The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy

Destruction in maternal-fetal interface of URSA patients via the increase of the HMGB1-RAGE/TLR2/TLR4-NF-κB signaling pathway

(2020) Huijuan Zou et al.   LIFE SCIENCES

Inhibition of HMGB1 improves necrotizing enterocolitis by inhibiting NLRP3 via TLR4 and NF-κB signaling pathways

(2019) Renqiang Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner

(2019) Ashley M. Cowie et al.   PAIN

Glycyrrhizin attenuates hepatic ischemia-reperfusion injury by suppressing HMGB1-dependent GSDMD-mediated kupffer cells pyroptosis

(2019) Shuyao Hua et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

The relevance of pyroptosis in the pathogenesis of liver diseases

(2019) Huiting Guo et al.   LIFE SCIENCES

In Vitro Anti-Inflammatory Effects of Phenolic Compounds from Moraiolo Virgin Olive Oil (MVOO) in Brain Cells via Regulating the TLR4/NLRP3 Axis

(2019) Agnese Taticchi et al.   MOLECULES

Rapamycin Protects Skin Fibroblasts from Ultraviolet B-Induced Photoaging by Suppressing the Production of Reactive Oxygen Species

(2018) Dengke Qin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway

(2018) Zhiqiang Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

(2018) Elena Khanova et al.   HEPATOLOGY

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome

(2018) Zhaohui Liu et al.   INFLAMMATION

Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

(2018) Juliane I. Beier et al.   JOURNAL OF HEPATOLOGY

Neuroprotective Effect of Artesunate in Experimental Model of Traumatic Brain Injury

(2018) Enrico Gugliandolo et al.   Frontiers in Neurology

Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice

(2018) Cheng Cheng et al.   BIOSCIENCE REPORTS

Repression of TXNIP-NLRP3 axis restores intestinal barrier function via inhibition of myeloperoxidase activity and oxidative stress in nonalcoholic steatohepatitis

(2018) Ru-Xue Bai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of NLRP3 Inflammasome by Phosphorylation

(2018) Nan Song et al.   Frontiers in Immunology

Artesunate Protects LPS-Induced Acute Lung Injury by Inhibiting TLR4 Expression and Inducing Nrf2 Activation

(2017) Deli Zhao et al.   INFLAMMATION

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury

(2017) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK

(2017) Scott M. Filippone et al.   Oxidative Medicine and Cellular Longevity

Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARγ/NLRP3 inflammasome signaling pathway

(2017) Ying Xu et al.   Oncotarget

Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners

(2017) Jung Hwa Ko et al.   Oncotarget

Attenuation of gastric mucosal damage by artesunate in rat: Modulation of oxidative stress and NFκB mediated signaling

(2016) Sneh Verma et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Role of mechanistic target of rapamycin (mTOR) in renal function and ischaemia-reperfusion induced kidney injury

(2016) Reem Alshaman et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

(2016) Yanyan Cen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Liraglutide attenuates partial warm ischemia-reperfusion injury in rat livers

(2016) Ahmed A. Abdelsameea et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats

(2015) Lina Lai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells

(2015) Dunjing Wang et al.   INFLAMMATION

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Rapamycin Protection of Livers From Ischemia and Reperfusion Injury Is Dependent on Both Autophagy Induction and Mammalian Target of Rapamycin Complex 2-Akt Activation

(2015) Jianjun Zhu et al.   TRANSPLANTATION

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases

(2014) Yajie Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Liver Transplantation: An Appraisal of the Present Situation

(2013) Gerd Otto   DIGESTIVE DISEASES

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

(2013) Naoko Kamo et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Immunomodulatory and Anti-inflammatory Properties of Artesunate in Experimental Colitis

(2012) Z. Yang et al.   CURRENT MEDICINAL CHEMISTRY

Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma

(2012) Wanxing Eugene Ho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade

(2012) Archana Kumari et al.   LIFE SCIENCES

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Gene Silencing of NALP3 Protects Against Liver Ischemia–Reperfusion Injury in Mice

(2010) Ping Zhu et al.   HUMAN GENE THERAPY

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

(2010) John Evankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Artesunate for the Treatment of Severe Falciparum Malaria

(2008) Philip J. Rosenthal   NEW ENGLAND JOURNAL OF MEDICINE