The effect of ginsenoside Rg5, isolated from black ginseng, on heart failure in zebrafish based on untargeted metabolomics

Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis

(2020) Miao Ye et al.   JOURNAL OF NATURAL PRODUCTS

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2020) Yanyan Zhu et al.   PHARMACOLOGICAL RESEARCH

The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K

(2020) Yannan Liu et al.   Nutrients

Construction of irf4a Transgenic Zebrafish Using Tol2 System and Its Potential Application

(2020) Yawei Gou et al.   Dose-Response

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

(2020) Cuizhu Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoglycemic Effect of Ginsenoside Rg5 Mediated Partly by Modulating Gut Microbiota Dysbiosis in Diabetic db/db Mice

(2020) Yange Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High-choline diet exacerbates cardiac dysfunction, fibrosis, and inflammation in a mouse model of heart failure with preserved ejection fraction

(2020) Wei Shuai et al.   JOURNAL OF CARDIAC FAILURE

Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure

(2020) Hailian Quan et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Changes of Ginsenoside Composition in the Creation of Black Ginseng Leaf

(2020) Wei Chen et al.   MOLECULES

Ginsenoside Rg5 relieves type 2 diabetes by improving hepatic insulin resistance in db/db mice

(2020) Yange Wei et al.   Journal of Functional Foods

Neuroprotective Effects of Ginsenosides against Cerebral Ischemia

(2019) Zhekang Cheng et al.   MOLECULES

Comparative Analysis of Ginsenosides and Oligosaccharides in White Ginseng (WG), red Ginseng (RG) and Black Ginseng (BG)

(2019) Lianlian Zhu et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Captopril attenuates TAC-induced heart failure via inhibiting Wnt3a/β-catenin and Jak2/Stat3 pathways

(2019) Yu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Long non-coding RNA and mRNA analysis of Ang II-induced neuronal dysfunction

(2019) Lin-Lin Shao et al.   MOLECULAR BIOLOGY REPORTS

Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects

(2019) Ahmed M. Metwaly et al.   MOLECULES

Heart failure and healthcare informatics

(2019) Mohamed S. Anwar et al.   PLOS MEDICINE

Utilization and Dose Optimization of Angiotensin-Converting Enzyme Inhibitors among Heart Failure Patients in Southwest Ethiopia

(2019) Yirga Legesse Niriayo et al.   Biomed Research International

Identification, structure-activity relationship and in silico molecular docking analyses of five novel angiotensin I-converting enzyme (ACE)-inhibitory peptides from stone fish (Actinopyga lecanora) hydrolysates

(2019) Shehu Muhammad Auwal et al.   PLoS One

Biochemical and Metabolic Implications of Tricarboxylic Acids and their Transporters

(2019) Khalifa El-Dawy et al.   JOURNAL OF PURE AND APPLIED MICROBIOLOGY

Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer

(2019) Yannan Liu et al.   BIOCHEMICAL PHARMACOLOGY

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure

(2019) Satoshi Maekawa et al.   Cell Communication and Signaling

Greater Efficacy of Black Ginseng (CJ EnerG) over Red Ginseng against Lethal Influenza A Virus Infection

(2019) Eun-Ha Kim et al.   Nutrients

Ginsenoside-Rg5 inhibits growth and metastasis of ovarian carcinoma via suppressing expression of fibroblast growth factor-8b (FGF8b)

(2019) Hongjuan Li et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos

(2019) Jing Fu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats

(2019) Meichen Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Integrative serum metabolomics and network analysis on mechanisms exploration of Ling-Gui-Zhu-Gan Decoction on doxorubicin-induced heart failure mice

(2019) Xu Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction

(2019) Adam K. McDiarmid et al.   Journal of the American Heart Association

A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways

(2018) Fan Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In silico analysis and molecular docking study of angiotensin I-converting enzyme inhibitory peptides from smooth-hound viscera protein hydrolysates fractionated by ultrafiltration

(2018) Ola Abdelhedi et al.   FOOD CHEMISTRY

Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis

(2018) Yaru Wang et al.   MOLECULES

Developmental and metabolic responses of zebrafish ( Danio rerio ) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure

(2018) Xiaoqian Ren et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Metabolomic assessment of arsenite toxicity and novel biomarker discovery in early development of zebrafish embryos

(2018) Szu-Yuan Wu et al.   TOXICOLOGY LETTERS

A Zebrafish Heart Failure Model for Assessing Therapeutic Agents

(2018) Xiao-Yu Zhu et al.   Zebrafish

Ginsenosides Rg5 and Rk1, the skin-whitening agents in black ginseng

(2018) Yan Jin et al.   Journal of Functional Foods

Synopsis of arachidonic acid metabolism: A review

(2018) Violette Said Hanna et al.   Journal of Advanced Research

Simplified plasma essential amino acid-based profiling provides metabolic information and prognostic value additive to traditional risk factors in heart failure

(2018) Chao-Hung Wang et al.   AMINO ACIDS

The anti-inflammatory and anti-nociceptive effects of Korean black ginseng

(2018) Yuan Yee Lee et al.   PHYTOMEDICINE

Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model

(2018) Yannan Liu et al.   Food & Function

Renoprotective effect of Zhenwu decoction against renal fibrosis by regulation of oxidative damage and energy metabolism disorder

(2018) Shasha Li et al.   Scientific Reports

Design, synthesis and biological evaluation of Schiff bases of 4-amino-1,2,4-triazole derivatives as potent angiotensin converting enzyme inhibitors and antioxidant activities

(2018) Ikram Saadaoui et al.   JOURNAL OF MOLECULAR STRUCTURE

Metabolic disruption of zebrafish ( Danio rerio ) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach

(2017) Elena Ortiz-Villanueva et al.   ENVIRONMENTAL POLLUTION

Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice

(2017) Zi Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Heart failure

(2017) Marco Metra et al.   LANCET

A novel antioxidant and ACE inhibitory peptide from rice bran protein: Biochemical characterization and molecular docking study

(2017) Xiuming Wang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1

(2017) Yi-Lin Yang et al.   Cell Death & Disease

Plasma Amino Acid Abnormalities in Chronic Heart Failure. Mechanisms, Potential Risks and Targets in Human Myocardium Metabolism

(2017) Roberto Aquilani et al.   Nutrients

Improved antimicrobial effect of ginseng extract by heat transformation

(2017) Peng Xue et al.   Journal of Ginseng Research

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

Zebrafish Larvae Model of Dilated Cardiomyopathy Induced by Terfenadine

(2017) Gyojeong Gu et al.   Korean Circulation Journal

Angiotensin II induces cholesterol accumulation and injury in podocytes

(2017) Yingjie Yang et al.   Scientific Reports

High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy

(2016) Jiung-Pang Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

2016 ACC/AHA/HFSA Focused Update on New Pharmacological Therapy for Heart Failure: An Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure

(2016) Clyde W. Yancy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aliskiren, Enalapril, or Both in Heart Failure

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Black ginseng extract ameliorates hypercholesterolemia in rats

(2016) Evelyn Saba et al.   Journal of Ginseng Research

Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine–fructose

(2016) Kyung Hee Lee et al.   Journal of Ginseng Research

Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism

(2016) Chun Li et al.   Scientific Reports

Cardiac Transcriptome and Dilated Cardiomyopathy Genes in ZebrafishCLINICAL PERSPECTIVE

(2015) Yu-Huan Shih et al.   Circulation-Cardiovascular Genetics

Design and synthesis of 3-(3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)-2-phenylquinazolin-4(3H)-one derivatives to induce ACE inhibitory activity

(2015) Ramineni Venkatesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Qishenyiqi Dropping Pill attenuates myocardial fibrosis in rats by inhibiting RAAS-mediated arachidonic acid inflammation

(2015) Jing Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of White, Red and Black Ginseng on Physicochemical Properties and Ginsenosides

(2015) Yan Jin et al.   PLANT FOODS FOR HUMAN NUTRITION

Heart Failure: Advanced Development in Genetics and Epigenetics

(2015) Jian Yang et al.   Biomed Research International

Cardiac Transcriptome and Dilated Cardiomyopathy Genes in ZebrafishCLINICAL PERSPECTIVE

(2015) Yu-Huan Shih et al.   Circulation-Cardiovascular Genetics

DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4

(2014) Yong Wang et al.   BMC Complementary and Alternative Medicine

Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers

(2014) Praveen Kumar Kalavagunta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors

(2013) Dinesh Addla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

2013 ACCF/AHA Guideline for the Management of Heart Failure

(2013) Clyde W. Yancy et al.   CIRCULATION

Forecasting the Impact of Heart Failure in the United States

(2013) Paul A. Heidenreich et al.   Circulation-Heart Failure

Role of cytochrome P450–mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy

(2013) Abdulaziz M. S. Alsaad et al.   DRUG METABOLISM REVIEWS

Interaction of RAS Activation and Lipid Disorders Accelerates the Progression of Glomerulosclerosis

(2013) Kun-Ling Ma et al.   International Journal of Medical Sciences

Anti-Inflammatory Effect of Ginsenoside Rg5 in Lipopolysaccharide-Stimulated BV2 Microglial Cells

(2013) Yu Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitamin D3Therapy Corrects the Tissue Sensitivity to Angiotensin II Akin to the Action of a Converting Enzyme Inhibitor in Obese Hypertensives: An Interventional Study

(2012) Anand Vaidya et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Zebrafish Models for Human Cancer

(2012) H. R. Shive   VETERINARY PATHOLOGY

Zebrafish as a model to study cardiac development and human cardiac disease

(2011) J. Bakkers   CARDIOVASCULAR RESEARCH

A new zebrafish model for experimental leukemia therapy

(2010) Igor V. Mizgirev et al.   CANCER BIOLOGY & THERAPY

Angiotensin-converting enzymes and drug discovery in cardiovascular diseases

(2010) Lijun Shi et al.   DRUG DISCOVERY TODAY

Angiotensin I-converting enzyme (ACE) inhibitory peptides derived from arachin by simulated gastric digestion

(2010) V.K. Jimsheena et al.   FOOD CHEMISTRY

Colorimetric, High-Throughput Assay for Screening Angiotensin I-Converting Enzyme Inhibitors

(2009) V. K. Jimsheena et al.   ANALYTICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC–ELSD

(2009) Bai-Shen Sun et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Significance of the zebrafish model in the discovery of bioactive molecules from nature

(2008) Noopur Mandrekar et al.   BIOTECHNOLOGY LETTERS

Irbesartan in Patients with Heart Failure and Preserved Ejection Fraction

(2008) Barry M. Massie et al.   NEW ENGLAND JOURNAL OF MEDICINE