New insights into extracellular vesicle biogenesis and function

Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures

(2019) Minwook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

(2019) Vivek Agrahari et al.   TRENDS IN BIOTECHNOLOGY

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity

(2019) Arash Latifkar et al.   DEVELOPMENTAL CELL

Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential

(2018) Michael J. Lukey et al.   CANCER CELL

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

(2018) Marat S. Pavlyukov et al.   CANCER CELL

Extracellular Vesicles in Human Reproduction in Health and Disease

(2018) Carlos Simon et al.   ENDOCRINE REVIEWS

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis

(2018) Thambi Dorai et al.   PROSTATE

Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment

(2018) Gorjana Rackov et al.   Frontiers in Physiology

Hodgkin Lymphoma-Derived Extracellular Vesicles Change the Secretome of Fibroblasts Toward a CAF Phenotype

(2018) Bastian Dörsam et al.   Frontiers in Immunology

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Current Status of Stem Cell Therapies in Tissue Repair and Regeneration

(2018) Tapan Kumar Giri et al.   Current Stem Cell Research & Therapy

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

(2018) Ioanna Keklikoglou et al.   NATURE CELL BIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

(2018) Guanguan Qiu et al.   Stem Cell Research & Therapy

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells

(2017) Young Hye Song et al.   MATRIX BIOLOGY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

(2017) Qiyu Feng et al.   Nature Communications

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology

(2016) Laura M. Desrochers et al.   DEVELOPMENTAL CELL

Exosomes in the Pathology of Neurodegenerative Diseases

(2016) Jason Howitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation

(2016) Bridget T. Kreger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

(2016) Laura M. Desrochers et al.   Nature Communications

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Extracellular Vesicles: Evolving Factors in Stem Cell Biology

(2016) Muhammad Nawaz et al.   Stem Cells International

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance

(2016) Bridget Kreger et al.   Cancers

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

(2015) Yuxuan Miao et al.   CELL

Inducing pluripotencyin vitro: recent advances and highlights in induced pluripotent stem cells generation and pluripotency reprogramming

(2015) I. K. Rony et al.   CELL PROLIFERATION

Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

(2015) Xiaomei Teng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

(2015) Bin Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Regenerative medicine: Current therapies and future directions

(2015) Angelo S. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

The Neutral Sphingomyelinase Pathway Regulates Packaging of the Prion Protein into Exosomes

(2014) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Vesicles in Luminal Fluid of the Ovine Uterus

(2014) Gregory Burns et al.   PLoS One

ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

(2013) Sabrina Schlienger et al.   MOLECULAR BIOLOGY OF THE CELL

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Endometrial Exosomes/Microvesicles in the Uterine Microenvironment: A New Paradigm for Embryo-Endometrial Cross Talk at Implantation

(2013) York Hunt Ng et al.   PLoS One

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Tumor-cell-derived microvesicles as carriers of molecular information in cancer

(2012) Vilma R. Martins et al.   CURRENT OPINION IN ONCOLOGY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Embryonic Stem Cell-Derived Microvesicles Induce Gene Expression Changes in Müller Cells of the Retina

(2012) Diana Katsman et al.   PLoS One

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

(2011) Leo Timmers et al.   Stem Cell Research

Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands

(2010) Lola Fernández-Messina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Leukemia inhibitory factor and interleukin-11: Critical regulators in the establishment of pregnancy

(2009) Premila Paiva et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE