Article
Biochemistry & Molecular Biology
Arvid Herrmann, Pantelis Livanos, Steffi Zimmermann, Kenneth Berendzen, Leander Rohr, Elisabeth Lipka, Sabine Mueller
Summary: Experimental evidence is provided for the function of Arabidopsis KINESIN-12E in spindle assembly. The localization of Kinesin-12E is mitosis-stage specific, and its absence leads to changes in kinetochore and prophase and metaphase spindle dynamics.
Article
Physics, Multidisciplinary
Benjamin A. Dalton, David Oriola, Franziska Decker, Frank Juelicher, Jan Brugues
Summary: The study reveals the mechanism of spindle self-organization, showing that a gelation transition enables long-range microtubule transport and global coherent microtubule flows.
Article
Biochemistry & Molecular Biology
Anne Nehlig, Cynthia Seiler, Yulia Steblyanko, Florent Dingli, Guillaume Arras, Damarys Loew, Julie Welburn, Claude Prigent, Marin Barisic, Clara Nahmias
Summary: Depletion of microtubule-associated protein ATIP3 reduces metaphase spindle length by interacting with Kif2A and its partner Dda3 in an Aurora kinase A-dependent manner. The absence of ATIP3 leads to the accumulation of Kif2A and Dda3 at spindle poles, affecting poleward microtubule flux and spindle shortening. ATIP3 maintains Aurora A activity on the poles to control Kif2A targeting and spindle size, highlighting their mutual regulation in controlling spindle length.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Multidisciplinary Sciences
Michel Thiebaut de Schotten, Stephanie J. Forkel
Summary: Brain connections go beyond signal transmission and play a crucial role in behavior and cognition. They determine the brain's functional organization and contribute to understanding brain evolution and cognitive differences. Pathologies affect connections, leading to cognitive dysfunction, and the prediction of long-term symptoms is now based on brain disconnections.
Article
Multidisciplinary Sciences
Manasi Kelkar, Pierre Bohec, Matthew B. Smith, Varun Sreenivasan, Ana Lisica, Leo Valon, Emma Ferber, Buzz Baum, Guillaume Salbreux, Guillaume Charras
Summary: Proper orientation of the mitotic spindle is essential for embryo development, tissue development, and maintenance of tissue integrity and homeostasis in adults. This study used optogenetics and computational modeling to investigate how mitotic spindles respond to inhomogeneous tension within the actomyosin cortex. The results showed that the activation of RhoA at both poles of the cell influences spindle orientation by reducing pulling forces exerted by cortical regulators on astral microtubules. This perturbation of torque balance leads to spindle rotation in response to mechanical stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Felipe Mora-Bermudez, Philipp Kanis, Dominik Macak, Jula Peters, Ronald Naumann, Lei Xing, Mihail Sarov, Sylke Winkler, Christina Eugster Oegema, Christiane Haffner, Pauline Wimberger, Stephan Riesenberg, Tomislav Maricic, Wieland B. Huttner, Svante Paabo
Summary: Since the separation of modern humans from Neanderthals, around 100 amino acid substitutions have spread to almost all modern humans. Research has shown that certain modern human-specific amino acid substitutions can improve the accuracy of chromosome segregation in stem cells of the developing neocortex.
Article
Cell Biology
Tobias Kletter, Abin Biswas, Simone Reber
Summary: The article discusses the complexity of spindle construction in eukaryotic cells, as well as the dynamic interactions between spindles and the cytoplasm, emphasizing the importance of understanding microtubules and molecular collective behavior and their connection to the entire cellular environment.
CURRENT OPINION IN CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sergio Villa-Consuegra, Victor A. Tallada, Juan Jimenez
Summary: During meiosis, the localization and activity of Aurora B kinase are crucial for ensuring proper chromosome segregation. Research has shown that the relocalization activity of Aurora B kinase during meiotic interkinesis plays a key role in erasing monopolar arrangements, satisfying the spindle assembly checkpoint, and generating proper bipolar arrays.
Article
Cell Biology
Diana Papini, Mark D. Levasseur, Jonathan M. G. Higgins
Summary: Aurora B and Cyclin B-Cdk1 are crucial for stable kinetochore formation in mitosis, especially during anaphase. Despite Aurora B leaving centromeres during anaphase, a gradient of Aurora B activity centered on the central spindle continues to modulate kinetochore stability and function.
Article
Biology
Yuichi Murase, Masahiko Yamagishi, Naoyuki Okada, Mika Toya, Junichiro Yajima, Takahiro Hamada, Masamitsu Sato
Summary: Microtubule shortening is crucial for chromosome movement during cell division. In this study, the researchers demonstrated that Dis1, an ortholog of TOG/XMAP215 in fission yeast, plays a role in promoting microtubule shortening. This finding suggests an unconventional function of Dis1 in driving chromosome movement.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Patrik Risteski, Mihaela Jagric, Nenad Pavin, Iva M. Tolic
Summary: During metaphase, chromosomes align at the equatorial plane of the spindle through poleward pulling forces of kinetochore microtubules and polar ejection forces. Models include alignment mechanisms based on these forces and sliding processes dependent on mechanical coupling between microtubules.
Review
Chemistry, Multidisciplinary
N. S. Shahana Nizar, Meleppatt Sujith, K. Swathi, Cristina Sissa, Anna Painelli, K. George Thomas
Summary: This tutorial provides a comprehensive description of the origin of chiroptical properties in supramolecular and plasmonic assemblies in the UV-visible region, explaining the essential photophysical concepts for understanding chiroptical signatures. The tutorial also discusses the origins of induced circular dichroism (ICD) and exciton coupled circular dichroism (ECD) in molecular and plasmonic systems, as well as plasmonic chirality, focusing on inherent chirality, induced chirality, and surface plasmon-coupled circular dichroism (SP-CD). Additionally, it highlights the differences in oscillator strength between molecular and plasmonic systems, emphasizing the potential for intense CD signals in plasmonic systems for chiral sensing applications.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Dalia Barkley, Anjali Rao, Maayan Pour, Gustavo S. Franca, Itai Yanai
Summary: Phenotypic heterogeneity within malignant cells of a tumor is considered a key characteristic of tumorigenesis. Through single-cell transcriptomics, distinct cancer cell states have been identified, but their functional relevance and advantages to the tumor as a system remain unclear. The spectrum of cell states in a malignant population may rely on cellular lineage, epigenetic history, genetic mutations, or environmental cues, affecting the relative stability or plasticity of individual states.
Article
Reproductive Biology
Jie Zhang, Hong-Jie Yuan, Jiang Zhu, Shuai Gong, Ming-Jiu Luo, Jing-He Tan
Summary: Topoisomerase II dysfunction impairs chromatin condensation and chromosome alignment, activates Aurora B, and leads to MI arrest and PB1 abscission failure.
BIOLOGY OF REPRODUCTION
(2022)
Review
Biology
Sandeep Venkataram, Sergey Kryazhimskiy
Summary: Most species are part of ecological communities that exhibit emergent community-level properties. Understanding how these properties change over time and how member species evolution contributes to these changes is important for sustainability and human health. This review highlights the repeatability of community-level properties through evolution and discusses the challenges and open questions in quantifying this repeatability. Approaches to address these questions are outlined, emphasizing the potential for advancing our understanding of evolution and ecology and predicting eco-evolutionary dynamics.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Biophysics
Jan Arnold, Julia Mahamid, Vladan Lucic, Alex de Marco, Jose-Jesus Fernandez, Tim Laugks, Tobias Mayer, Anthony A. Hyman, Wolfgang Baumeister, Juergen M. Plitzko
BIOPHYSICAL JOURNAL
(2016)
Article
Biophysics
Jacques Pecreaux, Stefanie Redemann, Zahraa Alayan, Benjamin Mercat, Sylvain Pastezeur, Carlos Garzon-Coral, Anthony A. Hyman, Jonathon Howard
BIOPHYSICAL JOURNAL
(2016)
Article
Biophysics
Elisabeth Fischer-Friedrich, Yusuke Toyoda, Cedric J. Cattin, Daniel J. Mueller, Anthony A. Hyman, Frank Juelicher
BIOPHYSICAL JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
Elvan Boke, Martine Ruer, Martin Wuehr, Margaret Coughlin, Regis Lemaitre, Steven P. Gygi, Simon Alberti, David Drechsel, Anthony A. Hyman, Timothy J. Mitchison
Article
Biochemistry & Molecular Biology
Shambaditya Saha, Christoph A. Weber, Marco Nousch, Omar Adame-Arana, Carsten Hoege, Marco Y. Hein, Erin Osborne-Nishimura, Julia Mahamid, Marcus Jahnel, Louise Jawerth, Andrej Pozniakovski, Christian R. Eckmann, Frank Juelicher, Anthony A. Hyman
Article
Biochemistry & Molecular Biology
Elke Gabriel, Arpit Wason, Anand Ramani, Li Ming Gooi, Patrick Keller, Andrei Pozniakovsky, Ina Poser, Florian Noack, Narasimha Swamy Telugu, Federico Calegari, Tomo Saric, Juergen Hescheler, Anthony A. Hyman, Marco Gottardo, Giuliano Callaini, Fowzan Sami Alkuraya, Jay Gopalakrishnan
Article
Biochemistry & Molecular Biology
Diego Guerrera, Jimit Shah, Ekaterina Vasileva, Sophie Sluysmans, Isabelle Mean, Lionel Jond, Ina Poser, Matthias Mann, Anthony A. Hyman, Sandra Citi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Ilaria Visco, Carsten Hoege, Anthony A. Hyman, Petra Schwille
JOURNAL OF MOLECULAR BIOLOGY
(2016)
Article
Biochemical Research Methods
Susanne Hasse, Anthony A. Hyman, Mihail Sarov
Article
Multidisciplinary Sciences
Sara Cuylen, Claudia Blaukopf, Antonio Z. Politi, Thomas Mueller-Reichert, Beate Neumann, Ina Poser, Jan Ellenberg, Anthony A. Hyman, Daniel W. Gerlich
Article
Multidisciplinary Sciences
Julia Mahamid, Stefan Pfeffer, Miroslava Schaffer, Elizabeth Villa, Radostin Danev, Luis Kuhn Cuellar, Friedrich Foerster, Anthony A. Hyman, Juergen M. Plitzko, Wolfgang Baumeister
Review
Biochemistry & Molecular Biology
Jochen H. Weishaupt, Tony Hyman, Ivan Dikic
TRENDS IN MOLECULAR MEDICINE
(2016)
Article
Multidisciplinary Sciences
Xiangdong Zheng, Anand Ramani, Komal Soni, Marco Gottardo, Shuangping Zheng, Li Ming Gooi, Wenjing Li, Shan Feng, Aruljothi Mariappan, Arpit Wason, Per Widlund, Andrei Pozniakovsky, Ina Poser, Haiteng Deng, Guangshuo Ou, Maria Riparbelli, Callaini Giuliano, Anthony A. Hyman, Michael Sattler, Jay Gopalakrishnan, Haitao Li
NATURE COMMUNICATIONS
(2016)
Article
Biology
Ronald D. Vale, Anthony A. Hyman
Article
Biology
Mark Leaver, Simone Kienle, Maria L. Begasse, Ralf J. Sommer, Anthony A. Hyman
