Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

Comparison of the Expression Kinetics and Immunostimulatory Activity of Replicating mRNA, Nonreplicating mRNA, and pDNA after Intradermal Electroporation in Pigs

(2018) Bregje Leyman et al.   MOLECULAR PHARMACEUTICS

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Zika virus vaccines

(2018) Peter Abbink et al.   NATURE REVIEWS MICROBIOLOGY

Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas

(2018) Bruno Hoen et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

(2018) Jesse H. Erasmus et al.   MOLECULAR THERAPY

Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

(2018) Carolina G. O. Lucas et al.   Nature Communications

Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy

(2018) Jose Angel Regla-Nava et al.   Nature Communications

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

(2018) Peter Nambala et al.   Frontiers in Microbiology

mRNA therapeutics deliver a hopeful message

(2018) Zifu Zhong et al.   Nano Today

DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial

(2018) Katherine V. Houser et al.   PLoS One

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

(2017) S Guan et al.   GENE THERAPY

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity

(2017) Thomas E. Morrison et al.   JOURNAL OF VIROLOGY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

(2017) Chao Shan et al.   NATURE MEDICINE

Zika virus-like particle (VLP) based vaccine

(2017) Hélène Boigard et al.   PLoS Neglected Tropical Diseases

Epidemiological and ecological determinants of Zika virus transmission in an urban setting

(2017) José Lourenço et al.   eLife

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

(2017) Jasdave S. Chahal et al.   Scientific Reports

Cargo-Free Nanoparticles Containing Cationic Lipids Induce Reactive Oxygen Species and Cell Death in HepG2 Cells

(2016) Chul-Ho Yun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Mouse Model of Zika Virus Pathogenesis

(2016) Helen M. Lazear et al.   Cell Host & Microbe

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

(2016) Ans De Beuckelaer et al.   MOLECULAR THERAPY

Vaccine protection against Zika virus from Brazil

(2016) Rafael A. Larocca et al.   NATURE

DNA vaccines against Zika virus speed into clinical trials

(2016) Chris Morrison   NATURE REVIEWS DRUG DISCOVERY

The Neurobiology of Zika Virus

(2016) Hongda Li et al.   NEURON

Zika Virus Infection in Pregnant Women in Rio de Janeiro

(2016) Patrícia Brasil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika and the Risk of Microcephaly

(2016) Michael A. Johansson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

(2016) Sonja A. Rasmussen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Countering the Zika epidemic in Latin America

(2016) N. M. Ferguson et al.   SCIENCE

Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

(2016) P. Abbink et al.   SCIENCE

Increase in cases of Guillain-Barré syndrome during a Chikungunya outbreak, French Polynesia, 2014 to 2015

(2015) Erwan Oehler et al.   Eurosurveillance

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

DNA Priming for Seasonal Influenza Vaccine: A Phase 1b Double-Blind Randomized Clinical Trial

(2015) Julie E. Ledgerwood et al.   PLoS One

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

(2014) M Besnard et al.   Eurosurveillance

Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013

(2014) E Oehler et al.   Eurosurveillance

Self-replicating alphavirus RNA vaccines

(2014) Karl Ljungberg et al.   Expert Review of Vaccines

Combination of interleukin-12 gene therapy, metronomic cyclophosphamide and DNA cancer vaccination directs all arms of the immune system towards tumor eradication

(2014) Sofie Denies et al.   JOURNAL OF CONTROLLED RELEASE

CD8+T Cells Prevent Antigen-Induced Antibody-Dependent Enhancement of Dengue Disease in Mice

(2014) Raphaël M. Zellweger et al.   JOURNAL OF IMMUNOLOGY

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonclinical biodistribution, integration, and toxicology evaluations of an H5N1 pandemic influenza plasmid DNA vaccine formulated with Vaxfectin®

(2011) John Doukas et al.   VACCINE

Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-  In Vivo

(2009) S. Lienenklaus et al.   JOURNAL OF IMMUNOLOGY