The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K

Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells

(2019) Nethaji Muniraj et al.   CARCINOGENESIS

Combined bazedoxifene and paclitaxel treatments inhibit cell viability, cell migration, colony formation, and tumor growth and induce apoptosis in breast cancer

(2019) Shengling Fu et al.   CANCER LETTERS

Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells

(2019) Om P.S. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Concomitant Inhibition of Cytoprotective Autophagy Augments the Efficacy of Withaferin A in Hepatocellular Carcinoma

(2019) Sumit Siddharth et al.   Cancers

Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells

(2018) Qian Wu et al.   BIOCHEMICAL PHARMACOLOGY

Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway

(2018) Jing Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PI3K/AKT signaling pathway involvement in fluoride-induced apoptosis in C2C12 cells

(2018) Bian-hua Zhou et al.   CHEMOSPHERE

Docetaxel loaded immunonanoparticles delivery in EGFR overexpressed breast carcinoma cells

(2018) Chetan Yewale et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

(2018) Lijun Jia et al.   LIFE SCIENCES

Steroid metabolism in breast cancer: Where are we and what are we missing?

(2018) Donita Africander et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1

(2018) Seung Joon Lee et al.   Journal of Functional Foods

Yulangsan polysaccharide inhibits 4T1 breast cancer cell proliferation and induces apoptosis in vitro and in vivo

(2018) Ni Qin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Co-delivery of autophagy inhibitor ATG7 siRNA and docetaxel for breast cancer treatment

(2017) Chunai Gong et al.   JOURNAL OF CONTROLLED RELEASE

Anticancer effects of ginsenoside Rk3 on non-small cell lung cancer cells: in vitro and in vivo

(2017) Zhiguang Duan et al.   Food & Function

Production of bioactive ginsenoside Rg3(S) and compound K using recombinant Lactococcus lactis

(2017) Ling Li et al.   Journal of Ginseng Research

Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells

(2017) Hyunkyung Lee et al.   Journal of Ginseng Research

Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells

(2016) Xinfeng Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer

(2016) Sherry X. Yang et al.   CANCER TREATMENT REVIEWS

BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis

(2015) C. J. Gibson et al.   CLINICAL CANCER RESEARCH

Enzymatic transformation of ginsenoside Rb1 to ginsenoside 20(S)-Rg3 by GH3 β-glucosidase from Thermotoga thermarum DSM 5069T

(2015) Jianjun Pei et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Ginsenoside-Rg5 induces apoptosis and DNA damage in human cervical cancer cells

(2014) LI-DAN LIANG et al.   Molecular Medicine Reports

Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell

(2014) Eun-Hwa Park et al.   Journal of Ginseng Research

Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3

(2014) Kyung Hoon Chang et al.   Journal of Ginseng Research

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Targeting Apoptosis Pathways for New Cancer Therapeutics

(2013) Longchuan Bai et al.   Annual Review of Medicine

MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway

(2013) Yanfei Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

(2013) Yan-Cong Li et al.   CANCER LETTERS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Med1 plays a critical role in the development of tamoxifen resistance

(2012) Arumugam Nagalingam et al.   CARCINOGENESIS

Ginsenosides from American ginseng: Chemical and pharmacological diversity

(2011) Lian-Wen Qi et al.   PHYTOCHEMISTRY

Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases

(2010) Chang-Su Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION