Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1

A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death

(2016) Z Wang et al.   Cell Death & Disease

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction

(2015) Jia Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of hexokinase in cardioprotection - mechanism and potential for translation

(2014) Andrew P Halestrap et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases

(2014) Chang Ho Lee et al.   Journal of Ginseng Research

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

(2013) Rianne Nederlof et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy

(2013) N Fillmore et al.   BRITISH JOURNAL OF PHARMACOLOGY

C-Peptide Activates AMPK  and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes

(2013) M. P. Bhatt et al.   DIABETES

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats

(2013) Ling Shen et al.   JOURNAL OF LIPID RESEARCH

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

(2013) Philippe Pasdois et al.   Journal of the American Heart Association

Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart

(2011) Jagdip S. Jaswal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Isolation and analysis of ginseng: advances and challenges

(2011) Lian-Wen Qi et al.   NATURAL PRODUCT REPORTS

Ginsenoside Rg1 Promotes Glucose Uptake Through Activated AMPK Pathway in Insulin-resistant Muscle Cells

(2011) Hye-Min Lee et al.   PHYTOTHERAPY RESEARCH

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury

(2010) Rongxue Wu et al.   CIRCULATION RESEARCH

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes

(2008) Wenbin Shang et al.   JOURNAL OF ENDOCRINOLOGY