Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches
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Title
Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches
Authors
Keywords
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Journal
Genes
Volume 12, Issue 1, Pages 112
Publisher
MDPI AG
Online
2021-01-19
DOI
10.3390/genes12010112
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Note: Only part of the references are listed.- Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients
- (2020) Tien-Chun Yang et al. HUMAN MOLECULAR GENETICS
- Dual SMAD inhibition and Wnt inhibition enable efficient and reproducible differentiations of induced pluripotent stem cells into retinal ganglion cells
- (2020) Venkata R. M. Chavali et al. Scientific Reports
- HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration
- (2020) Sunao Sugita et al. Journal of Clinical Medicine
- Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber’s Hereditary optic Neuropathy (LHON)
- (2020) Camille Peron et al. Stem Cell Research
- Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy
- (2020) Patrick Yu-Wai-Man et al. Science Translational Medicine
- Polybenzyl Glutamate Biocompatible Scaffold Promotes the Efficiency of Retinal Differentiation toward Retinal Ganglion Cell Lineage from Human-Induced Pluripotent Stem Cells
- (2019) Ta-Ching Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences
- (2019) Carla B. Mellough et al. Stem Cells Translational Medicine
- Pluripotent Stem Cells as Models of Retina Development
- (2019) Amy Q. Lu et al. MOLECULAR NEUROBIOLOGY
- Mechanisms for the maintenance and regulation of axonal energy supply
- (2019) Kelly Anne Chamberlain et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids, and Disease Modeling
- (2019) Richard M. Eglen et al. SLAS Technology
- P3HT:Bebq2-Based Photovoltaic Device Enhances Differentiation of hiPSC-Derived Retinal Ganglion Cells
- (2019) Chih-Chen Hsu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells
- (2019) Yang et al. Cells
- OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database
- (2019) Bastien Le Roux et al. Orphanet Journal of Rare Diseases
- Axonal Transport and Mitochondrial Function in Neurons
- (2019) Amrita Mandal et al. Frontiers in Cellular Neuroscience
- Modulation of osmotic stress-induced TRPV1 expression rescues human iPSC-derived retinal ganglion cells through PKA
- (2019) Chih-Chien Hsu et al. Stem Cell Research & Therapy
- Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform
- (2019) Kevin Achberger et al. eLife
- Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish
- (2019) Grace E Lidgerwood et al. CURRENT OPINION IN PHARMACOLOGY
- Derivation of a human DOA iPSC line, IISHDOi006-A, with a mutation in the ACO2 gene: c.1999G>A; p.Glu667Lys
- (2019) Victoria Cerrada et al. Stem Cell Research
- Deciphering retinal diseases through the generation of three dimensional stem cell-derived organoids: Concise Review
- (2019) Ana Artero Castro et al. STEM CELLS
- The Challenge of Bringing iPSCs to the Patient
- (2019) María del Carmen Ortuño-Costela et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inducing human induced pluripotent stem cell differentiation through embryoid bodies: A practical and stable approach
- (2019) Ning-Ning Guo et al. World Journal of Stem Cells
- Stem cell-based retina models
- (2018) Kevin Achberger et al. ADVANCED DRUG DELIVERY REVIEWS
- Bioactivity and gene expression profiles of hiPSC-generated retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy
- (2018) You-Ren Wu et al. EXPERIMENTAL CELL RESEARCH
- Ethical and Safety Issues of Stem Cell-Based Therapy
- (2018) Vladislav Volarevic et al. International Journal of Medical Sciences
- Research progress on human genes involved in the pathogenesis of glaucoma (Review)
- (2018) Hong‑Wei Wang et al. Molecular Medicine Reports
- Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease
- (2018) Luciana Rigoli et al. PEDIATRIC RESEARCH
- Generation of patient-specific induced pluripotent stem cells from Leber's hereditary optic neuropathy
- (2018) Huai-En Lu et al. Stem Cell Research
- Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9
- (2018) Ronen Ben Jehuda et al. Stem Cell Reviews and Reports
- Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency
- (2018) Dean Hallam et al. STEM CELLS
- Use of bioreactors for culturing human retinal organoids improves photoreceptor yields
- (2018) Patrick Ovando-Roche et al. Stem Cell Research & Therapy
- Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9
- (2018) Ronen Ben Jehuda et al. Stem Cell Reviews and Reports
- The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
- (2018) Florence A. Giger et al. Frontiers in Neuroscience
- Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors
- (2018) Tyler DiStefano et al. Stem Cell Reports
- Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients
- (2018) Wen-Li Deng et al. Stem Cell Reports
- Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells
- (2018) Clarisse M. Fligor et al. Scientific Reports
- Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
- (2018) Elizabeth E. Capowski et al. DEVELOPMENT
- Organ-on-a-chip technologies that can transform ophthalmic drug discovery and disease modeling
- (2018) Jasmin C. Haderspeck et al. Expert Opinion on Drug Discovery
- Inherited eye-related disorders due to mitochondrial dysfunction
- (2017) Patrick Yu-Wai-Man et al. HUMAN MOLECULAR GENETICS
- Elongation of Axon Extension for Human iPSC-Derived Retinal Ganglion Cells by a Nano-Imprinted Scaffold
- (2017) Tien-Chun Yang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies
- (2017) Yoko A. Ito et al. MITOCHONDRION
- Incomplete penetrance in mitochondrial optic neuropathies
- (2017) Leonardo Caporali et al. MITOCHONDRION
- Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
- (2017) Michiko Mandai et al. NEW ENGLAND JOURNAL OF MEDICINE
- Establishment of a human DOA 'plus' iPSC line, IISHDOi003-A, with the mutation in the OPA1 gene: c.1635C > A; p.Ser545Arg
- (2017) Francisco Zurita-Díaz et al. Stem Cell Research
- Dominant Optic Atrophy and Leber’s Hereditary Optic Neuropathy: Update on Clinical Features and Current Therapeutic Approaches
- (2017) Bo Young Chun et al. Seminars in Pediatric Neurology
- A neurodegenerative perspective on mitochondrial optic neuropathies
- (2016) Patrick Yu-Wai-Man et al. ACTA NEUROPATHOLOGICA
- Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells
- (2016) Sandy Hung et al. Aging-US
- Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions
- (2016) William T. Hendriks et al. Cell Stem Cell
- Induced Pluripotent Stem Cells Meet Genome Editing
- (2016) Dirk Hockemeyer et al. Cell Stem Cell
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- (2016) Bo Y. Chun et al. CURRENT OPINION IN OPHTHALMOLOGY
- The use of induced pluripotent stem cells for studying and treating optic neuropathies
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- Translation of Human-Induced Pluripotent Stem Cells
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- Induced pluripotent stem cell technology: a decade of progress
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- Pluripotent stem cells in disease modelling and drug discovery
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- Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies
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- Generation of a human iPSC line from a patient with an optic atrophy ‘plus’ phenotype due to a mutation in the OPA1 gene
- (2016) Teresa Galera-Monge et al. Stem Cell Research
- Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration
- (2016) Sarah K. Ohlemacher et al. STEM CELLS
- Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism
- (2016) Pooja Teotia et al. STEM CELLS
- Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets
- (2016) Jing Chen et al. Stem Cell Research & Therapy
- Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid
- (2016) Albert Lowe et al. Stem Cell Reports
- cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness
- (2016) Luke A. Wiley et al. Scientific Reports
- Enriched retinal ganglion cells derived from human embryonic stem cells
- (2016) Katherine P. Gill et al. Scientific Reports
- Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease
- (2015) Gráinne S. Gorman et al. ANNALS OF NEUROLOGY
- The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation
- (2015) Pingping Jiang et al. HUMAN MOLECULAR GENETICS
- RIKEN suspends first clinical trial involving induced pluripotent stem cells
- (2015) Ken Garber NATURE BIOTECHNOLOGY
- Continuous Non-Cell Autonomous Reprogramming to Generate Retinal Ganglion Cells for Glaucomatous Neuropathy
- (2015) Sowmya Parameswaran et al. STEM CELLS
- Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue
- (2015) Atsushi Kuwahara et al. Nature Communications
- Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells
- (2015) Taku Tanaka et al. Scientific Reports
- Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line
- (2015) Valentin M. Sluch et al. Scientific Reports
- Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold
- (2014) Karl E. Kador et al. Acta Biomaterialia
- Early-onset Behr syndrome due to compound heterozygous mutations in OPA1
- (2014) Dominique Bonneau et al. BRAIN
- Treatment strategies for inherited optic neuropathies: past, present and future
- (2014) P Yu-Wai-Man et al. EYE
- The Pathophysiology and Treatment of Glaucoma
- (2014) Robert N. Weinreb et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy
- (2014) Metodi Dimitrov Metodiev et al. JOURNAL OF MEDICAL GENETICS
- Costeff syndrome: clinical features and natural history
- (2014) Gilad Yahalom et al. JOURNAL OF NEUROLOGY
- From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium
- (2014) S. Reichman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs
- (2014) Xiufeng Zhong et al. Nature Communications
- Common and Rare Genetic Risk Factors for Glaucoma
- (2014) R. Wang et al. Cold Spring Harbor Perspectives in Medicine
- Chemically Induced Specification of Retinal Ganglion Cells From Human Embryonic and Induced Pluripotent Stem Cells
- (2014) Hamidreza Riazifar et al. Stem Cells Translational Medicine
- Tissue engineering the retinal ganglion cell nerve fiber layer
- (2013) Karl E. Kador et al. BIOMATERIALS
- Persistence of the treatment effect of idebenone in Leber’s hereditary optic neuropathy
- (2013) T. Klopstock et al. BRAIN
- Identification of the variants in PARL, the nuclear modifier gene, responsible for the expression of LHON patients in Thailand
- (2013) Rochmy Istikharah et al. EXPERIMENTAL EYE RESEARCH
- Genetic and phenotypic variability of optic neuropathies
- (2013) Teresa Neuhann et al. Expert Review of Neurotherapeutics
- An eye on eye development
- (2013) Rebecca Sinn et al. MECHANISMS OF DEVELOPMENT
- Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations
- (2013) G. Pfeffer et al. NEUROLOGY
- Dominant Optic Atrophy: Novel OPA1 Mutations and Revised Prevalence Estimates
- (2013) Patrick Yu-Wai-Man et al. OPHTHALMOLOGY
- Engrafted Human Induced Pluripotent Stem Cell-Derived Anterior Specified Neural Progenitors Protect the Rat Crushed Optic Nerve
- (2013) Leila Satarian et al. PLoS One
- Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability
- (2013) Dao-Yi Yu et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/ -catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures
- (2013) G. Lupo et al. Open Biology
- Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs
- (2012) Tokushige Nakano et al. Cell Stem Cell
- Treatment of hereditary optic neuropathies
- (2012) Nancy J. Newman Nature Reviews Neurology
- Dominant optic atrophy
- (2012) Guy Lenaers et al. Orphanet Journal of Rare Diseases
- Mouse mtDNA mutant model of Leber hereditary optic neuropathy
- (2012) C. S. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Eye Development and Retinogenesis
- (2012) W. Heavner et al. Cold Spring Harbor Perspectives in Biology
- Use of a Synthetic Xeno-Free Culture Substrate for Induced Pluripotent Stem Cell Induction and Retinal Differentiation
- (2012) Budd A. Tucker et al. Stem Cells Translational Medicine
- A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16
- (2011) Valerio Carelli et al. HUMAN MOLECULAR GENETICS
- Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment
- (2011) Jason S. Meyer et al. STEM CELLS
- Multi-system neurological disease is common in patients with OPA1 mutations
- (2010) P. Yu-Wai-Man et al. BRAIN
- Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies
- (2010) A.H. Dahlmann-Noor et al. DRUG DISCOVERY TODAY
- Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies
- (2010) Patrick Yu-Wai-Man et al. PROGRESS IN RETINAL AND EYE RESEARCH
- The Neuro-ophthalmology of Mitochondrial Disease
- (2010) J. Alexander Fraser et al. SURVEY OF OPHTHALMOLOGY
- Genetic Bases for Glaucoma
- (2010) Nobuo Fuse TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- TMEM126A, Encoding a Mitochondrial Protein, Is Mutated in Autosomal-Recessive Nonsyndromic Optic Atrophy
- (2009) Sylvain Hanein et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genetically determined optic neuropathies
- (2009) Dan Milea et al. CURRENT OPINION IN NEUROLOGY
- ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells
- (2008) L. Pan et al. DEVELOPMENT
- Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
- (2008) Y. Elkabetz et al. GENES & DEVELOPMENT
- Inherited mitochondrial optic neuropathies
- (2008) P Yu-Wai-Man et al. JOURNAL OF MEDICAL GENETICS
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