Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells

A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia

(2014) Uchechukwu P. Okorji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells

(2013) L. Zhang et al.   BRITISH JOURNAL OF ANAESTHESIA

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages

(2013) Hyung Gyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

(2013) Linli Yao et al.   Journal of Neuroinflammation

Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation

(2012) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Microglia in early disease stages

(2012) Katie Kingwell   Nature Reviews Neurology

Resveratrol Inhibits Inflammatory Responses via the Mammalian Target of Rapamycin Signaling Pathway in Cultured LPS-Stimulated Microglial Cells

(2012) Lian-Mei Zhong et al.   PLoS One

Artemisinin Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Inhibiting NF-κB Pathway in Microglia Cells

(2012) Cansheng Zhu et al.   PLoS One

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells

(2011) Ik-Soo Lee et al.   NEUROSCIENCE LETTERS

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

NF-κB regulation: the nuclear response

(2009) Arun K. Mankan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lipopolysaccharide Sensitizes Neonatal Hypoxic-Ischemic Brain Injury in a MyD88-Dependent Manner

(2009) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-κB activation

(2008) Bin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY