mRNA

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities

(2012) J. Tel et al.   BLOOD

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

(2012) E. H. J. G. Aarntzen et al.   CLINICAL CANCER RESEARCH

Epitope and HLA-type independent monitoring of antigen-specific T-cells after treatment with dendritic cells presenting full-length tumor antigens

(2012) An M.T. Van Nuffel et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma Patients

(2012) An MT Van Nuffel et al.   MOLECULAR THERAPY

RNA-based vaccines

(2012) Jeffrey B. Ulmer et al.   VACCINE

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

(2011) Marie-Luce De Temmerman et al.   BIOMATERIALS

Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient

(2011) An M. T. Van Nuffel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes

(2011) Else M. Inderberg Suso et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines

(2011) S. Kreiter et al.   CANCER RESEARCH

New Challenges in Endpoints for Drug Development in Advanced Melanoma

(2011) A. Ribas et al.   CLINICAL CANCER RESEARCH

Route of Administration Modulates the Induction of Dendritic Cell Vaccine-Induced Antigen-Specific T Cells in Advanced Melanoma Patients

(2011) W. J. Lesterhuis et al.   CLINICAL CANCER RESEARCH

Tumor vaccination using messenger RNA: prospects of a future therapy

(2011) Sebastian Kreiter et al.   CURRENT OPINION IN IMMUNOLOGY

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

mRNA: delivering an antitumor message?

(2011) Sandra Van Lint et al.   Immunotherapy

Therapeutic Vaccination With an Autologous mRNA Electroporated Dendritic Cell Vaccine in Patients With Advanced Melanoma

(2011) Sofie Wilgenhof et al.   JOURNAL OF IMMUNOTHERAPY

Restoration of tumor equilibrium after immunotherapy for advanced melanoma

(2011) Sofie Wilgenhof et al.   MELANOMA RESEARCH

Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

(2011) Stephan Fath et al.   PLoS One

Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy

(2010) Gerty Schreibelt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

RNA Vaccines in Cancer Treatment

(2010) Anita Bringmann et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

(2010) V. F. Van Tendeloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ Expression of Tumor Antigens by Messenger RNA-Electroporated Dendritic Cells in Lymph Nodes of Melanoma Patients

(2009) D. H. Schuurhuis et al.   CANCER RESEARCH

Physiological Role of Plasmacytoid Dendritic Cells and Their Potential Use in Cancer Immunity

(2009) Jorge Schettini et al.   Clinical & Developmental Immunology

Limited Amounts of Dendritic Cells Migrate into the T-Cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients

(2009) P. Verdijk et al.   CLINICAL CANCER RESEARCH

Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients

(2009) A. Bonehill et al.   CLINICAL CANCER RESEARCH

Clinical and Immunologic Effects of Intranodal Autologous Tumor Lysate-Dendritic Cell Vaccine with Aldesleukin (Interleukin 2) and IFN- 2a Therapy in Metastatic Renal Cell Carcinoma Patients

(2009) T. Schwaab et al.   CLINICAL CANCER RESEARCH

Intralymphatic immunotherapy

(2009) Gabriela Senti et al.   Current Opinion in Allergy and Clinical Immunology

Intralymphatic Injections as a New Administration Route for Allergen-Specific Immunotherapy

(2009) Julia M. Martínez-Gómez et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Intranodal Immunization With a Vaccinia Virus Encoding Multiple Antigenic Epitopes and Costimulatory Molecules in Metastatic Melanoma

(2009) Michel Adamina et al.   MOLECULAR THERAPY

Dendritic cell vaccines in melanoma: From promise to proof?

(2008) W.J. Lesterhuis et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Immunosuppression induced by immature dendritic cells is mediated by TGF-β/IL-10 double-positive CD4+regulatory T cells

(2008) N. Cools et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

(2008) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

(2008) Aude Bonehill et al.   MOLECULAR THERAPY