Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells

(2020) Hiraku Tsujimoto et al.   Cell Reports

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development

(2019) Mazène Hochane et al.   PLOS BIOLOGY

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Reporter‐based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation

(2019) Sara E Howden et al.   EMBO REPORTS

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

(2019) Ayshwarya Subramanian et al.   Nature Communications

Generation of branching ureteric bud tissues from human pluripotent stem cells

(2018) Shin-Ichi Mae et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

(2018) Stefan M. Czerniecki et al.   Cell Stem Cell

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney

(2018) Keri A. Drake et al.   Scientific Reports

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

(2018) Cathelijne W. van den Berg et al.   Stem Cell Reports

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney

(2018) Rajasree Menon et al.   DEVELOPMENT

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evaluation of variability in human kidney organoids

(2018) Belinda Phipson et al.   NATURE METHODS

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

(2018) Trygve E. Bakken et al.   PLoS One

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

(2018) Kiara C. Eldred et al.   SCIENCE

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

(2017) Max Werth et al.   eLife

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy

(2016) Anika Klingberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture

(2015) William L. Rice et al.   PLoS One

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Collecting Duct Principal Cell Transport Processes and Their Regulation

(2014) D. Pearce et al.   Clinical Journal of the American Society of Nephrology

The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor–like cells

(2014) Yun Xia et al.   Nature Protocols

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

(2013) Atsuhiro Taguchi et al.   Cell Stem Cell

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

(2013) M. Takasato et al.   NATURE CELL BIOLOGY

Renal tubular dysgenesis

(2013) Marie-Claire Gubler   PEDIATRIC NEPHROLOGY

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Using mouse models to understand normal and abnormal urogenital tract development

(2012) Cathy Mendelsohn   Organogenesis

The GUDMAP database - an online resource for genitourinary research

(2011) S. D. Harding et al.   DEVELOPMENT

The Ngal reporter mouse detects the response of the kidney to injury in real time

(2011) Neal Paragas et al.   NATURE MEDICINE