Toll‐like receptor‐2/7‐mediated T cell activation: An innate potential to augment CD8 + T cell cytokine production

Human T cells employ conserved AU‐rich elements to fine‐tune IFN‐γ production

(2020) Julian J. Freen‐van Heeren et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function

(2020) Fiamma Salerno et al.   TRENDS IN IMMUNOLOGY

Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer

(2020) You Lu et al.   NATURE MEDICINE

mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression

(2020) Takayuki Imanishi et al.   Cell Reports

TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8 + T cells

(2020) Hu Yan et al.   IMMUNOLOGY

Blockade of T cell activation induced by the simultaneous absence of Nod1 and Nod2 is bypassed by TLR2 signals

(2020) Sashi Kasimsetty et al.   TRANSPLANT IMMUNOLOGY

Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies

(2019) Matthew R. Collinson-Pautz et al.   LEUKEMIA

Neisserial PorB Immune Enhancing Activity and Use as a Vaccine Adjuvant

(2019) Lee M. Wetzler et al.   Human Vaccines & Immunotherapeutics

Combined Adjuvant of Poly I:C Improves Antitumor Effects of CAR-T Cells

(2019) Shengmeng Di et al.   Frontiers in Oncology

Activation of the TLR signaling pathway in CD8+ T cells counteracts liver endothelial cell-induced T cell tolerance

(2019) Ejuan Zhang et al.   Cellular & Molecular Immunology

Systemic administration of imiquimod as an adjuvant improves immunogenicity of a tumor-lysate vaccine inducing the rejection of a highly aggressive T-cell lymphoma

(2019) Paula Di Sciullo et al.   CLINICAL IMMUNOLOGY

AP-1 Transcription Factors as Regulators of Immune Responses in Cancer

(2019) Vasileios Atsaves et al.   Cancers

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

(2019) John D. Gagnon et al.   Cell Reports

Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis

(2019) Qian Li et al.   Frontiers in Immunology

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

(2019) Rosa De Groot et al.   OncoImmunology

TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity

(2019) Ejuan Zhang et al.   JOURNAL OF IMMUNOLOGY

Developing neoantigen-targeted T cell–based treatments for solid tumors

(2019) Tori N. Yamamoto et al.   NATURE MEDICINE

Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells

(2018) Brian J. Morrison et al.   BMC CANCER

Measuring T Cell Responses by Flow Cytometry–Based Fluorescence In Situ Hybridization

(2018) Julian J. Freen-van Heeren et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Posttranscriptional regulation of T helper cell fate decisions

(2018) Kai P. Hoefig et al.   JOURNAL OF CELL BIOLOGY

CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape

(2018) David Pettitt et al.   MOLECULAR THERAPY

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

(2018) Fiamma Salerno et al.   NATURE IMMUNOLOGY

RNA-binding proteins control gene expression and cell fate in the immune system

(2018) Martin Turner et al.   NATURE IMMUNOLOGY

Eradication of spontaneous malignancy by local immunotherapy

(2018) Idit Sagiv-Barfi et al.   Science Translational Medicine

Flagellin is a Th1 polarizing factor for human CD4 + T cells and induces protection in a murine neonatal vaccination model of rotavirus infection

(2018) Rosario Guadalupe Labastida-Conde et al.   VACCINE

VIPER regulates naive T cell activation and effector responses: Implication in TLR4 associated acute stage T cell responses

(2018) Subhransu Sekhar Sahoo et al.   Scientific Reports

Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?

(2018) Fei Tang et al.   Cell and Bioscience

Pre-Activation of Toll-Like Receptor 2 Enhances CD8+ T-Cell Responses and Accelerates Hepatitis B Virus Clearance in the Mouse Models

(2018) Yong Lin et al.   Frontiers in Immunology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

(2018) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR Stimulation During T-cell Activation Lowers PD-1 Expression on CD8+ T Cells

(2018) Christopher D. Zahm et al.   Cancer Immunology Research

RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis

(2018) Kat S. Moore et al.   Frontiers in Physiology

Cancer Neoantigens

(2018) Ton N. Schumacher et al.   Annual Review of Immunology

Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses

(2018) Fiamma Salerno et al.   JOURNAL OF IMMUNOLOGY

Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC

(2018) Anna E. Oja et al.   Frontiers in Immunology

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

(2018) Fiamma Salerno et al.   OncoImmunology

Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option

(2018) Maartje W. Rohaan et al.   Journal for ImmunoTherapy of Cancer

Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 receptor as an immunotherapy for lymphoma

(2017) Adam Lynch et al.   IMMUNOLOGY

Naive CD4+T Cells Carrying a TLR2 Agonist Overcome TGF-β–Mediated Tumor Immune Evasion

(2017) Mohsen Ibrahim et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells

(2017) Y Lai et al.   LEUKEMIA

Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40

(2017) Aaron E. Foster et al.   MOLECULAR THERAPY

Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+T cells

(2017) Fiamma Salerno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation

(2017) Michael L. Reiser et al.   Scientific Reports

A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

(2016) Xiaojun Liu et al.   CANCER RESEARCH

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

Combined Single-Cell Measurement of Cytokine mRNA and Protein Identifies T Cells with Persistent Effector Function

(2016) Benoit P. Nicolet et al.   JOURNAL OF IMMUNOLOGY

TLR-Mediated Innate Production of IFN-γ by CD8+T Cells Is Independent of Glycolysis

(2016) Fiamma Salerno et al.   JOURNAL OF IMMUNOLOGY

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

(2016) Kira Rubtsova et al.   PLoS One

Post-transcriptional Regulation of Immunological Responses through Riboclustering

(2016) Koelina Ganguly et al.   Frontiers in Immunology

T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells

(2016) James M. Conley et al.   Frontiers in Immunology

Toxicity and management in CAR T-cell therapy

(2016) Challice L Bonifant et al.   Molecular Therapy-Oncolytics

T-cells require post-transcriptional regulation for accurate immune responses

(2015) F. Salerno et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

LPS stimulates and Hsp70 down-regulates TLR4 to orchestrate differential cytokine response of culture-differentiated innate memory CD8+ T cells

(2015) Amlan Kanti Ghosh et al.   CYTOKINE

Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells

(2015) Sanja Stevanović et al.   JOURNAL OF CLINICAL ONCOLOGY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming of Qualitatively Superior Human Effector CD8+T Cells Using TLR8 Ligand Combined with FLT3 Ligand

(2015) Anna Lissina et al.   JOURNAL OF IMMUNOLOGY

Impact of a New Fusion Receptor on PD-1–Mediated Immunosuppression in Adoptive T Cell Therapy

(2015) Sebastian Kobold et al.   JNCI-Journal of the National Cancer Institute

The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

(2015) Suzanne PM Welten et al.   eLife

Impact of a New Fusion Receptor on PD-1–Mediated Immunosuppression in Adoptive T Cell Therapy

(2015) Sebastian Kobold et al.   JNCI-Journal of the National Cancer Institute

The interface between transcriptional and epigenetic control of effector and memory CD8+T-cell differentiation

(2014) Simon M. Gray et al.   IMMUNOLOGICAL REVIEWS

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

(2014) Deborah L. Hodge et al.   JOURNAL OF AUTOIMMUNITY

MyD88 Plays a Critical T Cell-Intrinsic Role in Supporting CD8 T Cell Expansion during Acute Lymphocytic Choriomeningitis Virus Infection

(2014) A. H. Rahman et al.   JOURNAL OF IMMUNOLOGY

Activated Human Neonatal CD8+ T Cells Are Subject to Immunomodulation by Direct TLR2 or TLR5 Stimulation

(2014) M. McCarron et al.   JOURNAL OF IMMUNOLOGY

CREB, ATF, and AP-1 Transcription Factors Regulate IFN-  Secretion by Human T Cells in Response to Mycobacterial Antigen

(2014) B. Samten et al.   JOURNAL OF IMMUNOLOGY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Triggering Through Toll-like Receptor 2 Limits Chronically Stimulated T-helper Type 1 Cells From Undergoing Exhaustion

(2014) Sathi Babu Chodisetti et al.   JOURNAL OF INFECTIOUS DISEASES

The Role of Mammalian MAPK Signaling in Regulation of Cytokine mRNA Stability and Translation

(2014) Christopher Tiedje et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements

(2014) Irina Vlasova-St. Louis et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

T cell responses: naïve to memory and everything in between

(2013) Nathan D. Pennock et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Human T Cells Engineered To Express a Programmed Death 1/28 Costimulatory Retargeting Molecule Display Enhanced Antitumor Activity

(2013) C. Ankri et al.   JOURNAL OF IMMUNOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy

(2012) Z.-C. Ding et al.   BLOOD

TLR signaling in B-cell development and activation

(2012) Zhaolin Hua et al.   Cellular & Molecular Immunology

Heterotrimeric GAIT Complex Drives Transcript-Selective Translation Inhibition in Murine Macrophages

(2012) A. Arif et al.   MOLECULAR AND CELLULAR BIOLOGY

Dissecting negative regulation of Toll-like receptor signaling

(2012) Takeshi Kondo et al.   TRENDS IN IMMUNOLOGY

Regulation of TLR7/9 signaling in plasmacytoid dendritic cells

(2012) Musheng Bao et al.   Protein & Cell

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function

(2010) D. Geng et al.   BLOOD

Amplifying TLR-MyD88 Signals within Tumor-Specific T Cells Enhances Antitumor Activity to Suboptimal Levels of Weakly Immunogenic Tumor Antigens

(2010) D. Geng et al.   CANCER RESEARCH

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Increased Expression of TLR7 in CD8+ T Cells Leads to TLR7-Mediated Activation and Accessory Cell-Dependent IFN-γ Production in HIV Type 1 Infection

(2009) Yang Song et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

TLR2 engagement on memory CD8+T cells improves their cytokine-mediated proliferation and IFN-γ secretion in the absence of Ag

(2009) Anne Cottalorda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Direct recognition of LPS by human but not murine CD8+T cellsviaTLR4 complex

(2009) Mousa Komai‐Koma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The contribution of direct TLR signaling to T cell responses

(2009) Adeeb H. Rahman et al.   IMMUNOLOGIC RESEARCH

Activation requirements and responses to TLR ligands in human CD4+ T cells: Comparison of two T cell isolation techniques

(2009) Christina L. Lancioni et al.   JOURNAL OF IMMUNOLOGICAL METHODS

TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal

(2009) B. C. Mercier et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain

(2009) Eléonore Beurel et al.   Journal of Neuroinflammation

Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template

(2009) Smadar Cohen-Chalamish et al.   Nature Chemical Biology

A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection

(2008) M. Quigley et al.   BLOOD

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication

(2008) Donatella Ciuffreda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity

(2008) Nicole Asprodites et al.   FASEB JOURNAL

IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers

(2008) Bin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell expression of MyD88 is required for resistance to Toxoplasma gondii

(2008) D. F. LaRosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice

(2008) Mohamed L. Salem et al.   VACCINE