Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage

(2016) Akshayalakshmi Sridhar et al.   Stem Cells Translational Medicine

Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells

(2015) Yuki Maekawa et al.   CURRENT EYE RESEARCH

Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery

(2015) Stefania Corti et al.   Expert Opinion on Drug Discovery

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

(2015) Virginia B. Mattis et al.   HUMAN MOLECULAR GENETICS

Visual impairment in an optineurin mouse model of primary open-angle glaucoma

(2015) Henry C. Tseng et al.   NEUROBIOLOGY OF AGING

Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells

(2015) Taku Tanaka et al.   Scientific Reports

Connecting the Retina to the Brain

(2014) Lynda Erskine et al.   ASN Neuro

CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype

(2014) E R Burnight et al.   GENE THERAPY

Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells

(2014) Nele Schwarz et al.   HUMAN MOLECULAR GENETICS

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Modeling Human Retinal Development with Patient-Specific Induced Pluripotent Stem Cells Reveals Multiple Roles for Visual System Homeobox 2

(2014) M. Joseph Phillips et al.   STEM CELLS

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa

(2014) Tetsu Yoshida et al.   Molecular Brain

Concise Review: Drug Discovery in the Age of the Induced Pluripotent Stem Cell

(2014) Huaising C. Ko et al.   Stem Cells Translational Medicine

Chemically Induced Specification of Retinal Ganglion Cells From Human Embryonic and Induced Pluripotent Stem Cells

(2014) Hamidreza Riazifar et al.   Stem Cells Translational Medicine

Effects of mutations and deletions in the human optineurin gene

(2014) Sanja Turturro et al.   SpringerPlus

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

(2013) Karl R. Koehler et al.   NATURE

Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin

(2013) A. H. Rowe et al.   SCIENCE

Measuring and using light in the melanopsin age

(2013) Robert J. Lucas et al.   TRENDS IN NEUROSCIENCES

Nonxenogeneic Growth and Retinal Differentiation of Human Induced Pluripotent Stem Cells

(2013) Akshayalakshmi Sridhar et al.   Stem Cells Translational Medicine

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration

(2012) Ruchira Singh et al.   HUMAN MOLECULAR GENETICS

Modeling psychiatric disorders at the cellular and network levels

(2012) K J Brennand et al.   MOLECULAR PSYCHIATRY

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

(2012) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Whole Number, Distribution and Co-Expression of Brn3 Transcription Factors in Retinal Ganglion Cells of Adult Albino and Pigmented Rats

(2012) Francisco M. Nadal-Nicolás et al.   PLoS One

Diverse types of ganglion cell photoreceptors in the mammalian retina

(2012) Andrea Sand et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

Efficient Stage-Specific Differentiation of Human Pluripotent Stem Cells Toward Retinal Photoreceptor Cells

(2012) Carla B. Mellough et al.   STEM CELLS

Brief Report: Self-Organizing Neuroepithelium from Human Pluripotent Stem Cells Facilitates Derivation of Photoreceptors

(2012) Cédric Boucherie et al.   STEM CELLS

Control of Organelle Size: The Golgi Complex

(2011) Debrup Sengupta et al.   Annual Review of Cell and Developmental Biology

Primary open-angle glaucoma genes

(2011) J H Fingert   EYE

Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

(2011) M. C. Marchetto et al.   HUMAN MOLECULAR GENETICS

Modeling Retinal Degeneration Using Patient-Specific Induced Pluripotent Stem Cells

(2011) Zi-Bing Jin et al.   PLoS One

Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment

(2011) Jason S. Meyer et al.   STEM CELLS

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Mechanisms of retinal ganglion cell injury and defense in glaucoma

(2010) Juan Qu et al.   EXPERIMENTAL EYE RESEARCH

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

(2010) Zai-Long Chi et al.   HUMAN MOLECULAR GENETICS

Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma Gene

(2010) Hongyu Ying et al.   PLoS One

Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells

(2010) Deepak A. Lamba et al.   PLoS One

Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: Analysis of wild type and mutant cells using genetically-directed sparse labeling

(2010) Tudor Constantin Badea et al.   VISION RESEARCH

Intraocular pressure measurements throughout the 24 h

(2009) Harmohina Bagga et al.   CURRENT OPINION IN OPHTHALMOLOGY

Modeling early retinal development with human embryonic and induced pluripotent stem cells

(2009) J. S. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetics of primary open-angle glaucoma: A review

(2008) R. Rand Allingham et al.   EXPERIMENTAL EYE RESEARCH

Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

(2008) Fumitaka Osakada et al.   NATURE BIOTECHNOLOGY

The developing and evolving retina: Using time to organize form

(2007) Barbara L. Finlay   BRAIN RESEARCH