Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

Methionine is a metabolic dependency of tumor-initiating cells

(2019) Zhenxun Wang et al.   NATURE MEDICINE

Definitions and guidelines for research on antibiotic persistence

(2019) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism

(2019) Karin Ortmayr et al.   Nature Communications

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

(2019) Pei-Hsuan Chen et al.   MOLECULAR CELL

Chemotaxis as a navigation strategy to boost range expansion

(2019) Jonas Cremer et al.   NATURE

Galactose 1‐phosphate accumulates to high levels in galactose‐treated cells due to low GALT activity and absence of product inhibition of GALK

(2019) Sher Li Oh et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Resource allocation and metabolism: the search for governing principles

(2018) Markus Basan   CURRENT OPINION IN MICROBIOLOGY

Regulation of ATP utilization during metastatic cell migration by collagen architecture

(2018) Matthew R. Zanotelli et al.   MOLECULAR BIOLOGY OF THE CELL

Alterations in Cell Motility, Proliferation, and Metabolism in Novel Models of Acquired Temozolomide Resistant Glioblastoma

(2018) D. M. Tiek et al.   Scientific Reports

Four Key Steps Control Glycolytic Flux in Mammalian Cells

(2018) Lukas Bahati Tanner et al.   Cell Systems

A Landscape of Metabolic Variation across Tumor Types

(2018) Ed Reznik et al.   Cell Systems

Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance

(2018) Ryan J. Atkins et al.   EXPERIMENTAL CELL RESEARCH

Few regulatory metabolites coordinate expression of central metabolic genes in Escherichia coli

(2017) Karl Kochanowski et al.   Molecular Systems Biology

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment

(2017) Riina Kaukonen et al.   Nature Protocols

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

(2017) Milica Momcilovic et al.   Cell Reports

Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells

(2017) Giovanni C. Forcina et al.   Cell Systems

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

(2017) Keisha N. Hardeman et al.   Scientific Reports

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Persistence to anti-cancer treatments in the stationary to proliferating transition

(2016) Sivan Pearl Mizrahi et al.   CELL CYCLE

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Quantitative Multiscale Cell Imaging in Controlled 3D Microenvironments

(2016) Erik S. Welf et al.   DEVELOPMENTAL CELL

An unbiased metric of antiproliferative drug effect in vitro

(2016) Leonard A Harris et al.   NATURE METHODS

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis

(2016) Yanfeng Liu et al.   Nature Communications

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Overflow metabolism in Escherichia coli results from efficient proteome allocation

(2015) Markus Basan et al.   NATURE

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

(2014) D. Raha et al.   CANCER RESEARCH

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration

(2014) K. Yizhak et al.   Molecular Systems Biology

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor

(2014) Akiko Murakami et al.   PLoS One

Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells

(2014) Erina Takai et al.   Purinergic Signalling

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

(2013) M Ahmadi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Cell migration or cytokinesis and proliferation? – Revisiting the “go or grow” hypothesis in cancer cells in vitro

(2013) Tamás Garay et al.   EXPERIMENTAL CELL RESEARCH

Dissecting specific and global transcriptional regulation of bacterial gene expression

(2013) L. Gerosa et al.   Molecular Systems Biology

Shared control of gene expression in bacteria by transcription factors and global physiology of the cell

(2013) S. Berthoumieux et al.   Molecular Systems Biology

Hypoxia induces a phase transition within a kinase signaling network in cancer cells

(2013) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bacterial growth laws and their applications

(2011) Matthew Scott et al.   CURRENT OPINION IN BIOTECHNOLOGY

Delineation of a Bacterial Starvation Stress Response Network Which Can Mediate Antibiotic Tolerance Development

(2010) D. K. C. Fung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AIC model selection and multimodel inference in behavioral ecology: some background, observations, and comparisons

(2010) Kenneth P. Burnham et al.   BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

(2007) Matthew J. Brauer et al.   MOLECULAR BIOLOGY OF THE CELL