Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases

SapTrap, a Toolkit for High-Throughput CRISPR/Cas9 Gene Modification in Caenorhabditis elegans

(2016) M. L. Schwartz et al.   GENETICS

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Cheating evolution: engineering gene drives to manipulate the fate of wild populations

(2016) Jackson Champer et al.   NATURE REVIEWS GENETICS

Rendering the Intractable More Tractable: Tools from Caenorhabditis elegans Ripe for Import into Parasitic Nematodes

(2015) J. D. Ward   GENETICS

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

Challenges in CRISPR/CAS9 Delivery: Potential Roles of Nonviral Vectors

(2015) Ling Li et al.   HUMAN GENE THERAPY

Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans

(2015) Megan A. Sloan et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

WormBase 2016: expanding to enable helminth genomic research

(2015) Kevin L. Howe et al.   NUCLEIC ACIDS RESEARCH

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A male-determining factor in the mosquito Aedes aegypti

(2015) A. B. Hall et al.   SCIENCE

The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations

(2015) V. M. Gantz et al.   SCIENCE

Caenorhabditis elegans is a useful model for anthelmintic discovery

(2015) Andrew R. Burns et al.   Nature Communications

A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains

(2015) Erik C. Andersen et al.   G3-Genes Genomes Genetics

Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi

(2015) Mostafa Zamanian et al.   PLoS Neglected Tropical Diseases

Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening

(2015) Wenjing Law et al.   PLoS Pathogens

Exome and Transcriptome Sequencing of Aedes aegypti Identifies a Locus That Confers Resistance to Brugia malayi and Alters the Immune Response

(2015) Punita Juneja et al.   PLoS Pathogens

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation

(2015) X. Han et al.   Science Advances

Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system

(2014) Pengpeng Liu et al.   CELL RESEARCH

A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans

(2014) Heesun Kim et al.   GENETICS

Efficient Marker-Free Recovery of Custom Genetic Modifications with CRISPR/Cas9 in Caenorhabditis elegans

(2014) J. A. Arribere et al.   GENETICS

The Brugia malayi neuropeptide receptor-4 is activated by FMRFamide-like peptides and signals via Gαi

(2014) Ross C. Anderson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

Heritable strategies for controlling insect vectors of disease

(2014) A. Burt   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulating gene drives

(2014) K. A. Oye et al.   SCIENCE

A synthetic sex ratio distortion system for the control of the human malaria mosquito

(2014) Roberto Galizi et al.   Nature Communications

Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells

(2014) Ignazio Maggio et al.   Scientific Reports

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Assembly of the Genome of the Disease Vector Aedes aegypti onto a Genetic Linkage Map Allows Mapping of Genes Affecting Disease Transmission

(2014) Punita Juneja et al.   PLoS Neglected Tropical Diseases

Global Programme to Eliminate Lymphatic Filariasis: The Processes Underlying Programme Success

(2014) Kazuyo Ichimori et al.   PLoS Neglected Tropical Diseases

Dual RNA-seq of Parasite and Host Reveals Gene Expression Dynamics during Filarial Worm–Mosquito Interactions

(2014) Young-Jun Choi et al.   PLoS Neglected Tropical Diseases

Concerning RNA-guided gene drives for the alteration of wild populations

(2014) Kevin M Esvelt et al.   eLife

Enzymology of the nematode cuticle: A potential drug target?

(2014) Antony P. Page et al.   International Journal for Parasitology-Drugs and Drug Resistance

Infection barriers and responses in mosquito–filarial worm interactions

(2014) Lyric C Bartholomay   Current Opinion in Insect Science

Toward the elimination of lymphatic filariasis by 2020: treatment update and impact assessment for the endgame

(2013) Maria P Rebollo et al.   Expert Review of Anti-Infective Therapy

Helminth therapies: Translating the unknown unknowns to known knowns

(2013) Adnan R. Khan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The dauer hypothesis and the evolution of parasitism: 20years on and still going strong

(2013) Matt Crook   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

Heritable genome editing in C. elegans via a CRISPR-Cas9 system

(2013) Ari E Friedland et al.   NATURE METHODS

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Polyethyleneimine Mediated DNA Transfection in Schistosome Parasites and Regulation of the WNT Signaling Pathway by a Dominant-Negative SmMef2

(2013) Shuang Liang et al.   PLoS Neglected Tropical Diseases

Elimination and Eradication of Neglected Tropical Diseases with Mass Drug Administrations: A Survey of Experts

(2013) Jeremy D. Keenan et al.   PLoS Neglected Tropical Diseases

NTDs V.2.0: “Blue Marble Health”—Neglected Tropical Disease Control and Elimination in a Shifting Health Policy Landscape

(2013) Peter J. Hotez   PLoS Neglected Tropical Diseases

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity

(2012) Erik C Andersen et al.   NATURE GENETICS

An image analysis toolbox for high-throughput C. elegans assays

(2012) Carolina Wählby et al.   NATURE METHODS

Efficient in vitro RNA interference and immunofluorescence-based phenotype analysis in a human parasitic nematode, Brugia malayi

(2012) Frédéric Landmann et al.   Parasites & Vectors

DNA Display Selection of Peptide Ligands for a Full-Length Human G Protein-Coupled Receptor on CHO-K1 Cells

(2012) Nobuhide Doi et al.   PLoS One

In vitro selection of a peptide antagonist of growth hormone secretagogue receptor using cDNA display

(2012) S. Ueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development

(2012) A. T. Isaacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

(2012) G. Gasiunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans

(2012) R. Ghosh et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

In Vitro Silencing of Brugia malayi Trehalose-6-Phosphate Phosphatase Impairs Embryogenesis and In Vivo Development of Infective Larvae in Jirds

(2012) Susheela Kushwaha et al.   PLoS Neglected Tropical Diseases

A Research Agenda for Helminth Diseases of Humans: Intervention for Control and Elimination

(2012) Roger K. Prichard et al.   PLoS Neglected Tropical Diseases

A Research Agenda for Helminth Diseases of Humans: Diagnostics for Control and Elimination Programmes

(2012) James S. McCarthy et al.   PLoS Neglected Tropical Diseases

Transposon-mediated Chromosomal Integration of Transgenes in the Parasitic Nematode Strongyloides ratti and Establishment of Stable Transgenic Lines

(2012) Hongguang Shao et al.   PLoS Pathogens

A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia

(2012) Laura R. Serbus et al.   PLoS Pathogens

RNAi in Arthropods: Insight into the Machinery and Applications for Understanding the Pathogen-Vector Interface

(2012) Annette-Christi Barnard et al.   Genes

RNAi mediated silencing of ATPase RNA helicase gene in adult filarial parasite Brugia malayi impairs in vitro microfilaria release and adult parasite viability

(2011) Meghna Singh et al.   JOURNAL OF BIOTECHNOLOGY

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

(2011) Nikolai Windbichler et al.   NATURE

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

mRNA display for the selection and evolution of enzymes from in vitro-translated protein libraries

(2011) Burckhard Seelig   Nature Protocols

Glutamate-Gated Chloride Channels of Haemonchus contortus Restore Drug Sensitivity to Ivermectin Resistant Caenorhabditis elegans

(2011) Susan K. Glendinning et al.   PLoS One

Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells

(2011) Raphaël Duvoisin et al.   TRANSGENIC RESEARCH

An inconvenient truth: Global worming and anthelmintic resistance

(2011) Ray M. Kaplan et al.   VETERINARY PARASITOLOGY

The NIH-NIAID Filariasis Research Reagent Resource Center

(2011) Michelle L. Michalski et al.   PLoS Neglected Tropical Diseases

RNAi Effector Diversity in Nematodes

(2011) Johnathan J. Dalzell et al.   PLoS Neglected Tropical Diseases

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

(2011) Mike Y. Osei-Atweneboana et al.   PLoS Neglected Tropical Diseases

Engineered Resistance to Plasmodium falciparum Development in Transgenic Anopheles stephensi

(2011) Alison T. Isaacs et al.   PLoS Pathogens

In vivo transfection of developmentally competent Brugia malayi infective larvae

(2010) Shulin Xu et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Stunting and soil-transmitted-helminth infections among school-age pupils in rural areas of southern China

(2010) Yu Shang et al.   Parasites & Vectors

Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi

(2010) Y. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of an In Vivo RNAi Protocol to Investigate Gene Function in the Filarial Nematode, Brugia malayi

(2010) Chuanzhe Song et al.   PLoS Pathogens

Selfish DNA: Homing Endonucleases Find a Home

(2009) David R. Edgell   CURRENT BIOLOGY

Identification of an Ascaris G protein-coupled acetylcholine receptor with atypical muscarinic pharmacology

(2009) Michael J. Kimber et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

(2009) T. S. Churcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brugia malayi Excreted/Secreted Proteins at the Host/Parasite Interface: Stage- and Gender-Specific Proteomic Profiling

(2009) Sasisekhar Bennuru et al.   PLoS Neglected Tropical Diseases

Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor

(2008) T. Boulin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE

Sampling strategies to detect anthelmintic resistance: the perspective of human onchocerciasis

(2008) Thomas S. Churcher et al.   TRENDS IN PARASITOLOGY

Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products

(2008) Yovany Moreno et al.   PLoS Neglected Tropical Diseases

CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea

(2007) Rotem Sorek et al.   NATURE REVIEWS MICROBIOLOGY

Phage display: a useful tool for malaria research?

(2007) Roberto Lanzillotti et al.   TRENDS IN PARASITOLOGY