Extended regorafenib treatment can be linked with mitochondrial damage leading to cardiotoxicity

Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions

(2019) Maurizio Forte et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regorefenib induces extrinsic/intrinsic apoptosis and inhibits MAPK/NF-κB-modulated tumor progression in bladder cancer in vitro and in vivo

(2019) Chih-Hung Chiang et al.   ENVIRONMENTAL TOXICOLOGY

3′-Deoxy-3’-18F-Fluorothymidine and 18F-Fluorodeoxyglucose positron emission tomography for the early prediction of response to Regorafenib in patients with metastatic colorectal cancer refractory to all standard therapies

(2019) Jeong Eun Kim et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo

(2019) Po-Jung Pan et al.   Journal of Clinical Medicine

Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo

(2019) Mao-Chi Weng et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial uncoupling, ROS generation and cardioprotection

(2018) Susana Cadenas   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

(2018) Franziska Paech et al.   TOXICOLOGY

Tyrosine Kinase Inhibitor-Induced Hypertension

(2018) Megha Agarwal et al.   Current Oncology Reports

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

(2018) Massimo Bonora et al.   Nature Reviews Cardiology

Mechanisms, monitoring, and management of tyrosine kinase inhibitors-associated cardiovascular toxicities

(2018) Maher Chaar et al.   OncoTargets and Therapy

Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency

(2018) Guilhian Leipnitz et al.   Scientific Reports

Association between mitochondrial DNA copy number and cardiovascular disease: Current evidence based on a systematic review and meta-analysis

(2018) Peng Yue et al.   PLoS One

Regorafenib reverses HGF-induced sorafenib resistance by inhibiting epithelial-mesenchymal transition in hepatocellular carcinoma

(2018) Weibo Chen et al.   FEBS Open Bio

Hypertension, left ventricular hypertrophy, and sudden cardiac death

(2017) Mohammad Shenasa et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines

(2017) Cécile Mingard et al.   JOURNAL OF APPLIED TOXICOLOGY

Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

(2017) David Sebastián et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function

(2017) Julia I-Ju Leu et al.   Oncotarget

Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

(2016) Jun Zhang et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure

(2016) Rob C.I. Wüst et al.   CARDIOVASCULAR RESEARCH

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

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(2015) Autumn Tocchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy

(2015) Eric I. Marks et al.   CANCER BIOLOGY & THERAPY

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

Regorafenib: A Review of Its Use in Patients with Advanced Gastrointestinal Stromal Tumours

(2015) Matt Shirley et al.   DRUGS

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

(2015) Sang-Bing Ong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

(2015) Erdi Sozen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis

(2015) Zuquan Weng et al.   TOXICOLOGY

Localization and expression of heat shock protein 70 with rat myocardial cell damage induced by heat stress in vitro and in vivo

(2014) HONGBO CHEN et al.   Molecular Medicine Reports

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on Cardiac Repolarisation (QT Interval)

(2013) Rashmi R. Shah et al.   DRUG SAFETY

Prevention and management of adverse events related to regorafenib

(2013) Mieke De Wit et al.   SUPPORTIVE CARE IN CANCER

Proteolytic control of mitochondrial function and morphogenesis

(2012) Ruchika Anand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regorafenib for patients with previously untreated metastatic or unresectable renal-cell carcinoma: a single-group phase 2 trial

(2012) Tim Eisen et al.   LANCET ONCOLOGY

Mitochondrial network in the heart

(2012) Qian Li et al.   Protein & Cell

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats

(2011) Huiyin Tu et al.   JOURNAL OF NEUROPHYSIOLOGY

Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism

(2011) Sabrina Diano et al.   TRENDS IN MOLECULAR MEDICINE

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

(2010) Scott M. Wilhelm et al.   INTERNATIONAL JOURNAL OF CANCER

Why do Kinase Inhibitors Cause Cardiotoxicity and What can be Done About It?

(2010) Hui Cheng et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Differences in Effects on Myocardium and Mitochondria by Angiogenic Inhibitors Suggest Separate Mechanisms of Cardiotoxicity

(2010) Kevin J. French et al.   TOXICOLOGIC PATHOLOGY

Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer

(2010) Howard R. Mellor et al.   TOXICOLOGICAL SCIENCES

Mitochondrial OPA1, apoptosis, and heart failure

(2009) Le Chen et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Lon protease is a human stress protein

(2009) Jenny K. Ngo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein Quality Control in Mitochondria

(2009) T. Tatsuta   JOURNAL OF BIOCHEMISTRY

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION