Journal
STEM CELL RESEARCH
Volume 28, Issue -, Pages 56-60Publisher
ELSEVIER
DOI: 10.1016/j.scr.2018.01.029
Keywords
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Funding
- Ministry of Science and Technology (MOST) [MOST 106-2319-B-001-003]
- Taiwan Mouse Clinic [MOST 105-2325-B001-010]
- MOST [MOST 106-2633-B-009-001, MOST 106-2321-B-010-006, MOST 106-2119-M-010-001, MOST 106-3114-B-010-002]
- Academia Sinica [104-0210-01-09-02, 105-0210-01-13-01, 106-0210-01-15-02]
- Ministry of Health and Welfare [MOHW 106-TDU-B-211-113001, MOHW 106-TDU-B-211-144003]
- National Health Research Institutes [NHRI-EX106-10621BI]
- TVGH [V106E-004-2, V106C-001]
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Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease caused by homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. In this report, we generated an induced pluripotent stem cell (iPSCs) line, TVGH-iPSC-010-09, from the peripheral blood mononuclear cells of a female patient with Leber's hereditary optic neuropathy (LHON) by using the Sendai-virus delivery system. The resulting iPSCs retained the disease-causing mitochondrial DNA mutation, expressed pluripotent markers and could differentiate into the three germ layers. We believe LHON patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease. (c) 2017 The Authors. Published by Elsevier B.V.
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