Complementary Approaches with Free-living and Parasitic Nematodes to Understanding Anthelmintic Resistance

Recent advances in functional genomics for parasitic nematodes of mammals

(2020) Michelle L. Castelletto et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes

(2020) Spencer S. Gang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles

(2020) Clayton M. Dilks et al.   International Journal for Parasitology-Drugs and Drug Resistance

Liposome-based transfection enhances RNAi and CRISPR-mediated mutagenesis in non-model nematode systems

(2019) Sally Adams et al.   Scientific Reports

Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum

(2019) Shannon Kitchen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

(2019) Stephen R. Doyle et al.   BMC GENOMICS

A Novel Gene Underlies Bleomycin-Response Variation in Caenorhabditis elegans

(2019) Shannon C. Brady et al.   GENETICS

CRISPR/Cas9 Mutagenesis and Expression of Dominant Mutant Transgenes as Functional Genomic Approaches in Parasitic Nematodes

(2019) James B. Lok   Frontiers in Genetics

First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides

(2019) Luis Fernando Viana Furtado et al.   PLoS One

The global diversity of Haemonchus contortus is shaped by human intervention and climate

(2019) G. Sallé et al.   Nature Communications

Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?

(2019) Pablo D. Jimenez Castro et al.   Parasites & Vectors

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

(2019) Tim A Crombie et al.   eLife

Spotlight on CRISPR in Strongyloides Parasitic Nematodes

(2018) Jordan D. Ward   TRENDS IN PARASITOLOGY

Discovery of genomic intervals that underlie nematode responses to benzimidazoles

(2018) Mostafa Zamanian et al.   PLoS Neglected Tropical Diseases

Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species

(2018) Alexandra Blanchard et al.   PLoS Pathogens

Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis

(2018) Cristina Ballesteros et al.   International Journal for Parasitology-Drugs and Drug Resistance

Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana

(2018) Ambrose R. Orr et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles

(2018) Steffen R. Hahnel et al.   PLoS Pathogens

The use of nemabiome metabarcoding to explore gastro-intestinal nematode species diversity and anthelmintic treatment effectiveness in beef calves

(2017) Russell W. Avramenko et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Broad spectrum anthelmintic resistance of Haemonchus contortus in Northern NSW of Australia

(2017) Jane Lamb et al.   VETERINARY PARASITOLOGY

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

(2017) Stefan Zdraljevic et al.   PLoS Genetics

Targeted mutagenesis in a human-parasitic nematode

(2017) Spencer S. Gang et al.   PLoS Pathogens

Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren

(2017) Jürgen Krücken et al.   International Journal for Parasitology-Drugs and Drug Resistance

Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases

(2016) Mostafa Zamanian et al.   FEBS Journal

Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus

(2016) Andrew M. Rezansoff et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6years of macrocyclic lactone use

(2016) Roz Laing et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

CeNDR, theCaenorhabditis elegansnatural diversity resource

(2016) Daniel E. Cook et al.   NUCLEIC ACIDS RESEARCH

The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis.

(2015) ADRIAN J. WOLSTENHOLME et al.   PARASITOLOGY

The laboratory domestication of Caenorhabditis elegans

(2015) Mark G. Sterken et al.   TRENDS IN GENETICS

Haemonchus contortus resistance to monepantel in sheep

(2015) R. Van den Brom et al.   VETERINARY PARASITOLOGY

C. elegans outside the Petri dish

(2015) Lise Frézal et al.   eLife

Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans

(2015) I. Jana I. Janssen et al.   International Journal for Parasitology-Drugs and Drug Resistance

Exploring the Gastrointestinal “Nemabiome”: Deep Amplicon Sequencing to Quantify the Species Composition of Parasitic Nematode Communities

(2015) Russell W. Avramenko et al.   PLoS One

Novel assay for the detection and monitoring of levamisole resistance in Haemonchus contortus

(2014) Virginie Barrère et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro

(2014) Ranbir S. Sarai et al.   International Journal for Parasitology-Drugs and Drug Resistance

Exciting Prospects for Precise Engineering of Caenorhabditis elegans Genomes with CRISPR/Cas9

(2013) Christian Frøkjær-Jensen   GENETICS

Characterization and comparative analysis of the complete Haemonchus contortus β-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes

(2013) Gary Ian Saunders et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance

(2013) JOHN S. GILLEARD   PARASITOLOGY

acr-23 Encodes a Monepantel-Sensitive Channel in Caenorhabditis elegans

(2013) Lucien Rufener et al.   PLoS Pathogens

The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

(2013) Roz Laing et al.   GENOME BIOLOGY

Acetylcholine receptor subunit and P-glycoprotein transcription patterns in levamisole-susceptible and -resistant Haemonchus contortus

(2013) Ranbir S. Sarai et al.   International Journal for Parasitology-Drugs and Drug Resistance

History of Avermectin and Ivermectin, with Notes on the History of Other Macrocyclic Lactone Antiparasitic Agents

(2012) William C. Campbell   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans

(2012) R. Ghosh et al.   SCIENCE

Introgression of Ivermectin Resistance Genes into a Susceptible Haemonchus contortus Strain by Multiple Backcrossing

(2012) Elizabeth Redman et al.   PLoS Pathogens

Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance

(2011) T Boulin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus

(2011) Sally M. Williamson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Glutamate-Gated Chloride Channels of Haemonchus contortus Restore Drug Sensitivity to Ivermectin Resistant Caenorhabditis elegans

(2011) Susan K. Glendinning et al.   PLoS One

An inconvenient truth: Global worming and anthelmintic resistance

(2011) Ray M. Kaplan et al.   VETERINARY PARASITOLOGY

Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect

(2010) Lucien Rufener et al.   PLoS Pathogens

cDNA-AFLP analysis in levamisole-resistant Haemonchus contortus reveals alternative splicing in a nicotinic acetylcholine receptor subunit

(2009) Aymeric Fauvin et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The use of DNA markers to map anthelmintic resistance loci in an intraspecific cross of Haemonchus contortus

(2009) P. W. HUNT et al.   PARASITOLOGY

Gastrointestinal nematode infections in adult dairy cattle: Impact on production, diagnosis and control

(2009) Johannes Charlier et al.   VETERINARY PARASITOLOGY

Acetylcholine receptor subunit genes from Ancylostoma caninum: Altered transcription patterns associated with pyrantel resistance

(2008) Steven R. Kopp et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Prevalence of anthelmintic resistance on sheep and goat farms in the southeastern United States

(2008) Sue B. Howell et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

A new class of anthelmintics effective against drug-resistant nematodes

(2008) Ronald Kaminsky et al.   NATURE

Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor

(2008) T. Boulin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA