthys olivaceus

(2011) Seong Don Hwang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cloning and characterisation of the SpToll gene from green mud crab, Scylla paramamosain

(2011) Zhongyang Lin et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Toll-like receptor modulators: a patent review (2006 – 2010)

(2011) Shaherin Basith et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Characterization of Toll-like receptor 3 gene in large yellow croaker, Pseudosciaena crocea

(2011) Xue-Na Huang et al.   FISH & SHELLFISH IMMUNOLOGY

A Crassostrea gigas Toll-like receptor and comparative analysis of TLR pathway in invertebrates

(2011) Linlin Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular characterization of toll-like receptor 2 (TLR2), analysis of its inductive expression and associated down-stream signaling molecules following ligands exposure and bacterial infection in the Indian major carp, rohu (Labeo rohita)

(2011) Mrinal Samanta et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular cloning of orange-spotted grouper (Epinephelus coioides) TLR21 and expression analysis post Cryptocaryon irritans infection

(2011) Yan-Wei Li et al.   FISH & SHELLFISH IMMUNOLOGY

The Drosophila Toll Signaling Pathway

(2011) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

Functional Conservation and Innovation of Amphioxus RIP1-Mediated Signaling in Cell Fate Determination

(2011) Jun Li et al.   JOURNAL OF IMMUNOLOGY

Linkage Mapping of Toll-Like Receptors (TLRs) in Japanese Flounder, Paralichthys olivaceus

(2011) Seong Don Hwang et al.   MARINE BIOTECHNOLOGY

Using the Acropora digitifera genome to understand coral responses to environmental change

(2011) Chuya Shinzato et al.   NATURE

The genome sequence of Atlantic cod reveals a unique immune system

(2011) Bastiaan Star et al.   NATURE

The transmembrane LRR protein DMA-1 promotes dendrite branching and growth in C. elegans

(2011) Oliver W Liu et al.   NATURE NEUROSCIENCE

The Shrimp NF-κB Pathway Is Activated by White Spot Syndrome Virus (WSSV) 449 to Facilitate the Expression of WSSV069 (ie1), WSSV303 and WSSV371

(2011) Pei-Hui Wang et al.   PLoS One

Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides

(2011) You Chuan Wei et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Deep sequencing-based transcriptome profiling analysis of bacteria-challenged Lateolabrax japonicus reveals insight into the immune-relevant genes in marine fish

(2010) Li-xin Xiang et al.   BMC GENOMICS

Avian toll-like receptors

(2010) Robert Brownlie et al.   CELL AND TISSUE RESEARCH

Phylogenetic and expression analysis of lamprey toll-like receptors

(2010) Jun Kasamatsu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri

(2010) Mengqiang Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Characterization and immune function of two intracellular sensors, HmTLR1 and HmNLR, in the injured CNS of an invertebrate

(2010) Virginie Cuvillier-Hot et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways

(2010) Marie E. A. Gauthier et al.   EVOLUTION & DEVELOPMENT

Identification, characterization and genetic mapping of TLR1 loci in rainbow trout (Oncorhynchus mykiss)

(2010) Yniv Palti et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular cloning, characterization and expression analysis of TLR9, MyD88 and TRAF6 genes in common carp (Cyprinus carpio)

(2010) Pawapol Kongchum et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular cloning and characterization of Toll-like receptor 14 in Japanese flounder, Paralichthys olivaceus

(2010) Seong Don Hwang et al.   FISH & SHELLFISH IMMUNOLOGY

Dimerization of Toll-like Receptor 3 (TLR3) Is Required for Ligand Binding

(2010) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the vertebrate immune system: insights from the reptilian perspective

(2010) L. M. Zimmerman et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Molecular identification and expression analysis of Toll-like receptor 3 in common carp Cyprinus carpio

(2010) C. Yang et al.   JOURNAL OF FISH BIOLOGY

Amphioxus SARM Involved in Neural Development May Function as a Suppressor of TLR Signaling

(2010) S. Yuan et al.   JOURNAL OF IMMUNOLOGY

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar)

(2009) Ingrid Skjæveland et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss)

(2009) Yniv Palti et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The involvement of suppressors of cytokine signaling 2 (SOCS2) in immune defense responses of Chinese mitten crab Eriocheir sinensis

(2009) Ying Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Genomic organization and expression analysis of Toll-like receptor 3 in grass carp (Ctenopharyngodon idella)

(2009) Jianguo Su et al.   FISH & SHELLFISH IMMUNOLOGY

Evolution of Lipopolysaccharide (LPS) Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF- B Activation

(2009) M. P. Sepulcre et al.   JOURNAL OF IMMUNOLOGY

Deciphering the Immune Function and Regulation by a TLR of the Cytokine EMAPII in the Lesioned Central Nervous System Using a Leech Model

(2009) D. Schikorski et al.   JOURNAL OF IMMUNOLOGY

Genomic and Functional Uniqueness of the TNF Receptor-Associated Factor Gene Family in Amphioxus, the Basal Chordate

(2009) S. Yuan et al.   JOURNAL OF IMMUNOLOGY

An amphioxus TLR with dynamic embryonic expression pattern responses to pathogens and activates NF-κB pathway via MyD88

(2009) Shaochun Yuan et al.   MOLECULAR IMMUNOLOGY

How Hydra senses and destroys microbes

(2009) René Augustin et al.   SEMINARS IN IMMUNOLOGY

Toll-like receptor signaling in bony fish

(2009) Alexander Rebl et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

NF- B in the Immune Response of Drosophila

(2009) C. Hetru et al.   Cold Spring Harbor Perspectives in Biology

nGASP - the nematode genome annotation assessment project

(2008) Avril Coghlan et al.   BMC BIOINFORMATICS

Evolution of the chicken Toll-like receptor gene family: A story of gene gain and gene loss

(2008) Nicholas D Temperley et al.   BMC GENOMICS

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3

(2008) E. Vercammen et al.   CLINICAL MICROBIOLOGY REVIEWS

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Uncovering the evolutionary history of innate immunity: The simple metazoan Hydra uses epithelial cells for host defence

(2008) Thomas C.G. Bosch et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cloning and expression analysis of two alternative splicing toll-like receptor 9 isoforms A and B in large yellow croaker, Pseudosciaena crocea

(2008) C YAO et al.   FISH & SHELLFISH IMMUNOLOGY

A Toll receptor from Chinese shrimp Fenneropenaeus chinensis is responsive to Vibrio anguillarum infection

(2008) C YANG et al.   FISH & SHELLFISH IMMUNOLOGY

Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity

(2008) S. Huang et al.   GENOME RESEARCH

Toll-like receptor 3 regulates Mx expression in rare minnow Gobiocypris rarus after viral infection

(2008) Jianguo Su et al.   IMMUNOGENETICS

Characterization, expression and evolution analysis of Toll-like receptor 1 gene in pufferfish (Tetraodon nigroviridis)

(2008) X-Y. Wu et al.   International Journal of Immunogenetics

Structural Insight into the Mechanism of Activation of the Toll Receptor by the Dimeric Ligand Spätzle

(2008) Monique Gangloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptors — taking an evolutionary approach

(2008) François Leulier et al.   NATURE REVIEWS GENETICS

Toll-like receptor genes (TLRs) from Capitella capitata and Helobdella robusta (Annelida)

(2007) Charis R. Davidson et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Induction of interferon system genes in Atlantic salmon by the imidazoquinoline S-27609, a ligand for Toll-like receptor 7

(2007) O KILENG et al.   FISH & SHELLFISH IMMUNOLOGY

Identification of cDNA encoding Toll receptor, MjToll gene from kuruma shrimp, Marsupenaeus japonicus

(2007) Tohru Mekata et al.   FISH & SHELLFISH IMMUNOLOGY

SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human

(2007) Loh Wei-Ching Belinda et al.   MOLECULAR IMMUNOLOGY