Distinct modes of cell competition shape mammalian tissue morphogenesis

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition

(2018) Chang-Hyun Lee et al.   DEVELOPMENTAL CELL

Correction of aberrant growth preserves tissue homeostasis

(2017) Samara Brown et al.   NATURE

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

(2017) Shunsuke Kon et al.   NATURE CELL BIOLOGY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Coupling organelle inheritance with mitosis to balance growth and differentiation

(2017) Amma Asare et al.   SCIENCE

Spatial constraints govern competition of mutant clones in human epidermis

(2017) M. D. Lynch et al.   Nature Communications

Cell Competition: Mechanisms and Physiological Roles

(2016) Cristina Clavería et al.   Annual Review of Cell and Developmental Biology

WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation

(2016) Tamara Ouspenskaia et al.   CELL

Cell Competition and Its Role in the Regulation of Cell Fitness from Development to Cancer

(2016) Aida Di Gregorio et al.   DEVELOPMENTAL CELL

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Elimination of Unfit Cells Maintains Tissue Health and Prolongs Lifespan

(2015) Marisa M. Merino et al.   CELL

Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool

(2015) Kailin R. Mesa et al.   NATURE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo

(2014) M. Amoyel et al.   EMBO JOURNAL

Cell competition is a tumour suppressor mechanism in the thymus

(2014) Vera C. Martins et al.   NATURE

Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN

(2014) Scott E. Williams et al.   NATURE CELL BIOLOGY

Coordinate Regulation of Stem Cell Competition by Slit-Robo and JAK-STAT Signaling in the Drosophila Testis

(2014) Rachel R. Stine et al.   PLoS Genetics

Competitive Interactions Eliminate Unfit Embryonic Stem Cells at the Onset of Differentiation

(2013) Margarida Sancho et al.   DEVELOPMENTAL CELL

Myc-driven endogenous cell competition in the early mammalian embryo

(2013) Cristina Clavería et al.   NATURE

Accounting for technical noise in single-cell RNA-seq experiments

(2013) Philip Brennecke et al.   NATURE METHODS

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

(2010) Slobodan Beronja et al.   NATURE MEDICINE

Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche

(2009) C. Rhiner et al.   DEVELOPMENT