Article
Biochemistry & Molecular Biology
Deepu Sharma, Fayyaz Rasool, Manjri Bharti, Komal M. Vyas, Sri Krishna Jayadev Magani
Summary: Cancer is a major cause of death worldwide, with colorectal cancer being the third most common type. Kinases play a critical role in the development of colorectal cancer, and multi-kinase inhibitors are used as a therapeutic strategy. Ruthenium-based compounds have shown potential as alternatives to platinum-based drugs. This study evaluated the activity of Ru-1, a ruthenium-based compound, alone and in combination with regorafenib against regorafenib-resistant colorectal cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jun Zhao, Boyu Pan, Xinglu Zhou, Chunnuan Wu, Fengcheng Hao, Jie Zhang, Liren Liu
Summary: This study evaluated the pharmacological activity of polygonum cuspidatum (a Chinese herb) using network pharmacology and bioinformatic tools. The results showed that polygonum cuspidatum has a potential therapeutic effect on osteosarcoma (OS) and may exert its effects on the cell cycle and apoptosis of OS cells through inhibiting Akt/ERK/EGFR pathways. The findings provide a novel insight into the discovery of CHM-based drugs against malignancies.
Article
Cell Biology
Zhen Huang, Shenglin Wang, Hongxiang Wei, Hui Chen, Rongkai Shen, Renqin Lin, Xinwen Wang, Wenbin Lan, Rongjin Lin, Jianhua Lin
Summary: BUB1 is overexpressed in osteosarcoma and closely associated with poor clinical outcomes. Inhibition of BUB1 significantly suppresses cell proliferation and tumor growth, cell migration, invasion, and induces apoptosis in osteosarcoma by blocking the PI3K/Akt and ERK signaling pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kelsie J. Anson, Giulia A. Corbet, Amy E. Palmer
Summary: In this study, the researchers investigated how changes in intracellular zinc ion levels affect kinase signaling pathways using fluorescent biosensors and cell perturbations. The results showed that zinc ion fluctuations are not toxic and do not activate stress-dependent kinase signaling. Additionally, the study demonstrated that while zinc ions can inhibit phosphatases, ERK and Akt are primarily activated through upstream signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Zhenyu Cao, Jianwu Ma, Xiaozhong Shen
Summary: Alpinetin has potential therapeutic effects on osteosarcoma through inhibiting cell proliferation, promoting apoptosis, and inhibiting cell metastasis by inactivating the PI3K/AKT and ERK signaling pathways.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2022)
Article
Biochemistry & Molecular Biology
Zhaozhou Ren, Wan'an Xiao, Ming He, Lunhao Bai
Summary: This study reveals that chitosan binds with the PI3K p85 subunit to suppress the activity of the PI3K/Akt pathway, upregulating the expression of FAM172A, and exerting its inhibitory effect on osteosarcoma growth by suppressing the phosphorylation of MEK1/2 and blocking the activity of the MAPK/ERK signaling pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Multidisciplinary Sciences
Hao Yan, Wentong Wu, Yuhuai Hu, Jinjin Li, Jiangxin Xu, Xueqin Chen, Zhifei Xu, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo
Summary: It is shown that regorafenib inhibits the phosphorylation of EphA2 at Ser897, leading to the accumulation of p53 and the development of hepatotoxicity. Inhibition of EphA2 Ser897 phosphorylation may be the key mechanism underlying regorafenib-induced liver injury.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Yubo Xiang, Yingxin Yang, Jia Liu, Xu Yang
Summary: Osteosarcoma is a primary malignant bone tumor that mainly affects children and adolescents, and it is often associated with overactivation of the PI3K/AKT pathway. MicroRNAs (miRNAs) are small RNA molecules that play a role in gene regulation, and they are involved in the PI3K/AKT pathway and the development of osteosarcoma. MiRNAs can influence various cellular functions by targeting the PI3K/AKT pathway and regulating the expression of osteosarcoma-related genes. Additionally, miRNAs associated with the PI3K/AKT pathway have potential as biomarkers for osteosarcoma diagnosis, treatment, and prognosis assessment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Chen
Summary: In this study, it was found that REGO induces apoptosis through the PI3K/AKT/FOXO3a/Bim-mediated intrinsic pathway. REGO downregulates PI3K and p-AKT level, preventing FOXO3a nuclear export and promoting Bim expression and translocation into mitochondria. Knockdown experiments confirm the crucial role of Bim and Bax/Bak in REGO-induced apoptosis.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Yong Cui, Yong-Yong Dong
Summary: Researchers have found that ZCCHC12 is highly upregulated in osteosarcoma cells, promoting cell proliferation, tumor growth, migration, and epithelial-mesenchymal transition. In addition, ZCCHC12 exerts its oncogenic function in osteosarcoma cells by activating the PI3K/AKT pathway. Inhibition of this pathway limits the oncogenic function of ZCCHC12 in osteosarcoma cells.
Article
Cell Biology
Kezhou Xia, Di Zheng, Zhun Wei, Wenda Liu, Weichun Guo
Summary: Recent studies have shown that TRIM26 gene is downregulated in osteosarcoma and higher expression of TRIM26 is associated with better prognosis. Overexpression of TRIM26 can promote the degradation of RACK1, leading to inactivation of MEK/ERK signaling and inhibition of osteosarcoma proliferation and invasion.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Liangyu Guo, Kangwen Xiao, Yuanlong Xie, Zhiqiang Yang, Jun Lei, Lin Cai
Summary: This study validated the effect of HSPB6 on osteosarcoma through experiments and found that HSPB6 overexpression can inhibit cell proliferation, increase apoptosis, reduce cell migration and invasion in osteosarcoma. These effects are mediated through the ERK signaling pathway.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Paolo Armando Gagliardi, Maciej Dobrzynski, Marc-Antoine Jacques, Coralie Dessauges, Pascal Ender, Yannick Blum, Robert M. Hughes, Andrew R. Cohen, Olivier Pertz
Summary: Cell death events are essential for eliminating old or damaged cells, but how apoptotic events are organized spatially and temporally to maintain epithelial homeostasis is still unclear. Research has shown that waves of ERK/Akt activity pulses originating from apoptotic cells can act as spatial survival signals, protecting nearby cells from apoptosis for a period of 3-4 hours. At the population level, these waves help maintain epithelial homeostasis in response to environmental insults.
DEVELOPMENTAL CELL
(2021)
Article
Cell & Tissue Engineering
Mingjia Zhang, Xuechun Li, Wenjing Wu, Jingxi Gao, Qin Han, Zhao Sun, Robert Chunhua Zhao
Summary: Regorafenib inhibits proliferation and induces apoptosis of gastrointestinal cancer-associated fibroblasts (CAFs) by suppressing the phosphorylation of AKT. It also affects macrophage infiltration in tumor tissues by reducing the proportion of CAFs.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Oncology
Songjia Ni, Jianjun Li, Sujun Qiu, Yingming Xie, Kaiqin Gong, Yang Duan
Summary: The study revealed that KIF21B is upregulated in osteosarcoma and may regulate the proliferation and apoptosis of osteosarcoma cells through the PI3K/AKT pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yueh-Shan Weng, I-Tsang Chiang, Jai-Jen Tsai, Yu-Chang Liu, Fei-Ting Hsu
Summary: This study suggests that lenvatinib can enhance the anti-hepatocellular carcinoma (HCC) efficacy of radiation therapy (RT) by inhibiting Src/STAT3/NF-KB signaling. The findings reveal the role of targeting Src and its regulation of epithelial-mesenchymal transition (EMT) in increasing the sensitivity of HCC to radiation. Lenvatinib and sorafenib, both multikinase inhibitors, are effective in treating HCC.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Medicine, Research & Experimental
Li-Cho Hsu, Chen-Yu Kuo, Fei -Ting Hsu, Hsin Feng Chang, Jing-Jim Ou
Summary: This study found that hyperforin, an active constituent from Hypericum perforatum, suppresses the progression and transformation of colorectal cancer (CRC) by inhibiting the JAK/STAT3, ERK, and AKT signaling pathways, suggesting its therapeutic potential.
Article
Oncology
Wei-Ting Chen, Yuan-Hsin Tsai, Peggy Tan, Fei-Ting Hsu, Hui-Min David Wang, Wei-Chin Lin, Feng-Huei Lin, Ching-Te Wu
Summary: Osteosarcoma is a common bone malignancy with high metastatic characteristics and poor prognosis. Fluoxetine, an anti-depressant, has been shown to have antitumor potential. In this study, fluoxetine was found to induce cytotoxicity and apoptosis in osteosarcoma cells, while also suppressing metastasis and angiogenesis by targeting STAT3.
ANTICANCER RESEARCH
(2023)
Article
Cell Biology
Yu-Chang Liu, Cheng Hsun Lin, Kuan-Tin Chen, De-Wei Lai, Fei-Ting Hsu
Summary: Hepatocellular carcinoma (HCC) is a common cancer in Asian population and is relatively insensitive to radiotherapy (RT). Epidermal growth factor receptor (EGFR)-mediated signalling plays a crucial role in HCC treatment efficacy. 18beta-glycyrrhetinic acid (18 beta-GA) has anti-tumor effects, but its ability to sensitize HCC to RT is unclear. This study used RNA data to analyze the relationship between EGFR/ERK/nuclear factor kappa B (NF-kappa B) signalling and RT and found that NF-kappa B activation may lead to RT resistance in HCC. Combining 18 beta-GA with RT enhanced RT efficacy in a Hep3B-bearing animal model. 18 beta-GA acts as a radiosensitizer by inhibiting EGFR-mediated HCC progression and inducing caspase-dependent apoptosis signalling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Che-Jui Yang, Zhao-Lin Tan, Jr-Di Yang, Fei-Ting Hsu, Chih-Hung Chiang
Summary: Bladder cancer, a common cancer type with poor prognosis, can be divided into MIBC and NMIBC. In this study, the efficacy of fluoxetine, an antidepressant, on BC was investigated. The results showed that fluoxetine induced cytotoxicity, apoptosis, and inhibited invasion and migration in BC cells. Fluoxetine also inactivated the phosphorylation of STAT3 and NF-cB and suppressed their nuclear translocation. In MB49-bearing mice, fluoxetine effectively delayed the progression of BC without inducing toxicity. Overall, fluoxetine targets STAT3 and NF-cB-mediated signaling to inhibit BC progression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Letter
Oncology
Yueh-Shan Weng, I-Tsang Chiang, Jai-Jen Tsai, Yu-Chang Liu, Fei-Ting Hsu
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Meeting Abstract
Oncology
Po-Fu Yueh, Yuan Chang, Keng-Li Lan, Fei-Ting Hsu
Meeting Abstract
Oncology
Peggy Tan, Jai-Jen Tsai, Fei-Ting Hsu, Yu-Chiang Liu
Meeting Abstract
Oncology
Kai-Jen Pai, I-Tsang Chiang, Fei-Ting Hsu, Jai-Jen Tsai
Meeting Abstract
Oncology
Tsal-Lan Liao, I-Tsang Chiang, Yuan Chang, Fei-Ting Hsu
Meeting Abstract
Oncology
Tsai Lin Lo, Jai-Jen Tsai, Fei-Ting Hsu, Yuan Chang
Meeting Abstract
Oncology
Ying-Tzu Chen, I-Tsang Chiang, Yuan Chang, Fei-Ting Hsu
Article
Biochemistry & Molecular Biology
Hsu-Shan Huang, I-Tsang Chiang, Bashir Lawal, Yueh-Shan Weng, Long-Bin Jeng, Yu-Cheng Kuo, Yu-Chang Liu, Fei-Ting Hsu
Summary: A newly developed drug called CC12 has been found to effectively penetrate the blood-brain barrier and possess anti-GBM capacity. It initiates apoptotic mechanisms and disrupts LYN/ERK/STAT3/NF-KB-regulated GBM progression, inhibiting tumor growth and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yu-Ching Li, Chui-Na Wong, Fei-Ting Hsu, Jiann-Hwa Chen, Chung-Chi Yang, Heng-Hao Liu, Wei-Lung Chen, Yueh-Shan Weng
Summary: In this study, it was found that magnolol extract from the bark of Magnolia officinalis significantly induced cytotoxicity and apoptosis in TNBC cell lines. It also decreased metastasis and inhibited the EGFR/JAK/STAT3 signaling pathway. Thus, magnolol has the potential to serve as a treatment for TNBC.
