TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8 + T cells

Activation of the TLR signaling pathway in CD8+ T cells counteracts liver endothelial cell-induced T cell tolerance

(2019) Ejuan Zhang et al.   Cellular & Molecular Immunology

Liver-Mediated Adaptive Immune Tolerance

(2019) Meijuan Zheng et al.   Frontiers in Immunology

Immune Responses in the Liver

(2018) Paul Kubes et al.   Annual Review of Immunology

Circulating microbiome in blood of different circulatory compartments

(2018) Robert Schierwagen et al.   GUT

TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production

(2018) Jia Liu et al.   JOURNAL OF IMMUNOLOGY

Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP–NLRC4 inflammasome

(2018) Jingyi Yang et al.   Cell Discovery

FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury

(2018) Chang Yeob Han et al.   Cell Reports

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

(2018) Adam J. Gehring et al.   GASTROENTEROLOGY

Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response

(2017) Yuan Cao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+T-cell axis

(2016) Craig M. Brackett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin

(2015) Wei Li et al.   Cellular & Molecular Immunology

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing

(2015) Ilseyar Akhmetzyanova et al.   PLoS Pathogens

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

(2014) Yang Xiao et al.   Cellular & Molecular Immunology

Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses

(2014) Zhiyong Ma et al.   Cellular & Molecular Immunology

Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection

(2014) Percy A. Knolle et al.   GASTROENTEROLOGY

Immune tolerance in liver disease

(2014) Ian N. Crispe   HEPATOLOGY

Flagellins of Salmonella Typhi and Nonpathogenic Escherichia coli Are Differentially Recognized through the NLRC4 Pathway in Macrophages

(2014) Jingyi Yang et al.   Journal of Innate Immunity

Long-term stimulation of Toll-like receptor 3 in primary human hepatocytes leads to sensitization for antiviral responses induced by poly I:C treatment

(2014) R. Broering et al.   JOURNAL OF VIRAL HEPATITIS

Microbiota-liver axis in hepatic disease

(2013) Benoit Chassaing et al.   HEPATOLOGY

TLR1/2 Ligand-Stimulated Mouse Liver Endothelial Cells Secrete IL-12 and Trigger CD8+ T Cell Immunity In Vitro

(2013) J. Liu et al.   JOURNAL OF IMMUNOLOGY

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

(2013) Li-Rung Huang et al.   NATURE IMMUNOLOGY

Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist

(2013) L. G. Burdelya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver-Primed Memory T Cells Generated under Noninflammatory Conditions Provide Anti-infectious Immunity

(2013) Jan P. Böttcher et al.   Cell Reports

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation

(2012) Keita Un et al.   HEPATOLOGY

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

(2012) Sorina Georgiana Boaru et al.   Journal of Inflammation-London

Amino Acid Substitutions at Positions 122 and 145 of Hepatitis B Virus Surface Antigen (HBsAg) Determine the Antigenicity and Immunogenicity of HBsAg and InfluenceIn VivoHBsAg Clearance

(2012) Chunchen Wu et al.   JOURNAL OF VIROLOGY

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Dynamic Changes of Lipopolysaccharide Levels in Different Phases of Acute on Chronic Hepatitis B Liver Failure

(2012) Calvin Pan et al.   PLoS One

Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1

(2011) Xiaoyong Zhang et al.   HEPATOLOGY

Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury

(2011) Karim C. El Kasmi et al.   HEPATOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Hepatocyte entry leads to degradation of autoreactive CD8 T cells

(2011) V. Benseler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Pathway for Inducible Nitric-oxide Synthase Activation through Inflammasomes

(2010) Carina L. Buzzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication

(2009) C. Wu et al.   JOURNAL OF GENERAL VIROLOGY

B7-H1 on Hepatocytes Facilitates Priming of Specific CD8 T Cells But Limits the Specific Recall of Primed Responses

(2008) Christian Wahl et al.   GASTROENTEROLOGY