A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion

(2020) Nobukazu Miyamoto et al.   GLIA

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells

(2019) S. Yasmeen et al.   MOLECULAR NEUROBIOLOGY

Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI

(2019) Sunil Koundal et al.   NEUROSCIENCE

Refinement of a chronic cranial window implant in the rat for longitudinal in vivo two–photon fluorescence microscopy of neurovascular function

(2019) Margaret M. Koletar et al.   Scientific Reports

Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

(2019) Sarah McGrory et al.   Scientific Reports

Association Between Endothelial Cell Stabilizing Medication and Small Vessel Disease Stroke: A Case-Control Study

(2019) Charlotte Elisabeth Becker et al.   Frontiers in Neurology

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Visualization and Quantification of Post-stroke Neural Connectivity and Neuroinflammation Using Serial Two-Photon Tomography in the Whole Mouse Brain

(2019) Katherine Poinsatte et al.   Frontiers in Neuroscience

Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL

(2019) Rikesh M. Rajani et al.   Acta Neuropathologica Communications

Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke

(2018) Julien Ratelade et al.   JOURNAL OF PATHOLOGY

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Cerebral small vessel disease: from a focal to a global perspective

(2018) Annemieke ter Telgte et al.   Nature Reviews Neurology

Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: In vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure

(2018) Mohammad A. Kaisar et al.   NEUROSCIENCE LETTERS

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2depletion

(2018) Osama F. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

(2018) Rikesh M. Rajani et al.   Science Translational Medicine

High Circulatory Phosphate Level Is Associated with Cerebral Small-Vessel Diseases

(2018) Chih-Ping Chung et al.   Translational Stroke Research

A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology

(2018) Catherine A Humphreys et al.   International Journal of Stroke

Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues

(2018) Jiao Wang et al.   Scientific Reports

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

(2018) Osama F Harraz et al.   eLife

Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension

(2017) Felipe Freitas et al.   MICROCIRCULATION

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

COL4A2 is associated with lacunar ischemic stroke and deep ICH

(2017) Kristiina Rannikmäe et al.   NEUROLOGY

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

(2017) Antje Appelt-Menzel et al.   Stem Cell Reports

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

(2017) Akihiro Kitamura et al.   Scientific Reports

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cathepsin A–related arteriopathy with strokes and leukoencephalopathy (CARASAL)

(2016) Marianna Bugiani et al.   NEUROLOGY

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

(2016) Yorito Hattori et al.   Journal of the American Heart Association

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

Experimental model of small subcortical infarcts in mice with long-lasting functional disabilities

(2015) Hiroki Uchida et al.   BRAIN RESEARCH

Simvastatin Restored Vascular Reactivity, Endothelial Function and Reduced String Vessel Pathology in a Mouse Model of Cerebrovascular Disease

(2015) Xin-Kang Tong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gliovascular Disruption and Cognitive Deficits in a Mouse Model with Features of Small Vessel Disease

(2015) Philip R Holland et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review

(2015) Anna Poggesi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HANAC Syndrome Col4a1 Mutation Causes Neonate Glomerular Hyperpermeability and Adult Glomerulocystic Kidney Disease

(2015) Z. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

(2015) Xing-Lin Tan et al.   Molecular Neurodegeneration

White matter hyperintensities and normal-appearing white matter integrity in the aging brain

(2015) Susana Muñoz Maniega et al.   NEUROBIOLOGY OF AGING

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease

(2015) Fabrice Dabertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

What are White Matter Hyperintensities Made of? Relevance to Vascular Cognitive Impairment

(2015) Joanna M. Wardlaw et al.   Journal of the American Heart Association

Aquaporin 4-Dependent expression of glial fibrillary acidic protein and tenascin-C in activated astrocytes in stab wound mouse brain and in primary culture

(2014) Hiroko Ikeshima-Kataoka et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities

(2014) J. M. Wardlaw et al.   NEUROLOGY

Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes

(2014) Julie Boyer-Di Ponio et al.   PLoS One

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

(2014) Nathalie Beaufort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral Small Vessel Disease

(2014) Anne Joutel et al.   STROKE

Assessment of behavioral flexibility after middle cerebral artery occlusion in mice

(2013) Jérôme Linden et al.   BEHAVIOURAL BRAIN RESEARCH

Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL

(2013) Marie Monet-Leprêtre et al.   BRAIN

Circulating Markers of Endothelial Dysfunction and Platelet Activation in Patients with Severe Symptomatic Cerebral Small Vessel Disease

(2013) Philippa C. Lavallée et al.   CEREBROVASCULAR DISEASES

Cerebral and Extracerebral Vasoreactivity in Symptomatic Lacunar Stroke Patients: A Case-Control Study

(2013) Dominique Deplanque et al.   International Journal of Stroke

Linking endothelial dysfunction with endothelial cell activation

(2013) James K. Liao   JOURNAL OF CLINICAL INVESTIGATION

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

COL4A2 mutation associated with familial porencephaly and small-vessel disease

(2012) Elly Verbeek et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Deficits in auditory, cognitive, and motor processing following reversible middle cerebral artery occlusion in mice

(2012) Dongnhu T. Truong et al.   EXPERIMENTAL NEUROLOGY

COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets

(2012) D. S. Kuo et al.   HUMAN MOLECULAR GENETICS

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

(2012) Eduard Urich et al.   PLoS One

Myelin Loss Associated With Neuroinflammation in Hypertensive Rats

(2012) Fakhreya Y. Jalal et al.   STROKE

Notch3 Arg170Cys Knock-In Mice Display Pathologic and Clinical Features of the Neurovascular Disorder Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

(2011) Goedele Wallays et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High Temperature Requirement Factor A1 (HTRA1) Gene Regulates Angiogenesis through Transforming Growth Factor-β Family Member Growth Differentiation Factor 6

(2011) Li Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Disruption of Axon-Glial Integrity in Response to Mild Cerebral Hypoperfusion

(2011) M. M. Reimer et al.   JOURNAL OF NEUROSCIENCE

Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

(2011) E. L. Bailey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

(2011) K. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular pathology in the aged human brain

(2010) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

Permeability of Endothelial and Astrocyte Cocultures: In Vitro Blood–Brain Barrier Models for Drug Delivery Studies

(2010) Guanglei Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume

(2010) Tom Van Agtmael et al.   HUMAN MOLECULAR GENETICS

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Is endothelial dysfunction of cerebral small vessel responsible for white matter lesions after chronic cerebral hypoperfusion in rats?

(2010) Yonghua Huang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Biomarkers of Endothelial Cell Activation Serve as Potential Surrogate Markers for Drug-induced Vascular Injury

(2010) Jun Zhang et al.   TOXICOLOGIC PATHOLOGY

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

Potential Animal Models of Lacunar Stroke

(2009) Emma L. Bailey et al.   STROKE

HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis

(2008) Veela B. Mehta et al.   GROWTH FACTORS

Do in vivo Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review

(2008) Atticus H Hainsworth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL